Back to Browse Journals » International Journal of Nanomedicine » Volume 8 » Issue 1

Zirconium, calcium, and strontium contents in magnesium based biodegradable alloys modulate the efficiency of implant-induced osseointegration

Authors Mushahary D, Sravanthi R, Li Y, Kumar MJ, Harishankar N, Hodgson PD, Wen C, Pande G

Published Date August 2013 Volume 2013:8(1) Pages 2887—2902

DOI http://dx.doi.org/10.2147/IJN.S47378

Received 29 April 2013, Accepted 14 June 2013, Published 9 August 2013

Dolly Mushahary,1,2 Ragamouni Sravanthi,2 Yuncang Li,2 Mahesh J Kumar,1 Nemani Harishankar,4 Peter D Hodgson,1 Cuie Wen,3 Gopal Pande2

1Institute for Frontier Materials, Deakin University, Geelong, Australia; 2CSIR- Centre for Cellular and Molecular Biology, Hyderabad, India; 3Faculty of Engineering and Industrial Sciences, Swinburne University of Technology, Hawthorn, Australia; 4National Institute of Nutrition (ICMR), Tarnaka, Hyderabad, India

Abstract: Development of new biodegradable implants and devices is necessary to meet the increasing needs of regenerative orthopedic procedures. An important consideration while formulating new implant materials is that they should physicochemically and biologically mimic bone-like properties. In earlier studies, we have developed and characterized magnesium based biodegradable alloys, in particular magnesium-zirconium (Mg-Zr) alloys. Here we have reported the biological properties of four Mg-Zr alloys containing different quantities of strontium or calcium. The alloys were implanted in small cavities made in femur bones of New Zealand White rabbits, and the quantitative and qualitative assessments of newly induced bone tissue were carried out. A total of 30 experimental animals, three for each implant type, were studied, and bone induction was assessed by histological, immunohistochemical and radiological methods; cavities in the femurs with no implants and observed for the same period of time were kept as controls. Our results showed that Mg-Zr alloys containing appropriate quantities of strontium were more efficient in inducing good quality mineralized bone than other alloys. Our results have been discussed in the context of physicochemical and biological properties of the alloys, and they could be very useful in determining the nature of future generations of biodegradable orthopedic implants.

Keywords: osteoblasts, bone mineralization, corrosion, osseointegration, surface energy, peri-implant

Download Article [PDF] View Full Text [HTML] 

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php

Readers of this article also read:

Lumbosacral plexus delineation, dose distribution, and its correlation with radiation-induced lumbosacral plexopathy in cervical cancer patients

Tunio M, Al Asiri M, Bayoumi Y, Abdullah O Balbaid A, AlHameed M, Gabriela SL, Amir O Ali A

OncoTargets and Therapy 2015, 8:21-27

Published Date: 23 December 2014

Mussel-inspired human gelatin nanocoating for creating biologically adhesive surfaces

Yang X, Zhu L, Tada S, Zhou D, Kitajima T, Isoshima T, Yoshida Y, Nakamura M, Yan W, Ito Y

International Journal of Nanomedicine 2014, 9:2753-2765

Published Date: 29 May 2014

Gold nanoparticles as physiological markers of urine internalization into urothelial cells in vivo

Hudoklin S, Zupančič D, Makovec D, Kreft ME, Romih R

International Journal of Nanomedicine 2013, 8:3945-3953

Published Date: 14 October 2013

Physicochemical characterization of a novel graphene-based magnetic resonance imaging contrast agent

Kanakia S, Toussaint JD, Mullick Chowdhury S, Lalwani G, Tembulkar T, Button T, Shroyer KR, Moore W, Sitharaman B

International Journal of Nanomedicine 2013, 8:2821-2833

Published Date: 5 August 2013

A new approach to the treatment of recurrent aphthous stomatitis with bioadhesive gels containing cyclosporine A solid lipid nanoparticles: in vivo/in vitro examinations

Karavana SY, Gökçe EH, Rençber S, Özbal S, Pekçetin Ç, Güneri P, Ertan G

International Journal of Nanomedicine 2012, 7:5693-5704

Published Date: 9 November 2012

Corrigendum

Wu Q, Chu M

International Journal of Nanomedicine 2012, 7:4531-4532

Published Date: 15 August 2012

Fabrication and characterization of a rapid prototyped tissue engineering scaffold with embedded multicomponent matrix for controlled drug release

Chen M, Le DQ, Hein S, Li P, Nygaard JV, Kassem M, Kjems J, Besenbacher F, Bünger C

International Journal of Nanomedicine 2012, 7:4285-4297

Published Date: 3 August 2012

The scent fingerprint of hepatocarcinoma: in-vitro metastasis prediction with volatile organic compounds (VOCs)

Amal H, Ding L, Liu BB, Tisch U, Xu ZQ, Shi DY, Zhao Y, Chen J, Sun RX, Liu H, Ye SL, Tang ZY, Haick H

International Journal of Nanomedicine 2012, 7:4135-4146

Published Date: 30 July 2012