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Drug Design, Development and Therapy
ISSN: 1177-8881
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Archive: Volume 16, 2022
Clinical Insight on Semaglutide for Chronic Weight Management in Adults: Patient Selection and Special Considerations
Chao AM, Tronieri JS, Amaro A, Wadden TA
Drug Design, Development and Therapy 2022, 16:4449-4461
Published Date: 29 December 2022
Pharmacokinetics of a Fixed-Dose Combination of Teneligliptin Hydrochloride Hydrate and Modified-Release Metformin Under Fasting and Fed Conditions in Healthy Subjects
Goak IS, Lee JA, Jeong MH, Moon SJ, Kim MG
Drug Design, Development and Therapy 2022, 16:4439-4448
Published Date: 28 December 2022
Risk Factors for Hepatic Encephalopathy in Hepatocellular Carcinoma After Sorafenib or Lenvatinib Treatment: A Real-World Study
Chen B, Zhang L, Cheng J, Wu T, Lei J, Yang X, Zhang R, Safadi R, Li Y, Si T, Lu Y
Drug Design, Development and Therapy 2022, 16:4429-4437
Published Date: 28 December 2022
Ketamine Attenuates Airway Inflammation via Inducing Inflammatory Cells Apoptosis and Activating Nrf2 Pathway in a Mixed-Granulocytic Murine Asthma Model
Xiao S, Zhou Y, Wang Q, Yang D
Drug Design, Development and Therapy 2022, 16:4411-4428
Published Date: 28 December 2022
Notoginsenoside R1 Promotes Proliferation and Osteogenic Differentiation of hPDLSCs via Wnt/β-Catenin Signaling Pathway
Han R, Zhang W, Zhang L, Zou J, Yang Y, Li H, Zhang J
Drug Design, Development and Therapy 2022, 16:4399-4409
Published Date: 23 December 2022
Chemical Chaperones to Inhibit Endoplasmic Reticulum Stress: Implications in Diseases
Jeon JH, Im S, Kim HS, Lee D, Jeong K, Ku JM, Nam TG
Drug Design, Development and Therapy 2022, 16:4385-4397
Published Date: 23 December 2022
Anti-Inflammatory Activation of Phellodendri Chinensis Cortex is Mediated by Berberine Erythrocytes Self-Assembly Targeted Delivery System
Li M, Qin Z, Yu Q, Huang Z, Cheng J, Zhong L, Liu Y, Xie J, Li Y, Chen J, Zhan R, Su Z
Drug Design, Development and Therapy 2022, 16:4365-4383
Published Date: 23 December 2022
Metabolomics Study of Shaoyao Plants Decoction on the Proximal and Distal Colon in Mice with Dextran Sulfate Sodium-Induced Colitis by UPLC-Q-TOF-MS
Luo Y, Wu J, Liu Y, Shen Y, Zhu F, Wu J, Hu Y
Drug Design, Development and Therapy 2022, 16:4343-4364
Published Date: 22 December 2022
Network Pharmacology Integrated with Transcriptomics Analysis Reveals Ermiao Wan Alleviates Atopic Dermatitis via Suppressing MAPK and Activating the EGFR/AKT Signaling
Xia T, Liang X, Liu CS, Hu YN, Luo ZY, Tan XM
Drug Design, Development and Therapy 2022, 16:4325-4341
Published Date: 21 December 2022
Antiviral Activity of Oridonin Against Herpes Simplex Virus Type 1
Jiang K, Feng J, Qi X, Ran L, Xie L
Drug Design, Development and Therapy 2022, 16:4311-4323
Published Date: 20 December 2022
Effect of Rifampicin on the Pharmacokinetics of Evogliptin in Healthy Volunteers
Shin Y, Choi C, Oh ES, Kim CO, Park K, Park MS
Drug Design, Development and Therapy 2022, 16:4301-4310
Published Date: 20 December 2022
Effects of the Different Doses of Esketamine on Postoperative Quality of Recovery in Patients Undergoing Modified Radical Mastectomy: A Randomized, Double-Blind, Controlled Trial
Zhu M, Xu S, Ju X, Wang S, Yu X
Drug Design, Development and Therapy 2022, 16:4291-4299
Published Date: 16 December 2022
Design and Optimization of Rivaroxaban-Cyclodextrin-Polymer Triple Complex Formulation with Improved Solubility
Kang JH, Lee JE, Jeong SJ, Park CW, Kim DW, Weon KY
Drug Design, Development and Therapy 2022, 16:4279-4289
Published Date: 16 December 2022
Efficacy and Safety of the PD-1 Inhibitor Combined with Albumin-Bound Paclitaxel and Nedaplatin in Preoperative Neoadjuvant Therapy of Unresectable Stage III Lung Squamous Cell Carcinoma
Xu H, Wang W, Yin J, Song C, Li L, Sun Z
Drug Design, Development and Therapy 2022, 16:4269-4277
Published Date: 14 December 2022
Efficiency and Safety of Baofei Granules in Chronic Obstructive Pulmonary Disease (Lung and Spleen Qi Deficiency Syndrome): A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase II Clinical Trial
Sun Y, Chen X, Zhang L, Yuan WA, Chen Q, Zhang YB, Liu LJ, Zhang W, Sun M
Drug Design, Development and Therapy 2022, 16:4251-4267
Published Date: 14 December 2022
Development, in vitro Evaluation, and in vivo Study of Adhesive Buccal Films for the Treatment of Diabetic Pediatrics via Trans Mucosal Delivery of Gliclazide
Gaber DA, Alburaykan AI, Alruthea LM, Aldohan NS, Alharbi RF, Aljohani AR, Albilaihi HM, Adogim SS
Drug Design, Development and Therapy 2022, 16:4235-4250
Published Date: 13 December 2022
Keloid Patient Plasma-Derived Exosomal hsa_circ_0020792 Promotes Normal Skin Fibroblasts Proliferation, Migration, and Fibrogenesis via Modulating miR-193a-5p and Activating TGF-β1/Smad2/3 Signaling
Hu H, Mao G, Zheng J, Guo F
Drug Design, Development and Therapy 2022, 16:4223-4234
Published Date: 8 December 2022
Molecular Mechanisms of Luteolin Against Atopic Dermatitis Based on Network Pharmacology and in vivo Experimental Validation
Tang L, Gao J, Li X, Cao X, Zhou B
Drug Design, Development and Therapy 2022, 16:4205-4221
Published Date: 9 December 2022
Methanolic Extract of Aerva javanica Leaves Prevents LPS-Induced Depressive Like Behavior in Experimental Mice
Arshad HM, Ahmad FUD, Lodhi AH
Drug Design, Development and Therapy 2022, 16:4179-4204
Published Date: 7 December 2022
Canagliflozin Attenuates Hepatic Steatosis and Atherosclerosis Progression in Western Diet-Fed ApoE-Knockout Mice
Zuo Q, Zhang G, He L, Ma S, Ma H, Zhai J, Wang Z, Zhang T, Wang Y, Guo Y
Drug Design, Development and Therapy 2022, 16:4161-4177
Published Date: 6 December 2022
Effect of Remimazolam Tosilate on Respiratory Depression in Elderly Patients Undergoing Gastroscopy: A Multicentered, Prospective, and Randomized Study
Hu B, Jiang K, Shi W, Xiao S, Zhang S, Zhang Y, Zhou Y, Tan C, Tan S, Zou X
Drug Design, Development and Therapy 2022, 16:4151-4159
Published Date: 5 December 2022
Dual-Drug Nanosystem: Etoposide Prodrug and Cisplatin Coloaded Nanostructured Lipid Carriers for Lung Cancer Therapy
Du M, Yin J
Drug Design, Development and Therapy 2022, 16:4139-4149
Published Date: 5 December 2022
Thalidomide Attenuates Skin Lesions and Inflammation in Rosacea-Like Mice Induced by Long-Term Exposure of LL-37
Kang Y, Zhang C, He Y, Zhang Z, Liu H, Wei Z, Yang J
Drug Design, Development and Therapy 2022, 16:4127-4138
Published Date: 2 December 2022
Liquiritin Protects Against Cardiac Fibrosis After Myocardial Infarction by Inhibiting CCL5 Expression and the NF-κB Signaling Pathway
Han X, Yang Y, Zhang M, Li L, Xue Y, Jia Q, Wang X, Guan S
Drug Design, Development and Therapy 2022, 16:4111-4125
Published Date: 2 December 2022
A Novel Ocular Delivery of Brinzolamide Based on Gellan Gum: In vitro and in vivo Evaluation [Retraction]
Sun J, Zhou Z
Drug Design, Development and Therapy 2022, 16:4109-4110
Published Date: 2 December 2022
Remimazolam Tosylate Combined with Low-Dose Propofol Improves Sedation and Safety in Hysteroscopy
Zhang F, Chang H, Qing W, Yu R, Liao Q, Tong J
Drug Design, Development and Therapy 2022, 16:4101-4108
Published Date: 29 November 2022
Evaluation of the Effect of Eslicarbazepine Acetate on the Pharmacokinetics of Perampanel in Rats by Isotope-Dilution-UHPLC-MS/MS
Liu P, An J, Wu H
Drug Design, Development and Therapy 2022, 16:4091-4099
Published Date: 28 November 2022
Effects of Salidroside Combined with Paclitaxel on Proliferation, Migration, and Epithelial Mesenchyme of Colorectal Cancer Cells
Hao Y, Li Z, Chang M, Zhang X
Drug Design, Development and Therapy 2022, 16:4079-4089
Published Date: 28 November 2022
Ropivacaine with Dexmedetomidine or Dexamethasone in a Thoracic Paravertebral Nerve Block Combined with an Erector Spinae Plane Block for Thoracoscopic Lobectomy Analgesia: A Randomized Controlled Trial [Corrigendum]
Yang J, Zhao M, Zhang XR, Wang XR, Wang ZH, Feng XY, Lei YJ, Zhang JW
Drug Design, Development and Therapy 2022, 16:4077-4078
Published Date: 24 November 2022
Integrated Network Pharmacology Analysis and Experimental Validation to Investigate the Molecular Mechanism of Triptolide in the Treatment of Membranous Nephropathy
Zhang PN, Tang JY, Yang KZ, Zheng QY, Dong ZC, Geng YL, Liu YN, Liu WJ
Drug Design, Development and Therapy 2022, 16:4061-4076
Published Date: 23 November 2022
Design, Synthesis and Pharmacological Evaluation of 2-(3-BenzoyI-4-Hydroxy-1,1-Dioxido-2H-Benzo[e][1,2]thiazin-2-yI)-N-(2-Bromophenyl) Acetamide as Antidiabetic Agent
