Back to Browse Journals » International Journal of Nanomedicine » Volume 4

Smart RISUG: A potential new contraceptive and its magnetic field-mediated sperm interaction

Authors Rakhi K Jha, Pradeep K Jha, Sujoy K Guha

Published Date March 2009 Volume 2009:4 Pages 55—64

DOI http://dx.doi.org/10.2147/IJN.S4818

Published 17 March 2009

Rakhi K Jha1,2, Pradeep K Jha1,3, Sujoy K Guha1

1School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, West Bengal, India; 2Toxicology Laboratory, Department of Zoology, ChCS University, Meerut, UP, India; 3Department of Management studies, VIET, UP Tech. Univ., Lucknow, UP, India

Abstract: The rationale and technique underlying a novel concept of noninvasive fertility control by a new Cuproferrogel contraceptive drug, iron oxide–copper–styrene maleic anhydride–dimethyl sulphoxide (Fe3O4–Cu–SMA–DMSO) composite named ‘Smart RISUG’ (smart reversible inhibition of sperm under guidance) in presence of pulsed magnetic field (PMF; 1 mT to 800 mT) is explained. It was synthesized by dispersing iron oxide particles and copper particles into SMA-DMSO (male contraceptive RISUG) and characterized for particle distribution, particle size measurement and transmittance peaks, etc. Interaction of the RISUG particles as well as Smart RISUG particles with Albino rat sperm cell was studied in presence as well as absence of PMF. To find an explanation to increased reaching of the Smart RISUG drug into sperm under influence of magnetic field, the transport properties were characterized by high resolution transmission electron microscopy and atomic force microscopy. Smart RISUG could be mobilized into sperm cell membrane at the PMF, 760 mT in about 50 seconds. Adoption of novel drug Smart RISUG involving new technique may open the pathway for non surgical control of drug distribution, detection and restoration of the normal fertility after removal of the contraceptive from the male/female reproductive tube in presence of electromagnetic field.

Keywords: smart RISUG, pulsed magnetic field, noninvasive fertility control, drug distribution, sperm cell

Download Article [PDF] 

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php

Readers of this article also read:

Silver nanoparticle/chitosan oligosaccharide/poly(vinyl alcohol) nanofibers as wound dressings: a preclinical study

Li CW, Fu RQ, Yu CP, Li ZH, Guan HY, Hu DQ, Zhao DH, Lu LC

International Journal of Nanomedicine 2013, 8:4131-4145

Published Date: 1 November 2013

Preparation, characterization, and in vivo pharmacokinetics of nanostructured lipid carriers loaded with oleanolic acid and gentiopicrin

Zhang KC, Lv SW, Li XY, Feng YF, Li X, Liu L, Li S, Li YJ

International Journal of Nanomedicine 2013, 8:3227-3239

Published Date: 22 August 2013

Using poly(lactic-co-glycolic acid) microspheres to encapsulate plasmid of bone morphogenetic protein 2/polyethylenimine nanoparticles to promote bone formation in vitro and in vivo

Qiao C, Zhang K, Jin H, Miao L, Shi C, Liu X, Yuan A, Liu J, Li D, Zheng C, Zhang G, Li X, Yang B, Sun H

International Journal of Nanomedicine 2013, 8:2985-2995

Published Date: 13 August 2013

Simple room-temperature preparation of high-yield large-area graphene oxide

Huang NM, Lim HN, Chia CH, Yarmo MA, Muhamad MR

International Journal of Nanomedicine 2011, 6:3443-3448

Published Date: 19 December 2011

Rehydrated sterically stabilized phospholipid nanomicelles of budesonide for nebulization: physicochemical characterization and in vitro, in vivo evaluations

Sahib MN, Darwis Y, Peh KK, Abdulameer SA, Tan YTF

International Journal of Nanomedicine 2011, 6:2351-2366

Published Date: 14 October 2011

Renal artery stenosis in kidney transplants: assessment of the risk factors

Etemadi J, Rahbar K, Haghighi AN, Bagheri N, Falaknazi K, Ardalan MR, Ghabili K, Shoja MM

Vascular Health and Risk Management 2011, 7:503-507

Published Date: 10 August 2011

Multiple treatment comparison meta-analyses: a step forward into complexity

Mills E, Bansback N, Ghement I, Thorlund K, Kelly S, Puhan M, Wright J

Clinical Epidemiology 2011, 3:193-202

Published Date: 27 May 2011

Intracellular heavy metal nanoparticle storage: progressive accumulation within lymph nodes with transformation from chronic inflammation to malignancy

Tommaso Iannitti, Stefania Capone, Antonietta Gatti, et al

International Journal of Nanomedicine 2010, 5:955-960

Published Date: 15 November 2010