International Journal of Chronic Obstructive Pulmonary Disease
Open access peer-reviewed scientific and medical journals.
Dove Medical Press is now a member of the Open Access Initiative
An Author's Guide
A guide to help authors get their paper published.
Support Open Access and Dove Press
Promotional Article Monitoring - further details
Favored Author Program
Real benefits for authors, including fast-track processing of papers.
Lower limb vasodilatory capacity is not reduced in patients with moderate COPD
(4713) Total Article Views
Authors: Surendran Sabapathy, Marc F Awater, Donald A Schneider, Rebecca A Kingsley, Maria TE Hopman, Norman R Morris
Published Date May 2006
Volume 2006:1(1) Pages 73 - 81
Surendran Sabapathy1, Marc F Awater2, Donald A Schneider1, Rebecca A Kingsley1, Maria TE Hopman2, Norman R Morris1
1School of Physiotherapy and Exercise Science, and Heart Foundation Research Centre, Gold Coast campus, Griffith University, QLD, Australia; 2Department of Physiology, University of Nijmegen, Nijmegen, The Netherlands
Abstract: We compared exercise capacity (peak O2 uptake; VO2peak) and lower limb vasodilatory capacity in 9 patients with moderate COPD (FEV1 52.7 ± 7.6% predicted) and 9 age-matched healthy control subjects. VO2peak was measured via open circuit spirometry during incremental cycling. Calf blood flow (CBF) measurements were obtained at rest and after 5 minutes of ischemia using venous occlusion plethysmography. While VO2peak was significantly lower in the COPD patients (15.8 ± 3.5 mL·kg–1·min–1) compared with the control group (25.2 ± 3.5 mL·kg–1·min–1), there were no significant differences between groups in peak CBF or peak calf conductance measured 7 seconds post-ischemia. VO2peak was significantly correlated with peak CBF and peak conductance in the control group, whereas no significant relationship was found between these variables in the COPD group. However, the rate of decay in blood flow following ischemia was significantly slower (p < 0.05) for the COPD group (–0.036 ± 0.005 mL·100 mL–1·min–1·s–1) when compared with controls (–0.048 ± 0.015 mL·100mL–1·min–1·s–1). The results suggest that the lower peak exercise capacity in patients with moderate COPD is not related to a loss in leg vasodilatory capacity.
Keywords: obstructive lung disease, exercise capacity, reactive hyperemia, calf blood flow
Cannotea Citeulike Del.icio.us Facebook LinkedIn Twitter
Readers of this article also read:
- Journal Indexing
See where all the Dove Press journals are indexed.
"I was impressed at the rapidity of publication from submission to final acceptance." Dr Edwin Thrower, PhD, Yale University.
- MLA'14 -
May 16–21, 2014
- ERS Int'l Congress
6 - 10 September, 2014
- CHEST 2014
25 - 30 October, 2014
- Clinical effectiveness of the Respimat® inhaler device in managing chronic obstructive pulmonary disease: evidence when compared with other handheld inhaler devices
- Chronic obstructive pulmonary disease as an independent risk factor for cardiovascular morbidity
- The pathophysiology of bronchiectasis
- Exacerbation rate, health status and mortality in COPD – a review of potential interventions