Rashid F, Ahmad M, Ashfaq UA, Al-Mutairi AA, Al-Hussain SA
Drug Design, Development and Therapy 2022, 16:4043-4060
Published Date: 22 November 2022
Coffee and Caffeine Potentiate the Antiamyloidogenic Activity of Melatonin via Inhibition of Aβ Oligomerization and Modulation of theTau-Mediated Pathway in N2a/APP Cells [Retraction]
Zhang L, Zhou Z, Wang Z, Du Y, He Z, Cao C, Zhou S
Drug Design, Development and Therapy 2022, 16:4041-4042
Published Date: 21 November 2022
Design of 1,4-Dihydropyridine Hybrid Benzamide Derivatives: Synthesis and Evaluation of Analgesic Activity and Their Molecular Docking Studies
Akbar I, Radhakrishnan S, Karpakavalli M, Manilal A, Hatamleh AA, Alnafisi BK, Ahamed A, Balasubramani R
Drug Design, Development and Therapy 2022, 16:4021-4039
Published Date: 21 November 2022
Development of a Nanoliposomal Formulation of Erlotinib for Lung Cancer and in vitro/In vivo Antitumoral Evaluation [Retraction]
Zhou X, Tao H, Shi KH
Drug Design, Development and Therapy 2022, 16:4019-4020
Published Date: 18 November 2022
Preparation of Novel Pirfenidone Microspheres for Lung-Targeted Delivery: In vitro and in vivo Study [Retraction]
Li D, Gong L
Drug Design, Development and Therapy 2022, 16:4017-4018
Published Date: 18 November 2022
A Novel Tetrandrine-Loaded Chitosan Microsphere: Characterization and in vivo Evaluation [Retraction]
Guo K, Cang J
Drug Design, Development and Therapy 2022, 16:4015-4016
Published Date: 18 November 2022
A Novel Glycyrrhetinic Acid-Modified Oxaliplatin Liposome for Liver-Targeting and in vitro/vivo Evaluation [Retraction]
Chen J, Jiang H, Wu Y, Li Y, Gao Y
Drug Design, Development and Therapy 2022, 16:4013-4014
Published Date: 18 November 2022
Decoding the Key Functional Combined Components Group and Uncovering the Molecular Mechanism of Longdan Xiegan Decoction in Treating Uveitis
Zheng YX, Wang KX, Chen SJ, Liao MX, Chen YP, Guan DG, Wu J, Xiong K
Drug Design, Development and Therapy 2022, 16:3991-4011
Published Date: 17 November 2022
Preliminary Exploration of Clinical Efficacy and Pharmacological Mechanism of Modified Danggui-Shaoyao San in the Treatment of Depression in Patients with Chronic Kidney Disease
Xia M, Ai N, Pang J
Drug Design, Development and Therapy 2022, 16:3975-3989
Published Date: 16 November 2022
Remimazolam: An Updated Review of a New Sedative and Anaesthetic
Hu Q, Liu X, Wen C, Li D, Lei X
Drug Design, Development and Therapy 2022, 16:3957-3974
Published Date: 15 November 2022
Dose Adjustment of Poly (ADP‑Ribose) Polymerase Inhibitors in Patients with Hepatic or Renal Impairment
Zhao D, Long X, Wang J
Drug Design, Development and Therapy 2022, 16:3947-3955
Published Date: 14 November 2022
ED-71 Prevents Glucocorticoid-Induced Osteoporosis by Regulating Osteoblast Differentiation via Notch and Wnt/β-Catenin Pathways
Rong X, Kou Y, Zhang Y, Yang P, Tang R, Liu H, Li M
Drug Design, Development and Therapy 2022, 16:3929-3946
Published Date: 15 November 2022
Diroximel Fumarate as a Novel Oral Immunomodulating Therapy for Relapsing Forms of Multiple Sclerosis: A Review on the Emerging Data
Hauer L, Sellner J
Drug Design, Development and Therapy 2022, 16:3915-3927
Published Date: 10 November 2022
Metabolomics Provides Insights into Renoprotective Effects of Semaglutide in Obese Mice
Chen X, Chen S, Ren Q, Niu S, Pan X, Yue L, Li Z, Zhu R, Jia Z, Chen X, Zhen R, Ban J
Drug Design, Development and Therapy 2022, 16:3893-3913
Published Date: 9 November 2022
Integrated Microbiome and Metabolome Analysis Reveals Correlations Between Gut Microbiota Components and Metabolic Profiles in Mice with Methotrexate-Induced Hepatoxicity
Wang C, Zhao S, Xu Y, Sun W, Feng Y, Liang D, Guan Y
Drug Design, Development and Therapy 2022, 16:3877-3891
Published Date: 8 November 2022
Comparative Pharmacokinetics and Safety of Imrecoxib, a Novel Selective Cyclooxygenase-2 Inhibitor, in Elderly Healthy Subjects
Yang L, Shen Q, Hu C, Wang Y, Zhu X, Shu S, Luo Z
Drug Design, Development and Therapy 2022, 16:3865-3876
Published Date: 8 November 2022
Screening of Adapalene Microsponges Fabrication Parameters with Insight on the In vitro Biological Effectiveness
Yehia RM, Attia DA, Elmazar MM, El-Nabarawi MA, Teaima MH
Drug Design, Development and Therapy 2022, 16:3847-3864
Published Date: 4 November 2022
Biological Mechanisms and Related Natural Inhibitors of CD36 in Nonalcoholic Fatty Liver
Feng Y, Sun W, Sun F, Yin G, Liang P, Chen S, Liu X, Jiang T, Zhang F
Drug Design, Development and Therapy 2022, 16:3829-3845
Published Date: 4 November 2022
Targeting mTOR Complex 2 in Castration-Resistant Prostate Cancer with Acquired Docetaxel Resistance
Huang Y, Zhai Y, Wu M, Chang C, Luo J, Hong D, Zhao Q, Dai Y, Liu J
Drug Design, Development and Therapy 2022, 16:3817-3828
Published Date: 4 November 2022
Atorvastatin Inhibits High-Fat Diet-Induced Lipid Metabolism Disorders in Rats by Inhibiting Bacteroides Reduction and Improving Metabolism
Li H, Wang S, Wang S, Yu H, Yu W, Ma X, He X
Drug Design, Development and Therapy 2022, 16:3805-3816
Published Date: 2 November 2022
Madecassic Acid Ameliorates the Progression of Osteoarthritis: An in vitro and in vivo Study
Fu X, He S, Wang L, Xue Y, Qiao S, An J, Xia T
Drug Design, Development and Therapy 2022, 16:3793-3804
Published Date: 1 November 2022
Aframomum melegueta Seed Extract with Standardized Content of 6-Paradol Reduces Visceral Fat and Enhances Energy Expenditure in Overweight Adults – A Randomized Double-Blind, Placebo-Controlled Clinical Study
Sudeep HV, Aman K, Jestin TV, Shyamprasad K
Drug Design, Development and Therapy 2022, 16:3777-3791
Published Date: 28 October 2022
Integrated Metabonomics and Network Pharmacology to Reveal the Action Mechanism Effect of Shaoyao Decoction on Ulcerative Colitis
Wu J, Luo Y, Shen Y, Hu Y, Zhu F, Wu J, Liu Y
Drug Design, Development and Therapy 2022, 16:3739-3776
Published Date: 27 October 2022
Switching from a Non-Protease Inhibitor-Based Regimen to the Fixed Dose Combination of Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide in Clinical Practice [Corrigendum]
Ranzenigo M, Gianotti N, Galli L, Poli A, Mastrangelo A, Bruzzesi E, Chiurlo M, Nozza S, Bossolasco S, Spagnuolo V, Mancusi D, Termini R, Carini E, Lazzarin A, Castagna A
Drug Design, Development and Therapy 2022, 16:3737-3738
Published Date: 27 October 2022
An Effective Glucagon-Like Peptide-1 Receptor Agonists, Semaglutide, Improves Sarcopenic Obesity in Obese Mice by Modulating Skeletal Muscle Metabolism
Ren Q, Chen S, Chen X, Niu S, Yue L, Pan X, Li Z, Chen X
Drug Design, Development and Therapy 2022, 16:3723-3735
Published Date: 25 October 2022
Sufentanil Combined with Nalbuphine via Patient-Controlled Intravenous Analgesia After Cesarean Section: A Retrospective Evaluation
Wang L, Wang Y, Ma Y, Mu X, Zhang Z, Wang H, Zheng Z, Nie H
Drug Design, Development and Therapy 2022, 16:3711-3721
Published Date: 21 October 2022
A Review of Population Pharmacokinetic Models of Posaconazole
Ding Q, Huang S, Sun Z, Chen K, Li X, Pei Q
Drug Design, Development and Therapy 2022, 16:3691-3709
Published Date: 20 October 2022
The Mechanism of Alisol B23 Acetate Inhibiting Lung Cancer: Targeted Regulation of CD11b/CD18 to Influence Macrophage Polarization
Chen Y, Lu J, Xie Z, Tang J, Lian X, Li X
Drug Design, Development and Therapy 2022, 16:3677-3689
Published Date: 20 October 2022
Quality of Evidence Supporting the Role of Tripterygium Glycosides for the Treatment of Diabetic Kidney Disease: An Overview of Systematic Reviews and Meta-Analyses [Corrigendum]
Shi H, Deng P, Dong C, Lu R, Si G, Yang T
Drug Design, Development and Therapy 2022, 16:3675-3676
Published Date: 21 October 2022
Chikungunya Vaccine Candidates: Current Landscape and Future Prospects
Schmidt C, Schnierle BS
Drug Design, Development and Therapy 2022, 16:3663-3673
Published Date: 20 October 2022
The Efficacy of Cyclophosphamide Combined with Prednisone in Membranous Nephropathy Patients with Different Cytochrome P450 2B6 Gene Polymorphisms and Analysis of Factors Influencing the Efficacy
Zhang M, Lv Y, Liu H
Drug Design, Development and Therapy 2022, 16:3655-3662
Published Date: 20 October 2022
Impact of Remdesivir on SARS-CoV-2 Clearance in a Real-Life Setting: A Matched-Cohort Study
Spagnuolo V, Voarino M, Tonelli M, Galli L, Poli A, Bruzzesi E, Racca S, Clementi N, Oltolini C, Tresoldi M, Rovere Querini P, Dagna L, Zangrillo A, Ciceri F, Clementi M, Castagna A
Drug Design, Development and Therapy 2022, 16:3645-3654
Published Date: 19 October 2022
