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Application of supercritical antisolvent method in drug encapsulation: a review

Authors Kalani M, Yunus

Published 6 July 2011 Volume 2011:6 Pages 1429—1442

DOI https://doi.org/10.2147/IJN.S19021

Review by Single-blind

Peer reviewer comments 4


Mahshid Kalani, Robiah Yunus
Chemical and Environmental Engineering, Faculty of Engineering, University Putra Malaysia, Selangor Darul Ehsan, Malaysia

Abstract: The review focuses on the application of supercritical fluids as antisolvents in the pharmaceutical field and demonstrates the supercritical antisolvent method in the use of drug encapsulation. The main factors for choosing the solvent and biodegradable polymer to produce fine particles to ensure effective drug delivery are emphasized and the effect of polymer structure on drug encapsulation is illustrated. The review also demonstrates the drug release mechanism and polymeric controlled release system, and discusses the effects of the various conditions in the process, such as pressure, temperature, concentration, chemical compositions (organic solvents, drug, and biodegradable polymer), nozzle geometry, CO2 flow rate, and the liquid phase flow rate on particle size and its distribution.

Keywords: supercritical antisolvent method, drug encapsulation, particle size, drug release mechanisms, drug delivery

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