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Acute and subchronic toxicity analysis of surface modified paclitaxel attached hydroxyapatite and titanium dioxide nanoparticles

Authors Venkatasubbu G, Ramasamy S, Gaddam PR, Kumar J

Received 8 January 2015

Accepted for publication 5 March 2015

Published 1 October 2015 Volume 2015:10(Supplement 1 Challenges in biomaterials research) Pages 137—148

DOI https://doi.org/10.2147/IJN.S79991

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Thomas J Webster


Gopinath Devanand Venkatasubbu,1 S Ramasamy,2 Pramod Reddy Gaddam,3 J Kumar2

1Department of Biotechnology, University of Madras, Chennai, Tamil Nadu, India; 2Crystal Growth Centre, Anna University, Chennai, Tamil Nadu, India; 3Department of Pharmacology, Siddha Central Research Institute, Chennai, Tamil Nadu, India

Abstract: Nanoparticles are widely used for targeted drug delivery applications. Surface modification with appropriate polymer and ligands is carried out to target the drug to the affected area. Toxicity analysis is carried out to evaluate the safety of the surface modified nanoparticles. In this study, paclitaxel attached, folic acid functionalized, polyethylene glycol modified hydroxyapatite and titanium dioxide nanoparticles were used for targeted drug delivery system. The toxicological behavior of the system was studied in vivo in rats and mice. Acute and subchronic studies were carried out. Biochemical, hematological, and histopathological analysis was also done. There were no significant alterations in the biochemical parameters at a low dosage. There was a small change in alkaline phosphatase (ALP) level at a high dosage. The results indicate a safe toxicological profile.

Keywords: acute and subchronic toxicology, hematological analysis, biochemical analysis, histopathology

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