Smilax glabra Roxb.: A Review of Its Traditional Usages, Phytochemical Constituents, Pharmacological Properties, and Clinical Applications
Wu H, Wang Y, Zhang B, Li YL, Ren ZX, Huang JJ, Zhang ZQ, Lin ZJ, Zhang XM
Drug Design, Development and Therapy 2022, 16:3621-3643
Published Date: 19 October 2022
Management of Axial Spondyloarthritis – Insights into Upadacitinib
Braun J, Kiltz U, Baraliakos X
Drug Design, Development and Therapy 2022, 16:3609-3620
Published Date: 19 October 2022
Non-Selective Alpha-Blockers Provide More Stable Intraoperative Hemodynamic Control Compared with Selective Alpha1-Blockers in Patients with Pheochromocytoma and Paraganglioma: A Single-Center Retrospective Cohort Study with a Propensity Score-Matched Analysis from China
Yang Y, Zhang J, Fang L, Jia X, Zhang W
Drug Design, Development and Therapy 2022, 16:3599-3608
Published Date: 17 October 2022
Exosomes Derived from Hypoxic Glioma Cells Reduce the Sensitivity of Glioma Cells to Temozolomide Through Carrying miR-106a-5p
Wu P, Guo J, Yang H, Yuan D, Wang C, Wang Z
Drug Design, Development and Therapy 2022, 16:3589-3598
Published Date: 13 October 2022
A Review of Herbal Medicine-Based Phytochemical of Garcinia as Molecular Therapy for Breast Cancer
Triyasa KS, Diantini A, Barliana MI
Drug Design, Development and Therapy 2022, 16:3573-3588
Published Date: 12 October 2022
Semaglutide May Alleviate Hepatic Steatosis in T2DM Combined with NFALD Mice via miR-5120/ABHD6
Li R, Ye Z, She D, Fang P, Zong G, Hu K, Kong D, Xu W, Li L, Zhou Y, Zhang K, Xue Y
Drug Design, Development and Therapy 2022, 16:3557-3572
Published Date: 12 October 2022
The Novel Compounds with Biological Activity Derived from Soil Fungi in the Past Decade
Zhang D, Li S, Fan M, Zhao C
Drug Design, Development and Therapy 2022, 16:3493-3555
Published Date: 12 October 2022
Efficacy of Chloral Hydrate Oral Solution for Sedation in Pediatrics: a Systematic Review and Meta-Analysis [Corrigendum]
Chen Z, Lin M, Huang Z, Zeng L, Huang L, Yu D, Zhang L
Drug Design, Development and Therapy 2022, 16:3491-3492
Published Date: 11 October 2022
Current Perspectives: Evidence to Date on BTK Inhibitors in the Management of Multiple Sclerosis
Carnero Contentti E, Correale J
Drug Design, Development and Therapy 2022, 16:3473-3490
Published Date: 6 October 2022
Recent Updates on the Development of Deuterium-Containing Drugs for the Treatment of Cancer
Belete TM
Drug Design, Development and Therapy 2022, 16:3465-3472
Published Date: 4 October 2022
The Combination of Zinc and Melatonin Enhanced Neuroprotection and Attenuated Neuropathy in Oxaliplatin-Induced Neurotoxicity
Ali M, Aziz T
Drug Design, Development and Therapy 2022, 16:3447-3463
Published Date: 4 October 2022
Preparation, in vitro and in vivo Evaluation of Thermosensitive in situ Gel Loaded with Ibuprofen-Solid Lipid Nanoparticles for Rectal Delivery [Retraction]
Huang CH, Hu PY, Wu QY, Xia MY, Zhang WL, Lei ZQ, Li DX, Zhang GS, Feng JF
Drug Design, Development and Therapy 2022, 16:3445-3446
Published Date: 6 October 2022
Profile of Remimazolam in Anesthesiology: A Narrative Review of Clinical Research Progress
Wang M, Zhao X, Yin P, Bao X, Tang H, Kang X
Drug Design, Development and Therapy 2022, 16:3431-3444
Published Date: 3 October 2022
Predicting Outcome in Combination Treatment of TACE and Camrelizumab for Advanced Hepatocellular carcinoma: Tumor Hypervascularity and Reactive Cutaneous Capillary Endothelial Proliferation
Yin L, Liu KC, Lv WF, Xu SB, Lu D, Zhou CZ, Cheng DL, Gao ZG, Shi CS, Su MX
Drug Design, Development and Therapy 2022, 16:3421-3429
Published Date: 30 September 2022
Remimazolam for the Prevention of Emergence Delirium in Children Following Tonsillectomy and Adenoidectomy Under Sevoflurane Anesthesia: A Randomized Controlled Study
Yang X, Lin C, Chen S, Huang Y, Cheng Q, Yao Y
Drug Design, Development and Therapy 2022, 16:3413-3420
Published Date: 30 September 2022
Continuous Erector Spinae Plane Block Using Programmed Intermittent Bolus Regimen versus Intravenous Patient-Controlled Opioid Analgesia Within an Enhanced Recovery Program After Open Liver Resection in Patients with Coagulation Disorder: A Randomized, Controlled, Non-Inferiority Trial
Wang J, Du F, Ma Y, Shi Y, Fang J, Xv J, Cang J, Miao C, Zhang X
Drug Design, Development and Therapy 2022, 16:3401-3412
Published Date: 30 September 2022
Spotlight on Faricimab in the Treatment of Wet Age-Related Macular Degeneration: Design, Development and Place in Therapy
Nair AA, Finn AP, Sternberg P Jr
Drug Design, Development and Therapy 2022, 16:3395-3400
Published Date: 29 September 2022
Pharmacokinetics of Herb-Drug Interactions of Plumbagin and Tazemetostat in Rats by UPLC-MS/MS
Li H, Wang YJ, Geng XN, Kang YR, Wang YL, Qiu XJ
Drug Design, Development and Therapy 2022, 16:3385-3394
Published Date: 29 September 2022
The Beneficial Effects of Geniposide on Glucose and Lipid Metabolism: A Review
Gao S, Feng Q
Drug Design, Development and Therapy 2022, 16:3365-3383
Published Date: 30 September 2022
Baicalin Alleviates Contrast-Induced Acute Kidney Injury Through ROS/NLRP3/Caspase-1/GSDMD Pathway-Mediated Proptosis in vitro
Li Y, Wang J, Huang D, Yu C
Drug Design, Development and Therapy 2022, 16:3353-3364
Published Date: 28 September 2022
ED50 and ED95 of Propofol Combined with Different Doses of Intravenous Lidocaine for First-Trimester Uterine Aspiration: A Prospective Dose-Finding Study Using Up-and-Down Sequential Allocation Method
Zhang J, Kong L, Ni J
Drug Design, Development and Therapy 2022, 16:3343-3352
Published Date: 28 September 2022
Protective Effects of p-CA Against Acute Liver Damage Induced by LPS/D-GalN in Wistar Albino Rats
Mehdi S, Ahmad FUD, Lodhi AH, Khurshid U, Khalid AA, Sidiq SS, Hussain L, Baig MS
Drug Design, Development and Therapy 2022, 16:3327-3342
Published Date: 28 September 2022
Development and Evaluation of Puerarin Loaded-Albumin Nanoparticles Thermoresponsive in situ Gel for Ophthalmic Delivery
Hu L, Xu Y, Meng H
Drug Design, Development and Therapy 2022, 16:3315-3326
Published Date: 27 September 2022
Network and Experimental Pharmacology to Decode the Action of Wendan Decoction Against Generalized Anxiety Disorder
Jin Q, Li J, Chen GY, Wu ZY, Liu XY, Liu Y, Chen L, Wu XY, Liu Y, Zhao X, Song YH
Drug Design, Development and Therapy 2022, 16:3297-3314
Published Date: 27 September 2022
Synthesis and Bioactivity Evaluation of a Novel 1,2,4-Oxadiazole Derivative in vitro and in 3×Tg Mice
Luo Z, Wang Y, Pang S, Gao S, Liu N, Gao X, Zhang L, Qi X, Yang Y, Zhang L
Drug Design, Development and Therapy 2022, 16:3285-3296
Published Date: 25 September 2022
The Temporal Topography of Central Serous Chorioretinopathy in the Chinchilla Rabbits Induced by Intravenous Injection of Adrenaline: An in vivo Study
Yan W, Long P, Zhang L, Chen M, Zhang Z, Chen T
Drug Design, Development and Therapy 2022, 16:3275-3283
Published Date: 23 September 2022
Non-Inferior Efficacy of Tenofovir Disoproxil to Tenofovir Disoproxil Fumarate in Virologically Suppressed Chronic Hepatitis B Patients
Yim HJ, Kim JH, Cho YK, Kweon YO, Cho HC, Hwang JS, Lee C, Koh MS, Baek YH, Park YM, Lee JH, Kim SU, Kang MK, Park NH, Lee JS, Chon YE, Cheon GJ, Chae HB, Sohn JH, Lim YS
Drug Design, Development and Therapy 2022, 16:3263-3274
Published Date: 23 September 2022
Progress and Challenges of Anti-VEGF Agents and Their Sustained-Release Strategies for Retinal Angiogenesis
Xu M, Fan R, Fan X, Shao Y, Li X
Drug Design, Development and Therapy 2022, 16:3241-3262
Published Date: 22 September 2022
Ibrutinib-Associated Cardiotoxicity: From the Pharmaceutical to the Clinical
Dong R, Yan Y, Zeng X, Lin N, Tan B
Drug Design, Development and Therapy 2022, 16:3225-3239
Published Date: 20 September 2022
Effect of Weight-Adjusted Phenylephrine, Norepinephrine, and Metaraminol for Elective Cesarean Delivery on Neonatal Acid–Base Status: A Randomized Controlled Trial
Liu T, Cheng Z, Zou S, Xu C, Pan S, Zeng H, Shan Y, Feng Y, Zhang H
Drug Design, Development and Therapy 2022, 16:3215-3223
Published Date: 21 September 2022
Combined Treatment of Tanshinone I and Epirubicin Revealed Enhanced Inhibition of Hepatocellular Carcinoma by Targeting PI3K/AKT/HIF-1α
Zhao J, Lin E, Cai C, Zhang M, Li D, Cai S, Zeng G, Yin Z, Wang B, Li P, Hong X, Chen J, Zou B, Li J
Drug Design, Development and Therapy 2022, 16:3197-3213
Published Date: 19 September 2022
The Minimal Clinically Important Differences as Well as Statistical Differences of Main Endpoints are Important in Comparing Postoperative Benefits of Different Analgesic Modalities [Letter]
Tian T, Li XT, Xue FS
