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Association Between Arterial Stiffness, Frailty and Fall-Related Injuries in Older Adults

Authors Turusheva A, Frolova E, Kotovskaya Y, Petrosyan Y, Dumbadze R

Received 29 February 2020

Accepted for publication 30 June 2020

Published 20 July 2020 Volume 2020:16 Pages 307—316


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Harry Struijker-Boudier

Video abstract presented by Anna Turusheva.

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Anna Turusheva,1 Elena Frolova,1 Yulia Kotovskaya,2 Yurij Petrosyan,1 Rauli Dumbadze1

1The North-Western State Medical University Named After I.I. Mechnikov, St. Petersburg, Russia; 2Russian Clinical and Research Center of Gerontology, Pirogov Russian National Research Medical University, Moscow, Russia

Correspondence: Anna Turusheva
The North-Western State Medical University Named After I.I. Mechnikov, St. Petersburg, Russia
Tel +7-951-676-37-14
Fax +7 (812) 598-93-20

Purpose: This study was conducted to investigate the relationships between arterial stiffness, frailty and fall-related injuries among community-dwelling older adults.
Materials and Methods: A cross-sectional study of a random sample of older adults aged 60 years and older was conducted. Main study parameters: arterial stiffness was measured by the determining the cardio-ankle vascular index (CAVI); Frailty status was defined using a 7-item frailty screening scale, developed in Russia. This questionnaire included question about falls and fall-related injuries. Orthostatic test and anthropometric tests were done. Medical history (comorbidity, medications), the Osteoporosis Self-assessment Tool (OST), nutritional, physical, cognitive and functional status were evaluated.
Results: The study population included 163 people aged 60– 89 years. The average predicted value of CAVI in women aged 60– 69 was 9.13 ± 0.13, in men, 9.49 ± 0.05; in women aged 70– 79, it was 9.49 ± 0.16, in men, 9.73 ± 0.11; in women aged 80 and older it was 10.04 ± 0.18, in men, 10.24 ± 0.10 units. The CAVI above the predicted value was associated with fall-related injuries even after adjustment for age, sex, use of β-blockers (BBs), history of stroke, and region of residence with the odds ratio 3.52 (95% CI: 1.03 − 12.04).
Conclusion: Our study revealed an independent association between arterial stiffness and fall-related injuries in older adults over 60 years. The findings suggest that clinicians, especially geriatricians, should pay attention to arterial stiffness of patients with fall-related injuries. Similarly, the patients with CAVI above age-predicted value should be evaluated for risk of falls for prevention of fall-related injuries.

Keywords: cardio-ankle vascular index (CAVI), falls, elderly, falls prevention, β-blockers (BBs), stroke

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