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Aspirin “Allergy”-Induced Thrombocytopenia: A Case Report

Authors Fu W, Xu S, Dong X, Xie Q, Gao Y

Received 21 December 2020

Accepted for publication 25 February 2021

Published 9 March 2021 Volume 2021:14 Pages 201—205

DOI https://doi.org/10.2147/JAA.S292567

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Luis Garcia-Marcos


Wei Fu, Shanshan Xu, Xiang Dong, Qing Xie, Yadong Gao

Department of Allergology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China

Correspondence: Yadong Gao; Wei Fu
Department of Allergology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, People’s Republic of China
Tel +86 15071384536
Email [email protected]; [email protected]

Abstract: Aspirin is clinically widely used to inhibit platelet aggregation after coronary intervention. Herein we describe a case of aspirin-induced thrombocytopenia that may be related to allergy to aspirin. A 47‐year‐old man developed a delayed hypersensitivity reaction to aspirin, with pruritus, purpura and thrombocytopenia, increased peripheral blood eosinophils and enlarged inguinal lymph node. All the symptoms disappeared in 2 years after stopping aspirin. Aspirin-induced thrombocytopenia related to allergy is rarely reported. Aspirin hypersensitivity should be taken into consideration in case of unexplained thrombocytopenia in patients taking aspirin. Aspirin “allergy”-induced thrombocytopenia may involve both aspirin related IgG and IgE antibodies.

Keywords: aspirin, allergy, thrombocytopenia, platelets

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