Drug Design, Development and Therapy 2022, 16:3195-3196
Published Date: 20 September 2022
Cyclosporine A (0.05%) Ophthalmic Gel in the Treatment of Dry Eye Disease: A Multicenter, Randomized, Double-Masked, Phase III, COSMO Trial
Peng W, Jiang X, Zhu L, Li X, Zhou Q, Jie Y, You Z, Wu M, Jin X, Li X, Zhou S
Drug Design, Development and Therapy 2022, 16:3183-3194
Published Date: 20 September 2022
Metabolomics Combined with Network Pharmacology-Based Strategy to Reveal the Underlying Mechanism of Zhenhuang Submicron Emulsion in Treating Oropharyngeal Mucositis Complications of Radiation Therapy for Head and Neck Cancer
Chen W, Li C, Jin D, Shi Y, Zhang M, Bo M, Qian D, Wang M, Li G
Drug Design, Development and Therapy 2022, 16:3169-3182
Published Date: 17 September 2022
Guanmaitong Granule Attenuates Atherosclerosis by Inhibiting Inflammatory Immune Response in ApoE−/− Mice Fed High-Fat Diet
Yang M, Jiao H, Li Y, Zhang L, Zhang J, Zhong X, Xue Y
Drug Design, Development and Therapy 2022, 16:3145-3168
Published Date: 16 September 2022
Comparison of 3 Rates for the Continuous Infusion of Mivacurium During Ambulatory Vitreoretinal Surgery Under General Anesthesia: A Prospective, Randomized, Controlled Clinical Trial
Zhang Y, Xi C, Yue J, Zhao M, Wang G
Drug Design, Development and Therapy 2022, 16:3133-3143
Published Date: 16 September 2022
Network Pharmacology-Based Combined with Experimental Validation Study to Explore the Underlying Mechanism of Agrimonia pilosa Ledeb. Extract in Treating Acute Myocardial Infarction
Zhang M, Chen J, Wang Y, Kang G, Zhang Y, Han X
Drug Design, Development and Therapy 2022, 16:3117-3132
Published Date: 15 September 2022
Albumin-Fusion Recombinant FIX in the Management of People with Hemophilia B: An Evidence-Based Review
Pasca S, Zanon E
Drug Design, Development and Therapy 2022, 16:3109-3116
Published Date: 15 September 2022
Preclinical Pharmacokinetics, Tissue Distribution and in vitro Metabolism of FHND6091, a Novel Oral Proteasome Inhibitor
Yang X, Liu A, Yang L, Wen T, Wang J, Shi J, Zhou H, Chen Z, Lei M, Zhu Y
Drug Design, Development and Therapy 2022, 16:3087-3107
Published Date: 13 September 2022
Dihydromyricetin Attenuates Cerebral Ischemia Reperfusion Injury by Inhibiting SPHK1/mTOR Signaling and Targeting Ferroptosis
Xie J, Zhang T, Li P, Wang D, Liu T, Xu S
Drug Design, Development and Therapy 2022, 16:3071-3085
Published Date: 11 September 2022
Emerging Therapeutic Strategies of Different Immunotherapy Approaches Combined with PD-1/PD-L1 Blockade in Cervical Cancer
Ge Y, Zhang Y, Zhao KN, Zhu H
Drug Design, Development and Therapy 2022, 16:3055-3070
Published Date: 9 September 2022
Dioscin Regulating Bone Marrow Apoptosis in Aplastic Anemia
Zhang L, Ni R, Li J, Fan L, Song Y, Wang H, Wang A, Liu B
Drug Design, Development and Therapy 2022, 16:3041-3053
Published Date: 8 September 2022
Alpha-Chymotrypsin Protects Against Acute Lung, Kidney, and Liver Injuries and Increases Survival in CLP-Induced Sepsis in Rats Through Inhibition of TLR4/NF-κB Pathway
Senousy SR, Ahmed ASF, Abdelhafeez DA, Khalifa MMA, Abourehab MAS, El-Daly M
Drug Design, Development and Therapy 2022, 16:3023-3039
Published Date: 8 September 2022
Dehydrozingerone Alleviates Hyperalgesia, Oxidative Stress and Inflammatory Factors in Complete Freund’s Adjuvant-Induced Arthritic Rats
Liu C, Li Y, Wen C, Yan Z, Olatunji OJ, Yin Z
Drug Design, Development and Therapy 2022, 16:3015-3022
Published Date: 8 September 2022
Identification of Drug Combination Therapies for SARS-CoV-2: A Molecular Dynamics Simulations Approach
Abdel-Halim H, Hajar M, Hasouneh L, Abdelmalek SMA
Drug Design, Development and Therapy 2022, 16:2995-3013
Published Date: 9 September 2022
Levistilide a Induces Ferroptosis by Activating the Nrf2/HO-1 Signaling Pathway in Breast Cancer Cells
Jing S, Lu Y, Zhang J, Ren Y, Mo Y, Liu D, Duan L, Yuan Z, Wang C, Wang Q
Drug Design, Development and Therapy 2022, 16:2981-2993
Published Date: 7 September 2022
Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Sotagliflozin After Multiple Ascending Doses in Chinese Healthy Subjects
He X, Gao X, Xie P, Liu Y, Bai W, Liu Y, Shi A
Drug Design, Development and Therapy 2022, 16:2967-2980
Published Date: 6 September 2022
Sinomenine Inhibits Orthodontic Tooth Movement and Root Resorption in Rats and Enhances Osteogenic Differentiation of PDLSCs
Li H, Li Y, Zou J, Yang Y, Han R, Zhang J
Drug Design, Development and Therapy 2022, 16:2949-2965
Published Date: 5 September 2022
Oral Selective Estrogen Receptor Degraders (SERDs) in Breast Cancer: Advances, Challenges, and Current Status
Downton T, Zhou F, Segara D, Jeselsohn R, Lim E
Drug Design, Development and Therapy 2022, 16:2933-2948
Published Date: 2 September 2022
Protective Effects of Pioglitazone on Cognitive Impairment and the Underlying Mechanisms: A Review of Literature
Alhowail A, Alsikhan R, Alsaud M, Aldubayan M, Rabbani SI
Drug Design, Development and Therapy 2022, 16:2919-2931
Published Date: 31 August 2022
Characterization of Selective and Potent JAK1 Inhibitors Intended for the Inhaled Treatment of Asthma
Nilsson M, Rhedin M, Hendrickx R, Berglund S, Piras A, Blomgran P, Cavallin A, Collins M, Dahl G, Dekkak B, Ericsson T, Hagberg N, Holmberg AA, Leffler A, Lundqvist AJ, Markou T, Pinkerton J, Rönnblom L, Siu S, Taylor V, Wennberg T, Zervas D, Laurence ADJ, Mitra S, Belvisi MG, Birrell M, Borde A
Drug Design, Development and Therapy 2022, 16:2901-2917
Published Date: 31 August 2022
Effect of Puerarin on Osteogenic Differentiation in vitro and on New Bone Formation in vivo
Yang Y, Chen D, Li Y, Zou J, Han R, Li H, Zhang J
Drug Design, Development and Therapy 2022, 16:2885-2900
Published Date: 27 August 2022
Evolving Role of Silodosin for the Treatment of Urological Disorders – A Narrative Review
Jindan L, Xiao W, Liping X
Drug Design, Development and Therapy 2022, 16:2861-2884
Published Date: 26 August 2022
Effects of Lactobacillus plantarum HFY15 on Lupus Nephritis in Mice by Regulation of the TGF-β1 Signaling Pathway
Cheng L, Yao P, Wang H, Yuan Q, Wang X, Feng W, Sun F, Wang Q
Drug Design, Development and Therapy 2022, 16:2851-2860
Published Date: 26 August 2022
Mahuang Decoction Attenuates Airway Inflammation and Remodeling in Asthma via Suppression of the SP1/FGFR3/PI3K/AKT Axis
Wei L, Gou X, Su B, Han H, Guo T, Liu L, Wang L, Zhang L, Chen W
Drug Design, Development and Therapy 2022, 16:2833-2850
Published Date: 26 August 2022
Tackling Microbial Resistance with Isatin-Decorated Thiazole Derivatives: Design, Synthesis, and in vitro Evaluation of Antimicrobial and Antibiofilm Activity
Kassab RM, Al-Hussain SA, Elleboudy NS, Albohy A, Zaki MEA, Abouzid KAM, Muhammad ZA
Drug Design, Development and Therapy 2022, 16:2817-2832
Published Date: 25 August 2022
Scientific Rationale for Waiving Clinical Efficacy Testing of Biosimilars
Niazi S
Drug Design, Development and Therapy 2022, 16:2803-2815
Published Date: 24 August 2022
SIRT1/FOXO1 Axis-Mediated Hippocampal Angiogenesis is Involved in the Antidepressant Effect of Chaihu Shugan San
Zhang S, Lu Y, Shi W, Ren Y, Xiao K, Chen W, Li L, Zhao J
Drug Design, Development and Therapy 2022, 16:2783-2801
Published Date: 23 August 2022
Ginsenoside Rd Promotes Cardiac Repair After Myocardial Infarction by Modulating Monocytes/Macrophages Subsets Conversion
Zhao T, Wang X, Liu Q, Yang T, Qu H, Zhou H
Drug Design, Development and Therapy 2022, 16:2767-2782
Published Date: 22 August 2022
A Real-World Study on the Effect of Imrecoxib for Patients with Axial Spondyloarthritis
Zong HX, Xu SQ, Wang JX, Chu YR, Chen K, Wang C, Tong WQ, Wang XL
Drug Design, Development and Therapy 2022, 16:2755-2765
Published Date: 22 August 2022
Study on the Mechanism of Improving HIV/AIDS Immune Function with Jian Aikang Concentrated Pill Based on Network Pharmacology Combined with Experimental Validation
Shao C, Wang H, Sang F, Xu L
Drug Design, Development and Therapy 2022, 16:2731-2753
Published Date: 18 August 2022
Sulfasalazine Inhibits Inflammation and Fibrogenesis in Pancreas via NF-κB Signaling Pathway in Rats with Oxidative Stress-Induced Pancreatic Injury [Retraction]
Wang Y, Tian F, Yan M, Fan J, Wang L, Kuang R, Li Y
Drug Design, Development and Therapy 2022, 16:2729-2730
Published Date: 18 August 2022
Recent Advances in Nano-Formulations for Skin Wound Repair Applications
Lin Y, Chen Z, Liu Y, Wang J, Lv W, Peng R
Drug Design, Development and Therapy 2022, 16:2707-2728
Published Date: 16 August 2022
Intravenous Lidocaine Significantly Reduces the Propofol Dose in Elderly Patients Undergoing Gastroscopy: A Randomized Controlled Trial
