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8 hrs Safety Evaluation Of A Multi-Pressure Dial In Eyes With Glaucoma: Prospective, Open-Label, Randomized Study

Authors Samuelson TW, Ferguson TJ, Radcliffe NM, Lewis R, Schweitzer J, Swan R, Berdahl JP

Received 30 May 2019

Accepted for publication 13 September 2019

Published 2 October 2019 Volume 2019:13 Pages 1947—1953

DOI https://doi.org/10.2147/OPTH.S217736

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Melinda Thomas

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser


Thomas W Samuelson,1 Tanner J Ferguson,2 Nathan M Radcliffe,3 Richard Lewis,4 Justin Schweitzer,5 Russell Swan,5 John P Berdahl5

1Minnesota Eye Consultants, Minneapolis, MN, USA; 2Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA; 3Department of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, NY, USA; 4Sacramento Eye Consultants, Sacramento, CA, USA; 5Vance Thompson Vision, Sioux Falls, SD, USA

Correspondence: Tanner J Ferguson
Cole Eye Institute, Cleveland Clinic, Cleveland OH, USA
Email tannerferg@gmail.com

Purpose: To investigate the safety and tolerability of the multi-pressure dial with a continuous 8-hr duration in subjects with open-angle glaucoma.
Design: Prospective, controlled open-label, randomized, single site study.
Subjects: Twenty eyes of 10 subjects with open-angle glaucoma were fitted with a multi-pressure dial and randomized to negative pressure application of −10 mmHg in one eye for 8 (continuous) hours and ambient atmospheric pressure in the contralateral eye.
Methods: Main safety outcome measures include best-corrected visual acuity (BCVA), intraocular pressure (IOP) changes from baseline after negative pressure application, slit lamp and dilated fundus exam findings, and rate of adverse events. Subjective assessments were administered both hourly during the 8-hr study period and immediately following the study period.
Results: There were no statistically significant changes in IOP, BCVA or TBUT immediately following the 8-hr study period or at the 1-week follow-up visit. Patient-reported tolerability was favorable with a mean response of 1.8 ± 0.4 (scale → 1=best, 10 = worst). Subjects also reported positive interest in the MPD as a glaucoma therapy with a mean response of 1.8 ± 0.5 (scale → 1=best, 10 = worst). One adverse event was reported (headache) and resolved at conclusion of the Day 0 visit.
Conclusion: The MPD demonstrated favorable safety with key parameters remaining stable after an 8-hr wear with negative pressure. Negative pressure application through the MPD was well tolerated by subjects enrolled in the study. The favorable findings demonstrate the safety of sustained delivery of negative pressure over a continuous, uninterrupted 8-hr duration.

Keywords: multi-pressure dial, normal-tension glaucoma, open-angle glaucoma, glaucoma treatment


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