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Accelerated corneal collagen cross-linking should be modified

Authors Kymionis G, Tsoulnaras K

Received 20 August 2014

Accepted for publication 21 August 2014

Published 21 November 2014 Volume 2014:8 Pages 2333—2335

DOI https://doi.org/10.2147/OPTH.S72995

Checked for plagiarism Yes

Editor who approved publication: Dr Scott Fraser


George D Kymionis,1,2 Konstantinos I Tsoulnaras1

1Vardinoyiannion Eye Institute of Crete, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece; 2Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, FL, USA

We have read with interest the recently published comparative study regarding the accelerated versus conventional corneal collagen cross-linking (CXL) in the treatment of mild keratoconus. We would like to underline the importance of the CXL treatment time reduction in this time consuming operation.1 Accelerated CXL became popular due to patient and doctor comfort in comparison to the previously widespread use of Dresden protocol which is successful in terms of safety and efficacy. Based on the Bunsen-Roscoe law of reciprocity many modifications to the time and irradiation settings have been proposed while the total energy dose delivered to the cornea should be maintained at 5.4 J/cm2.2

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