Hu S, Wang M, Li S, Zhou W, Zhang Y, Shi H, Ye P, Sun J, Liu F, Zhang W, Zheng L, Hou Q, Wang Y, Sun W, Chen Y, Lu Z, Ji Z, Liao L, Lv X, Wang Y, Wang X, Yang H
Drug Design, Development and Therapy 2022, 16:2695-2705
Published Date: 12 August 2022
Prostate Cancer Therapy Using Docetaxel and Formononetin Combination: Hyaluronic Acid and Epidermal Growth Factor Receptor Targeted Peptide Dual Ligands Modified Binary Nanoparticles to Facilitate the in vivo Anti-Tumor Activity
Dong Z, Wang Y, Guo J, Tian C, Pan W, Wang H, Yan J
Drug Design, Development and Therapy 2022, 16:2683-2693
Published Date: 11 August 2022
Efficacy and Safety of Remimazolam Besylate versus Dexmedetomidine for Sedation in Non-Intubated Older Patients with Agitated Delirium After Orthopedic Surgery: A Randomized Controlled Trial [Corrigendum]
Deng Y, Qin Z, Wu Q, Liu L, Yang X, Ju X, Zhang Y, Liu L
Drug Design, Development and Therapy 2022, 16:2681-2682
Published Date: 11 August 2022
Brolucizumab for the Treatment of Degenerative Macular Conditions: A Review of Clinical Studies
Karasavvidou EM, Tranos P, Panos GD
Drug Design, Development and Therapy 2022, 16:2659-2680
Published Date: 9 August 2022
Targeting Indoleamine Dioxygenase and Tryptophan Dioxygenase in Cancer Immunotherapy: Clinical Progress and Challenges
Peng X, Zhao Z, Liu L, Bai L, Tong R, Yang H, Zhong L
Drug Design, Development and Therapy 2022, 16:2639-2657
Published Date: 8 August 2022
Corosolic Acid Protects Rat Chondrocytes Against IL-1β-Induced ECM Degradation by Activating Autophagy via PI3K/AKT/mTOR Pathway and Ameliorates Rat Osteoarthritis
Han H, Chen M, Li Z, Zhou S, Wu Y, Wei J
Drug Design, Development and Therapy 2022, 16:2627-2637
Published Date: 6 August 2022
Comparative Dose–Response Study on the Infusion of Norepinephrine Combined with Crystalloid Coload versus Colloid Coload for Preventing Hypotension During Spinal Anesthesia for Cesarean Delivery
Jin WD, Mao JQ, Liu J, Liang G, Jiang C, Sheng ZM
Drug Design, Development and Therapy 2022, 16:2617-2626
Published Date: 6 August 2022
The Preventive and Therapeutic Effects of Ajwa Date Fruit Extract Against Acute Diclofenac Toxicity-Induced Colopathy: An Experimental Study
Hassan SMA, Aboonq MS, Albadawi EA, Aljehani Y, Abdel-Latif HM, Mariah RA, Shafik NM, Soliman TM, Abdel-Gawad AR, Omran FM, Abdellah WA, Shehata A, Shahada H, Baghdadi HH, Aly HY, Saad A, Nabo MMH, Almilaibary A, Eltahir HM, El Sayed SM, Abu-Elnaga MAM, Elbastawisy YM
Drug Design, Development and Therapy 2022, 16:2601-2616
Published Date: 6 August 2022
Design, Synthesis, and Spectroscopic Studies of Some New α-Aminophosphonate Analogues Derived from 4-Hydroxybenzaldehyde with Special Reference to Anticancer Activity
Ali OM, Alotaibi MT, Zaki YH, Amer HH
Drug Design, Development and Therapy 2022, 16:2589-2599
Published Date: 5 August 2022
The Extract of Ilex cornuta Bark Promotes Bone Healing by Activating Adenosine A2A Receptor
Zheng X, Wang J, Zhou J, Wang D
Drug Design, Development and Therapy 2022, 16:2569-2587
Published Date: 4 August 2022
Pleiotropic Effects of Ticagrelor: Influence on CYP4F2 Gene and Protein Expression in HUVEC and HepG2, and Escherichia coli Bacterial Survival
Meskauskaite U, Andruskeviciute S, Ciapiene I, Giedraitiene A, Lesauskaite V, Tatarunas V
Drug Design, Development and Therapy 2022, 16:2559-2568
Published Date: 4 August 2022
The Flavagline Compound 1-(2-(dimethylamino)acetyl)-Rocaglaol Induces Apoptosis in K562 Cells by Regulating the PI3K/Akt/mTOR, JAK2/STAT3, and MAPK Pathways
Yang X, Wu X, Wu X, Huang L, Song J, Yuan C, He Z, Li Y
Drug Design, Development and Therapy 2022, 16:2545-2557
Published Date: 4 August 2022
Effects of Uremic Clearance Granules on p38 MAPK/NF-κB Signaling Pathway, Microbial and Metabolic Profiles in End-Stage Renal Disease Rats Receiving Peritoneal Dialysis
Li X, Zheng J, Wang J, Tang X, Zhang F, Liu S, Liao Y, Chen X, Xie W, Tang Y
Drug Design, Development and Therapy 2022, 16:2529-2544
Published Date: 3 August 2022
Trimetazidine Reduces Cardiac Fibrosis in Rats by Inhibiting NOX2-Mediated Endothelial-to-Mesenchymal Transition
Chen X, Xia X, Dong T, Lin Z, Du L, Zhou H
Drug Design, Development and Therapy 2022, 16:2517-2527
Published Date: 3 August 2022
Influences of Bifid Triple Viable Capsules Plus Cetirizine on Gut Microbiota and Immune Function in Children with Eczema
Su Z, Kang Y
Drug Design, Development and Therapy 2022, 16:2509-2515
Published Date: 3 August 2022
New Oral Anticoagulants Open New Horizons for Cancer Patients with Venous Thromboembolism
Wumaier K, Li W, Cui J
Drug Design, Development and Therapy 2022, 16:2497-2507
Published Date: 3 August 2022
Anti-Inflammatory Effects and Molecular Mechanisms of Shenmai Injection in Treating Acute Pancreatitis: Network Pharmacology Analysis and Experimental Verification
He Y, Hu C, Liu S, Xu M, Liang G, Du D, Liu T, Cai F, Chen Z, Tan Q, Deng L, Xia Q
Drug Design, Development and Therapy 2022, 16:2479-2495
Published Date: 2 August 2022
Allosteric Binding Sites of the SARS-CoV-2 Main Protease: Potential Targets for Broad-Spectrum Anti-Coronavirus Agents
Alzyoud L, Ghattas MA, Atatreh N
Drug Design, Development and Therapy 2022, 16:2463-2478
Published Date: 2 August 2022
The Role of Histone H3 Methylation in Acute Kidney Injury
Zhao YB, Wei W, Lin XX, Chai YF, Jin H
Drug Design, Development and Therapy 2022, 16:2453-2461
Published Date: 2 August 2022
Efficacy and Safety of Remimazolam Besylate versus Dexmedetomidine for Sedation in Non-Intubated Older Patients with Agitated Delirium After Orthopedic Surgery: A Randomized Controlled Trial
Deng Y, Qin Z, Wu Q, Liu L, Yang X, Ju X, Zhang Y, Liu L
Drug Design, Development and Therapy 2022, 16:2439-2451
Published Date: 1 August 2022
Induction of Apoptosis and Autophagy via sirtuin1- and PI3K/Akt/mTOR-Mediated Pathways by Plumbagin in Human Prostate Cancer Cells [Retraction]
Zhou Z, Li X, He Z, Pan S, Yang Y, Zhang X, Chow K, Yang T, Qiu J, Zhou Q, Tan J, Wang D, Zhou S
Drug Design, Development and Therapy 2022, 16:2437-2438
Published Date: 29 July 2022
Baicalein Inhibits the Progression and Promotes Radiosensitivity of Esophageal Squamous Cell Carcinoma by Targeting HIF-1A
Guo D, Jin J, Liu J, Wang Y, Li D, He Y
Drug Design, Development and Therapy 2022, 16:2423-2436
Published Date: 29 July 2022
Study of the Mechanism of Antiemetic Effect of Lavandula angustifolia Mill. Essential Oil Based on Ca2+/CaMKII/ERK1/2 Pathway
Li J, Wang X, Xun S, Guo Q, Wang Y, Jia Y, Wang W, Wang Y, Li T, Tang T, Zou J, Wang M, Yang M, Wang F, Zhang X, Wang C
Drug Design, Development and Therapy 2022, 16:2407-2422
Published Date: 26 July 2022
A Novel Delivery System of RGD-HSA Loaded GEM/CUR Nanoparticles for the Treatment of Pancreatic Cancer Therapy
Ma T, Jiang JL, Qi WX, Chen JY, Xu HP
Drug Design, Development and Therapy 2022, 16:2395-2406
Published Date: 26 July 2022
Pharmacokinetic Study of Nalbuphine in Surgical Patients Undergoing General Anesthesia with Varying Degrees of Liver Dysfunction
Gao XN, Nie XY, Gao JL, Heng TF, Zhang YQ, Hua L, Sun YQ, Feng ZY, Wang MX, Jia L
Drug Design, Development and Therapy 2022, 16:2383-2393
Published Date: 26 July 2022
Identifying the Antitumor Effects of Curcumin on Lung Adenocarcinoma Using Comprehensive Bioinformatics Analysis
Yang FR, Li SY, Hu XW, Li XR, Li HJ
Drug Design, Development and Therapy 2022, 16:2365-2382
Published Date: 23 July 2022
Icariin and Competing Endogenous RNA Network: A Potential Protective Strategy Against Contrast-Induced Acute Kidney Injury
Lin Y, Zhu G, Li X, Yu H, Luo Y, Lin J, Li R, Huang Z
Drug Design, Development and Therapy 2022, 16:2343-2363
Published Date: 23 July 2022
Theaflavin Alleviates Inflammatory Response and Brain Injury Induced by Cerebral Hemorrhage via Inhibiting the Nuclear Transcription Factor Kappa β-Related Pathway in Rats [Retraction]
Fu G, Wang H, Cai Y, Zhao H, Fu W
Drug Design, Development and Therapy 2022, 16:2341-2342
Published Date: 20 July 2022
A Potent EGFR Inhibitor, N-Phenyl Pyrazoline Derivative Suppresses Aggressiveness and Cancer Stem Cell-Like Phenotype of Cervical Cancer Cells
Mustofa, Satriyo PB, Suma AAT, Waskitha SSW, Wahyuningsih TD, Sholikhah EN
Drug Design, Development and Therapy 2022, 16:2325-2339
Published Date: 20 July 2022
Diosgenin and Its Analogs: Potential Protective Agents Against Atherosclerosis
Wang D, Wang X
Drug Design, Development and Therapy 2022, 16:2305-2323
Published Date: 17 July 2022
Magnesium Lithospermate B Protects Against Cisplatin-Induced Acute Kidney Injury via Alleviating Mitochondrial Dysfunction
