Journal of Blood Medicine
Open access peer-reviewed scientific and medical journals.
Dove Medical Press is now a member of the Open Access Initiative
An Author's Guide
A guide to help authors get their paper published.
Support Open Access and Dove Press
Promotional Article Monitoring - further details
Favored Author Program
Real benefits for authors, including fast-track processing of papers.
The role of ofatumumab in the treatment of chronic lymphocytic leukemia resistant to previous therapies
(5271) Total Article Views
Authors: Jorge Castillo, Kimberly Perez
Published Date February 2010
Volume 2010:1 Pages 1 - 8
Jorge Castillo, Kimberly Perez
The Warren Alpert Medical School of Brown University, Division of Hematology and Oncology, The Miriam Hospital, Providence, RI , USA
Abstract: Chronic lymphocytic leukemia (CLL) is an indolent but incurable disease. Despite the improvement of the available therapies, the management of heavily-treated CLL patients represents a challenge for modern practitioners. Ofatumumab is a second-generation, fully human anti-CD20 monoclonal antibody that has shown activity in CLL patients who have failed very effective therapies such as fludarabine, alemtuzumab and rituximab. Potential benefits of ofatumumab include powerful complement-dependent cytotoxicity, less immunogenicity, faster infusions and activity in resistant CLL patients. Recently, the FDA has approved ofatumumab for the treatment of CLL patients who have failed fludarabine and alemtuzumab-based regimens. The aim of this review is to summarize the current knowledge regarding pharmacology, mechanism of action, pre-clinical and clinical development, and the role of ofatumumab for the treatment of CLL patients who have failed previous therapies. Further research is necessary to further define the role of ofatumumab in the treatment of CLL.
Keywords: ofatumumab, CLL, chronic lymphocytic leukemia, monoclonal antibodies, CD20
Cannotea Citeulike Del.icio.us Facebook LinkedIn Twitter
Readers of this article also read:
Call For Submissions
Submit Original Research Article, Review, Case Report, or Rapid Communication in Journal of Blood Medicine
- Treatment of hemophilia: a review of current advances and ongoing issues
- Use of sulodexide in patients with peripheral vascular disease
- Deep vein thrombosis: a clinical review
- Treatment of anemia in chronic kidney disease: known, unknown, and both