Antipollution skin protection – a new paradigm and its demonstration on two active compounds
Authors Portugal-Cohen M, Oron M, Cohen D, Ma'or Z
Received 4 December 2016
Accepted for publication 21 March 2017
Published 17 May 2017 Volume 2017:10 Pages 185—193
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Jeffrey Weinberg
Meital Portugal-Cohen,1,2 Miriam Oron,1,2 Dror Cohen,1–3 Zeevi Ma’or1,2
1AHAVA Dead Sea Laboratories, Lod, Israel; 2The Dead Sea Laboratory for Skin Biochemistry and Biotechnology, Dead Sea and Arava Science Center, Masada, Israel; 3The Institute for Drug Research, The Hebrew University of Jerusalem, Jerusalem, Israel
Background: Urban pollution is a major source of concern for human health and is a complex of many environmental factors. The topical exposure to pollution activates cutaneous stress.
Objective: In this study, we tested the antipollution protection of two active components: Dead Sea minerals (Dead Sea mineral-rich water [DSW]) and anionic polysaccharide (PolluStop® [PS]).
Materials and methods: Two representative pollution models were studied using reconstructed epidermis: 1) mixture of pollutants (MOP) containing heavy metals and atmospheric particulate matter and 2) ozone exposure. DSW and PS were topically applied alone or in combination, and their protection against pollution was assessed by testing the levels of the inflammation markers interleukin 1α (IL-1α) and prostaglandin E2 (PGE2).
Results: MOP exposure induced IL-1α release, which was attenuated following pre-application with DSW and PS alone or in combination. Ozone exposure induced IL-1α and PGE2 release. Pre-application with DSW or PS alone did not inhibit IL-1α and PGE2 overproduction. Only when DSW and PS were mixed together, inhibition of these inflammatory markers was observed.
Conclusion: The observations reveal the potential use of active agents in combination for a selective mode of protection from urban pollution. This is because many active materials cannot solely provide a broad protection against different types of pollutants. This strategy might be beneficial for future antipollution regimen formulated in both pharmaceutical and cosmetic products.
Keywords: urban pollution, dermal exposure, inflammation, oxidation, alternative skin models, antipollution activity
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.Download Article [PDF] View Full Text [HTML][Machine readable]