Shen D, Guo M, Geng X, Yu J, Zhang Z, Lin J, Lin P, Ding X, Xu X
Drug Design, Development and Therapy 2022, 16:2293-2304
Published Date: 15 July 2022
Development and Evaluation of in-situ Nasal Gel Formulations of Nanosized Transferosomal Sumatriptan: Design, Optimization, in vitro and in vivo Evaluation [Retraction]
Omar MM, Eleraky NE, El Sisi AM, Ali Hasan O
Drug Design, Development and Therapy 2022, 16:2291-2292
Published Date: 15 July 2022
Novel Purine Thioglycoside Analogs: Synthesis, Nanoformulation and Biological Evaluation in in vitro Human Liver and Breast Cancer Models [Retraction]
Abu-Zaied MA, Loutfy SA, Hassan AE, Elgemeie GH
Drug Design, Development and Therapy 2022, 16:2289-2290
Published Date: 15 July 2022
Design, Synthesis, and Anti-Inflammatory Activity of Some Coumarin Schiff Base Derivatives: In silico and in vitro Study
Hamid SJ, Salih T
Drug Design, Development and Therapy 2022, 16:2275-2288
Published Date: 14 July 2022
Population Pharmacokinetic Modelling for Nifedipine to Evaluate the Effect of Parathyroid Hormone on CYP3A in Patients with Chronic Kidney Disease
Fu C, Pei Q, Liang W, Yang B, Li W, Liu J, Tan H, Guo C, Zhang H, Yang G
Drug Design, Development and Therapy 2022, 16:2261-2274
Published Date: 13 July 2022
Paeoniflorin Ameliorates BiPN by Reducing IL6 Levels and Regulating PARKIN-Mediated Mitochondrial Autophagy
Sun R, Liu J, Yu M, Xia M, Zhang Y, Sun X, Xu Y, Cui X
Drug Design, Development and Therapy 2022, 16:2241-2259
Published Date: 13 July 2022
Effects of Dexmedetomidine Administered Through Different Routes on Kidney Tissue in Rats with Spinal Cord Ischaemia–Reperfusion Injury
Şengel N, Köksal Z, Dursun AD, Kurtipek Ö, Sezen ŞC, Arslan M, Kavutçu M
Drug Design, Development and Therapy 2022, 16:2229-2239
Published Date: 13 July 2022
Effects of Super-Activated Platelet Lysate on Early Healing of Tooth Extraction Sockets in Rats
Guo X, Lu H, Liu C, Zhang Y, Bi L
Drug Design, Development and Therapy 2022, 16:2213-2227
Published Date: 13 July 2022
Recent Progress in the Development of Opaganib for the Treatment of Covid-19
Smith CD, Maines LW, Keller SN, Katz Ben-Yair V, Fathi R, Plasse TF, Levitt ML
Drug Design, Development and Therapy 2022, 16:2199-2211
Published Date: 12 July 2022
Comparative Dose-Response Study of Phenylephrine Bolus for the Treatment of the First Episode of Spinal Anesthesia-Induced Hypotension for Cesarean Delivery in Severe Preeclamptic versus Normotensive Parturients
Hu LJ, Mei Z, Shen YP, Sun HT, Sheng ZM, Chen XZ, Qian XW
Drug Design, Development and Therapy 2022, 16:2189-2198
Published Date: 8 July 2022
Senkyunolide A Protects Neural Cells against Corticosterone-Induced Apoptosis by Modulating Protein Phosphatase 2A and α-Synuclein Signaling [Retraction]
Gong S, Zhang J, Guo Z, Fu W
Drug Design, Development and Therapy 2022, 16:2187-2188
Published Date: 12 July 2022
Combination Therapy of Ezetimibe and Rosuvastatin for Dyslipidemia: Current Insights
Chilbert MR, VanDuyn D, Salah S, Clark CM, Ma Q
Drug Design, Development and Therapy 2022, 16:2177-2186
Published Date: 7 July 2022
The Role of Dexmedetomidine in Tumor-Progressive Factors in the Perioperative Period and Cancer Recurrence: A Narrative Review
Cai Q, Liu G, Huang L, Guan Y, Wei H, Dou Z, Liu D, Hu Y, Gao M
Drug Design, Development and Therapy 2022, 16:2161-2175
Published Date: 6 July 2022
Orexin-A Reverse Bone Mass Loss Induced by Chronic Intermittent Hypoxia Through OX1R-Nrf2/HIF-1α Pathway
Gu H, Ru Y, Wang W, Cai G, Gu L, Ye J, Zhang WB, Wang L
Drug Design, Development and Therapy 2022, 16:2145-2160
Published Date: 5 July 2022
Sorafenib Attenuates Fibrotic Hepatic Injury Through Mediating Lysine Crotonylation
Chen XF, Ji S
Drug Design, Development and Therapy 2022, 16:2133-2144
Published Date: 3 July 2022
Palmatine Protects Against MSU-Induced Gouty Arthritis via Regulating the NF-κB/NLRP3 and Nrf2 Pathways
Cheng JJ, Ma XD, Ai GX, Yu QX, Chen XY, Yan F, Li YC, Xie JH, Su ZR, Xie QF
Drug Design, Development and Therapy 2022, 16:2119-2132
Published Date: 2 July 2022
Carbon Monoxide-Releasing Molecule-3 Enhances Osteogenic Differentiation of Rat Bone Marrow Mesenchymal Stem Cells via miR-195-5p/Wnt3a Pathway
Li J, Han Q, Chen H, Liu T, Song J, Hou M, Wei L, Song H
Drug Design, Development and Therapy 2022, 16:2101-2117
Published Date: 2 July 2022
Shikonin Could Be Used to Treat Tubal Pregnancy via Enhancing Ferroptosis Sensitivity
Lai Y, Zeng F, Chen Z, Feng M, Huang Y, Qiu P, Zeng L, Ke Y, Deng G, Gao J
Drug Design, Development and Therapy 2022, 16:2083-2099
Published Date: 1 July 2022
Shaoyao Gancao Decoction Ameliorates Paclitaxel-Induced Peripheral Neuropathy via Suppressing TRPV1 and TLR4 Signaling Expression in Rats
Chen Y, Lu R, Wang Y, Gan P
Drug Design, Development and Therapy 2022, 16:2067-2081
Published Date: 30 June 2022
Spotlight on Lonapegsomatropin Once-Weekly Injection and Its Potential in the Treatment of Growth Hormone Deficiency in Pediatric Patients
Miller BS, Yuen KCJ
Drug Design, Development and Therapy 2022, 16:2055-2066
Published Date: 29 June 2022
Pharmacological Aspects of Natural Quercetin in Rheumatoid Arthritis
Tang M, Zeng Y, Peng W, Xie X, Yang Y, Ji B, Li F
Drug Design, Development and Therapy 2022, 16:2043-2053
Published Date: 29 June 2022
Inhibition of Axitinib on Buspirone Metabolism in vitro and in vivo
Zhang BW, Pang NH, Xu RA, Qu GE, Tang CR
Drug Design, Development and Therapy 2022, 16:2031-2042
Published Date: 30 June 2022
Appropriate Dose of Dapagliflozin Improves Cardiac Outcomes by Normalizing Mitochondrial Fission and Reducing Cardiomyocyte Apoptosis After Acute Myocardial Infarction
Fan ZG, Xu Y, Chen X, Ji MY, Ma GS
Drug Design, Development and Therapy 2022, 16:2017-2030
Published Date: 28 June 2022
Protective Effect of Hedyotis diffusa Willd. Ethanol Extract on Isoniazid-Induced Liver Injury in the Zebrafish Model
Wang X, Zhao J, Zhang R, Liu X, Ma C, Cao G, Wei Y, Yang P
Drug Design, Development and Therapy 2022, 16:1995-2015
Published Date: 27 June 2022
Nano Sized Hydroxyapatite-Polylactic Acid-Vancomycin in Alleviation of Chronic Osteomyelitis
Lv XF, Zhou DM, Sun XH, Zhao Z
Drug Design, Development and Therapy 2022, 16:1983-1993
Published Date: 27 June 2022
Switching from a Non-Protease inhibitor-Based Regimen To the Fixed Dose Combination of Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide in Clinical Practice
Ranzenigo M, Gianotti N, Galli L, Poli A, Mastrangelo A, Bruzzesi E, Chiurlo M, Nozza S, Bossolasco S, Spagnuolo V, Mancusi D, Termini R, Carini E, Lazzarin A, Castagna A
Drug Design, Development and Therapy 2022, 16:1975-1982
Published Date: 27 June 2022
Human Growth Hormone Fragment 176–191 Peptide Enhances the Toxicity of Doxorubicin-Loaded Chitosan Nanoparticles Against MCF-7 Breast Cancer Cells
Habibullah MM, Mohan S, Syed NK, Makeen HA, Jamal QMS, Alothaid H, Bantun F, Alhazmi A, Hakamy A, Kaabi YA, Samlan G, Lohani M, Thangavel N, Al-Kasim MA
Drug Design, Development and Therapy 2022, 16:1963-1974
Published Date: 27 June 2022
Integrating Network Pharmacology and Experimental Verification to Explore the Pharmacological Mechanisms of Aloin Against Gastric Cancer
Gao J, Yang S, Xie G, Pan J, Zhu F
Drug Design, Development and Therapy 2022, 16:1947-1961
Published Date: 20 June 2022
Dietary Supplement of Anoectochilus roxburghii (Wall.) Lindl. Polysaccharides Ameliorates Cognitive Dysfunction Induced by High Fat Diet via “Gut-Brain” Axis
Fu L, Zhu W, Tian D, Tang Y, Ye Y, Wei Q, Zhang C, Qiu W, Qin D, Yang X, Huang Y
Drug Design, Development and Therapy 2022, 16:1931-1945
Published Date: 20 June 2022
Comprehensive Analysis of Metabolic Changes in Male Mice Exposed to Sodium Valproate Based on GC-MS Analysis
Gao Y, Jiang D, Wang C, An G, Zhu L, Cui C
Drug Design, Development and Therapy 2022, 16:1915-1930
Published Date: 17 June 2022
Evaluating Upadacitinib in the Treatment of Moderate-to-Severe Active Ulcerative Colitis: Design, Development, and Potential Position in Therapy
Napolitano M, D'Amico F, Ragaini E, Peyrin-Biroulet L, Danese S
Drug Design, Development and Therapy 2022, 16:1897-1913
Published Date: 17 June 2022
Population Pharmacokinetics of Tigecycline: A Systematic Review
Zhou CC, Huang F, Zhang JM, Zhuang YG
Drug Design, Development and Therapy 2022, 16:1885-1896
Published Date: 17 June 2022
Disease Modifying Therapies for the Management of Children with Spinal Muscular Atrophy (5q SMA): An Update on the Emerging Evidence
Hjartarson HT, Nathorst-Böös K, Sejersen T
Drug Design, Development and Therapy 2022, 16:1865-1883
