Six-month depot formulation of leuprorelin acetate in the treatment of prostate cancer

Review

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Authors: Rajni Sethi, Nicholas Sanfilippo

Published Date June 2009 Volume 2009:4 Pages 259 - 267

DOI: http://dx.doi.org/10.2147/CIA.S4885

Rajni Sethi, Nicholas Sanfilippo

Department of Radiation Oncology, New York University Langone Medical Center, New York, NY, USA

Abstract: Hormonal deprivation therapy is well established for the treatment of locally advanced and metastatic prostate cancer, as well as the adjuvant treatment of some patients with localized disease. Long-acting gonadotropin releasing hormone (GnRH) agonists have become a mainstay of androgen deprivation therapy, due to their efficacy, tolerability, and convenience of use. One-month, 3-month, and 4-month depot leuprorelin formulations are well established and widely used to this end. Recently, a 6-month depot leuprorelin has been approved for use in advanced and metastatic prostate cancer patients. With similar efficacy and side effect profiles to earlier formulations, 6-month depot leuprorelin is a convenient treatment option for these patients. This review will highlight the role of GnRH agonists in the treatment of prostate cancer with a focus on the clinical efficacy, pharmacology, and patient-focused outcomes of the newer 6-month 45 mg depot leuprorelin formulation in comparison to available shorter-acting products.

Keywords: prostate cancer, leuprorelin, hormonal deprivation therapy