Published Date: 16 June 2022
Exploration of the Effect and Potential Mechanism of Echinacoside Against Endometrial Cancer Based on Network Pharmacology and in vitro Experimental Verification
Shu W, Wang Z, Zhao R, Shi R, Zhang J, Zhang W, Wang H
Drug Design, Development and Therapy 2022, 16:1847-1863
Published Date: 16 June 2022
Spotlight on Givosiran as a Treatment Option for Adults with Acute Hepatic Porphyria: Design, Development, and Place in Therapy
Majeed CN, Ma CD, Xiao T, Rudnick S, Bonkovsky HL
Drug Design, Development and Therapy 2022, 16:1827-1845
Published Date: 16 June 2022
Evaluation of Different Surface Coating Agents for Selenium Nanoparticles: Enhanced Anti-Inflammatory Activity and Drug Loading Capacity
Mekkawy AI, Fathy M, Mohamed HB
Drug Design, Development and Therapy 2022, 16:1811-1825
Published Date: 13 June 2022
Ginsenoside Rb1 Alleviates Bleomycin-Induced Pulmonary Inflammation and Fibrosis by Suppressing Central Nucleotide-Binding Oligomerization-, Leucine-Rich Repeat-, and Pyrin Domains-Containing Protein Three Inflammasome Activation and the NF-κB Pathway
Liu J, Fan G, Tao N, Feng F, Meng C, Sun T
Drug Design, Development and Therapy 2022, 16:1793-1809
Published Date: 13 June 2022
The Steady-State Comparative Bioavailability of Intramuscular Risperidone ISM and Oral Risperidone: An Open-Label, One-Sequence Study [Corrigendum]
Walling DP, Hassman HA, Anta L, Ochoa L, Ayani I, Martínez J, Gutierro I
Drug Design, Development and Therapy 2022, 16:1791-1792
Published Date: 13 June 2022
Effects of Simvastatin on the Metabolism of Vonoprazan in Rats Both in vitro and in vivo
Hong Y, Dai DP, Cai JP, Wang SH, Wang YR, Zhao FL, Zhou S, Zhou Q, Geng PW, Zhou YF, Xu X, Shi JH, Luo QF
Drug Design, Development and Therapy 2022, 16:1779-1789
Published Date: 9 June 2022
Transferrin-Modified Mangiferin-Loaded SLNs: Preparation, Characterization, and Application in A549 Lung Cancer Cell
Zhou Q, Hou K, Fu Z
Drug Design, Development and Therapy 2022, 16:1767-1778
Published Date: 8 June 2022
Network Pharmacology Analysis and Experimental Validation to Investigate the Mechanism of Total Flavonoids of Rhizoma Drynariae in Treating Rheumatoid Arthritis
Chen G, Luo J, Liu Y, Yu X, Liu X, Tao Q
Drug Design, Development and Therapy 2022, 16:1743-1766
Published Date: 8 June 2022
Research Progress of Liujunzi Decoction in the Treatment of Tumor-Associated Anorexia
Wu X, Dai Y, Nie K
Drug Design, Development and Therapy 2022, 16:1731-1741
Published Date: 7 June 2022
Didymin Ameliorates Liver Fibrosis by Alleviating Endoplasmic Reticulum Stress and Glycerophospholipid Metabolism: Based on Transcriptomics and Metabolomics
Li Y, Li C, Xiong Y, Fang B, Lin X, Huang Q
Drug Design, Development and Therapy 2022, 16:1713-1729
Published Date: 7 June 2022
Anti-Hyperglycemic Agents in the Adjuvant Treatment of Sepsis: Improving Intestinal Barrier Function
Wang YF, Li JW, Wang DP, Jin K, Hui JJ, Xu HY
Drug Design, Development and Therapy 2022, 16:1697-1711
Published Date: 4 June 2022
THSD7B Mutation Induces Platinum Resistance in Small Cell Lung Cancer Patients
Yao Z, Lin A, Yi Y, Shen W, Zhang J, Luo P
Drug Design, Development and Therapy 2022, 16:1679-1695
Published Date: 3 June 2022
The Antithrombotic Effect of Recombinant Neorudin on Thrombi
Liu YB, Zhang L, Zhou XC, Zhou Y, Liu Y, Zheng C, Xu X, Geng PP, Hao CH, Zhao ZY, Wu CT, Jin JD
Drug Design, Development and Therapy 2022, 16:1667-1678
Published Date: 2 June 2022
Quality of Evidence Supporting the Role of Tripterygium Glycosides for the Treatment of Diabetic Kidney Disease: An Overview of Systematic Reviews and Meta-Analyses
Shi H, Deng P, Dong C, Lu R, Si G, Yang T
Drug Design, Development and Therapy 2022, 16:1647-1665
Published Date: 31 May 2022
Network Pharmacology-Based Strategy Combined with Molecular Docking and in vitro Validation Study to Explore the Underlying Mechanism of Huo Luo Xiao Ling Dan in Treating Atherosclerosis
Sun T, Quan W, Peng S, Yang D, Liu J, He C, Chen Y, Hu B, Tuo Q
Drug Design, Development and Therapy 2022, 16:1621-1645
Published Date: 30 May 2022
Astragaloside IV Alleviates Renal Tubular Epithelial-Mesenchymal Transition via CX3CL1-RAF/MEK/ERK Signaling Pathway in Diabetic Kidney Disease
Hu Y, Tang W, Liu W, Hu Z, Pan C
Drug Design, Development and Therapy 2022, 16:1605-1620
Published Date: 31 May 2022
Determination of the Cut-off Value for Imatinib Plasma Levels Linked to Occurrence of Bone Pain in CML Patients
Hamza MS, Shouman SA, Abdelfattah R, Moussa HS, Omran MM
Drug Design, Development and Therapy 2022, 16:1595-1604
Published Date: 30 May 2022
6-Methoxyflavone and Donepezil Behavioral Plus Neurochemical Correlates in Reversing Chronic Ethanol and Withdrawal Induced Cognitive Impairment
Arif M, Rauf K, Rehman NU, Tokhi A, Ikram M, Sewell RD
Drug Design, Development and Therapy 2022, 16:1573-1593
Published Date: 28 May 2022
Ropivacaine with Dexmedetomidine or Dexamethasone in a Thoracic Paravertebral Nerve Block Combined with an Erector Spinae Plane Block for Thoracoscopic Lobectomy Analgesia: A Randomized Controlled Trial
Yang J, Zhao M, Zhang XR, Wang XR, Wang ZH, Feng XY, Lei YJ, Zhang JW
Drug Design, Development and Therapy 2022, 16:1561-1571
Published Date: 26 May 2022
Designing a Dual GLP-1R/GIPR Agonist from Tirzepatide: Comparing Residues Between Tirzepatide, GLP-1, and GIP
Wang L
Drug Design, Development and Therapy 2022, 16:1547-1559
Published Date: 25 May 2022
Reduced the Food Effect and Enhanced the Oral Bioavailability of Ivacaftor by Self-Nanoemulsifying Drug Delivery System (SNEDDS) Using a New Oil Phase
Miao Y, Zhao S, Zuo J, Sun J, Wang J
Drug Design, Development and Therapy 2022, 16:1531-1546
Published Date: 23 May 2022
“PFH/AGM-CBA/HSV-TK/LIPOSOME-Affibody”: Novel Targeted Nano Ultrasound Contrast Agents for Ultrasound Imaging and Inhibited the Growth of ErbB2-Overexpressing Gastric Cancer Cells
Zhou H, Liu H, Zhang Y, Xin Y, Huang C, Li M, Zhao X, Ding P, Liu Z
Drug Design, Development and Therapy 2022, 16:1515-1530
Published Date: 18 May 2022
Design, Synthesis and Biological Evaluation of New 3,4-Dihydro-2(1H)-Quinolinone-Dithiocarbamate Derivatives as Multifunctional Agents for the Treatment of Alzheimer’s Disease
Guo J, Xu A, Cheng M, Wan Y, Wang R, Fang Y, Jin Y, Xie SS, Liu J
Drug Design, Development and Therapy 2022, 16:1495-1514
Published Date: 18 May 2022
Effectiveness and Safety of Anlotinib with or without PD-1 Blockades in the Treatment of Patients with Advanced Primary Hepatocellular Carcinoma: A Retrospective, Real-World Study in China
Chen XQ, Zhao YX, Zhang CL, Wang XT, Zhang X, Chen X, Yuan CW, Zhao Q, Chen XJ
Drug Design, Development and Therapy 2022, 16:1483-1493
Published Date: 17 May 2022
Effects of Ethanolic Extract of Schisandra sphenanthera on the Pharmacokinetics of Rosuvastatin in Rats
Sun Q, Li L, Zhou Q
Drug Design, Development and Therapy 2022, 16:1473-1481
Published Date: 17 May 2022
Novel 2-(5-Aryl-4,5-Dihydropyrazol-1-yl)thiazol-4-One as EGFR Inhibitors: Synthesis, Biological Assessment and Molecular Docking Insights
Al-Warhi T, El Kerdawy AM, Said MA, Albohy A, Elsayed ZM, Aljaeed N, Elkaeed EB, Eldehna WM, Abdel-Aziz HA, Abdelmoaz MA
Drug Design, Development and Therapy 2022, 16:1457-1471
Published Date: 16 May 2022
Silibinin Schiff Base Derivatives Counteract CCl4-Induced Acute Liver Injury by Enhancing Anti-Inflammatory and Antiapoptotic Bioactivities
Xu R, Qiu S, Zhang J, Liu X, Zhang L, Xing H, You M, Wang M, Lu Y, Zhang P, Zhu J
Drug Design, Development and Therapy 2022, 16:1441-1456
Published Date: 16 May 2022
Compatibility and Stability of Ten Commonly Used Clinical Drugs in Pediatric Electrolyte Supplements Injection
Shen H, Fu Y, Chen Y, Xia W, Jia ZJ, Yu Q, Zhang L, Han L
Drug Design, Development and Therapy 2022, 16:1433-1440
Published Date: 12 May 2022
RETRACTED ARTICLE: Preparation, in vitro and in vivo Evaluation of Thermosensitive in situ Gel Loaded with Ibuprofen-Solid Lipid Nanoparticles for Rectal Delivery
Huang CH, Hu PY, Wu QY, Xia MY, Zhang WL, Lei ZQ, Li DX, Zhang GS, Feng JF
Drug Design, Development and Therapy 2022, 16:1407-1431
Published Date: 12 May 2022
Gancao Xiexin Decoction Ameliorates Ulcerative Colitis in Mice via Modulating Gut Microbiota and Metabolites
Luo YT, Wu J, Zhu FY, Wu JQ, Wu P, Liu YC
Drug Design, Development and Therapy 2022, 16:1383-1405
Published Date: 9 May 2022
Pharmacokinetics and Safety of Single and Multiple Doses of Peficitinib (ASP015K) in Healthy Chinese Subjects
Gao X, He X, Oshima H, Miyatake D, Otsuka Y, Kato K, Cai C, Wojtkowski T, Song N, Kaneko Y, Shi A
Drug Design, Development and Therapy 2022, 16:1365-1381
Published Date: 9 May 2022
Network Pharmacology Analysis of Hewei Jiangni Granule for Gastroesophageal Reflux Disease and Experimental Verification of Its Anti-Neurogenic Inflammation Mechanism
Cheng Y, Kou F, Zhang X, Dai Y, Shi L, Xie C, Li X, Li J
Drug Design, Development and Therapy 2022, 16:1349-1363
Published Date: 5 May 2022
Knee Osteoarthritis Therapy: Recent Advances in Intra-Articular Drug Delivery Systems
Ma L, Zheng X, Lin R, Sun AR, Song J, Ye Z, Liang D, Zhang M, Tian J, Zhou X, Cui L, Liu Y, Liu Y
Drug Design, Development and Therapy 2022, 16:1311-1347
Published Date: 4 May 2022
Novel Liposomal Rolipram Formulation for Clinical Application to Reduce Emesis
Gobejishvili L, Rodriguez WE, Bauer P, Wang Y, Soni C, Lydic T, Barve S, McClain C, Maldonado C
Drug Design, Development and Therapy 2022, 16:1301-1309
Published Date: 3 May 2022
Effects of Intravenous Analgesia Using Tramadol on Postoperative Depression State and Sleep Quality in Women Undergoing Abdominal Endoscopic Surgery: A Randomized Controlled Trial
Fu M, Chen S, Xu R, Chen J, Chen X, Gan W, Huang H, Duan G
Drug Design, Development and Therapy 2022, 16:1289-1300
Published Date: 2 May 2022
Isoliquiritigenin Ameliorates Ischemia-Induced Myocardial Injury via Modulating the Nrf2/HO-1 Pathway in Mice
Yao D, Shi B, Wang S, Bao L, Tan M, Shen H, Zhang Z, Pan X, Yang Y, Wu Y, Gong K
Drug Design, Development and Therapy 2022, 16:1273-1287
Published Date: 29 April 2022
The Emerging Potential of Parthenolide Nanoformulations in Tumor Therapy
An T, Yin H, Lu Y, Liu F
Drug Design, Development and Therapy 2022, 16:1255-1272
Published Date: 29 April 2022
Integrated Network Pharmacology and Metabolomics Analysis to Reveal the Potential Mechanism of Siwu Paste on Aplastic Anemia Induced by Chemotherapy Drugs
He D, Dan W, Du Q, Shen BB, Chen L, Fang LZ, Kuang JJ, Tang CY, Cai P, Yu R, Zhang SH, Huang JH
Drug Design, Development and Therapy 2022, 16:1231-1254
Published Date: 28 April 2022
Effects of Cartilage Progenitor Cells, Bone Marrow Mesenchymal Stem Cells and Chondrocytes on Cartilage Repair as Seed Cells: An in vitro Study
Gu J, Wang B, Wang T, Zhang N, Liu H, Gui J, Lu Y
Drug Design, Development and Therapy 2022, 16:1217-1230
Published Date: 28 April 2022
Added Syrup as a Flavoring to Oral Midazolam Intravenous Solution Premedication Improves Tolerability in Pediatric Patients
Xue Q, Xia J, Lu J, Shen X
Drug Design, Development and Therapy 2022, 16:1211-1216
Published Date: 28 April 2022
Quality of Recovery After General Anesthesia with Remimazolam in Patients’ Undergoing Urologic Surgery: A Randomized Controlled Trial Comparing Remimazolam with Propofol
Mao Y, Guo J, Yuan J, Zhao E, Yang J
Drug Design, Development and Therapy 2022, 16:1199-1209
Published Date: 27 April 2022
Gemcitabine Combined with Cisplatin Has a Better Effect in the Treatment of Recurrent/Metastatic Advanced Nasopharyngeal Carcinoma
Yang Q, Nie YH, Cai MB, Li ZM, Zhu HB, Tan YR
Drug Design, Development and Therapy 2022, 16:1191-1198
Published Date: 26 April 2022
Intrathecal Injection of Ropivacaine Reduces Cervical Resistance in Late-Pregnant Rats
Hu Y, Fan LJ, Jiang YM, Liu H, Yong H, Peng C
Drug Design, Development and Therapy 2022, 16:1183-1189
Published Date: 26 April 2022
Effect of Systemic Lidocaine on Postoperative Early Recovery Quality in Patients Undergoing Supratentorial Tumor Resection
Zhao K, Dong Y, Su G, Wang Y, Ji T, Wu N, Cui X, Li W, Yang Y, Chen X
Drug Design, Development and Therapy 2022, 16:1171-1181
Published Date: 22 April 2022
Carvacrol Alleviates Hyperuricemia-Induced Oxidative Stress and Inflammation by Modulating the NLRP3/NF-κB Pathwayt
Riaz M, Al Kury LT, Atzaz N, Alattar A, Alshaman R, Shah FA, Li S
Drug Design, Development and Therapy 2022, 16:1159-1170
Published Date: 22 April 2022
Analagesic and Anti-Inflammatory Potentials of a Less Ulcerogenic Thiadiazinethione Derivative in Animal Models: Biochemical and Histochemical Correlates
Rahman K, Ali G, Khan R, Khan I, Ali I, Mosa OF, Ahmed A, Ayaz M, Nawaz A, Murthy HCA
Drug Design, Development and Therapy 2022, 16:1143-1157
Published Date: 21 April 2022
Global Trends and Hotspots in Esketamine Research: A Bibliometric Analysis of Past and Estimation of Future Trends
Li X, Xiang P, Liang J, Deng Y, Du J
Drug Design, Development and Therapy 2022, 16:1131-1142
Published Date: 21 April 2022
Dezocine Has the Potential to Regulate the Clinical and Biological Features of Tumors
Hu X, Luo B, Qiu L, Chen S, Wu Q, Chen Q, Liu X, Ling C, Deng S, Yuan M, Hu P
Drug Design, Development and Therapy 2022, 16:1121-1129
Published Date: 20 April 2022
Blockade of the P2Y2 Receptor Attenuates Alcoholic Liver Inflammation by Targeting the EGFR-ERK1/2 Signaling Pathway
Liu ZN, Su QQ, Wang YH, Wu X, Lv XW
Drug Design, Development and Therapy 2022, 16:1107-1120
Published Date: 13 April 2022
Ruscogenin Attenuates Lipopolysaccharide-Induced Septic Vascular Endothelial Dysfunction by Modulating the miR-146a-5p/NRP2/SSH1 Axis
Pan D, Zhu J, Cao L, Zhu B, Lin L
Drug Design, Development and Therapy 2022, 16:1099-1106
Published Date: 12 April 2022
Design, Synthesis, and Biological Evaluation of 2-Anilino-4-Triazolpyrimidine Derivatives as CDK4/HDACs Inhibitors
Wang S, Han S, Cheng W, Miao R, Li S, Tian X, Kan Q
Drug Design, Development and Therapy 2022, 16:1083-1097
Published Date: 11 April 2022
Progress on SARS-CoV-2 3CLpro Inhibitors: Inspiration from SARS-CoV 3CLpro Peptidomimetics and Small-Molecule Anti-Inflammatory Compounds
Zhu J, Zhang H, Lin Q, Lyu J, Lu Lu, Chen H, Zhang X, Zhang Y, Chen K
Drug Design, Development and Therapy 2022, 16:1067-1082
Published Date: 8 April 2022
Synergistic Effect of Combined Sub-Tenon Triamcinolone and Intravitreal Anti-VEGF Therapy for Uveitic Macular Edema
Lin D, Hu J, Wu K, Feng K, Zhao X, Lu Q, Ren M, Cao J, Liu R, Dai M, Nan K, Wang Y
Drug Design, Development and Therapy 2022, 16:1055-1066
Published Date: 8 April 2022
Lung-Protective Effects of Lidocaine Infusion on Patients with Intermediate/ High Risk of Postoperative Pulmonary Complications: A Double-Blind Randomized Controlled Trial
Wang X, Guo K, Zhao Y, Li T, Yang Y, Xu L, Liu S
Drug Design, Development and Therapy 2022, 16:1041-1053
Published Date: 8 April 2022
The Therapeutic Effect and the Possible Mechanism of C-Phycocyanin in Lipopolysaccharide and Seawater-Induced Acute Lung Injury
Zhang L, Kong D, Huang J, Wang Q, Shao L
Drug Design, Development and Therapy 2022, 16:1025-1040
Published Date: 6 April 2022
Targets Exploration of Hydroxychloroquine for Pigmentation and Cell Protection Effect in Melanocytes: The Clue for Vitiligo Treatment
Xie B, Chen Y, Hu Y, Zhao Y, Luo H, Xu J, Song X
Drug Design, Development and Therapy 2022, 16:1011-1024
Published Date: 5 April 2022
Programmed Intermittent Epidural Bolus in Comparison with Continuous Epidural Infusion for Uterine Contraction Pain Relief After Cesarean Section: A Randomized, Double-Blind Clinical Trial
Mo X, Zhao T, Chen J, Li X, Liu J, Xu C, Song X
Drug Design, Development and Therapy 2022, 16:999-1009
Published Date: 2 April 2022
Therapeutic Potential of Janus Kinase Inhibitors for the Management of Interstitial Lung Disease
Huo R, Guo Q, Hu J, Li N, Gao R, Mi L, Zhang Z, Liu H, Guo Z, Zhao H, Zhang L, Xu K
Drug Design, Development and Therapy 2022, 16:991-998
Published Date: 2 April 2022
A Dose-Response Relationship Study of Prophylactic Nalbuphine to Reduce Pain During the Awakening Period in Patients Undergoing Laparoscopic Total Hysterectomy: A Randomized, Controlled, Double-Blind Clinical Study
Wang M, Wang D, Zuo J, Liu T, Niu Z, Xie J, Qi D
Drug Design, Development and Therapy 2022, 16:981-990
Published Date: 31 March 2022
Metabolism and Mass Balance in Rats Following Oral Administration of the Novel Antifibrotic Drug Fluorofenidone
Wu W, Cheng Z
Drug Design, Development and Therapy 2022, 16:973-979
Published Date: 30 March 2022
Immunotherapy and CRISPR Cas Systems: Potential Cure of COVID-19?
He X, Zeng XX
Drug Design, Development and Therapy 2022, 16:951-972
Published Date: 30 March 2022
Involvement of Huanglian Jiedu Decoction on Microglia with Abnormal Sphingolipid Metabolism in Alzheimer’s Disease
Qi YY, Heng X, Yao ZY, Qu SY, Ge PY, Zhao X, Ni S, Guo R, Yang NY, Zhang QC, Zhu HX
Drug Design, Development and Therapy 2022, 16:931-950
Published Date: 30 March 2022
Molecular Mechanism Underlying Effects of Wumeiwan on Steroid-Dependent Asthma: A Network Pharmacology, Molecular Docking, and Experimental Verification Study
Lyu M, Wang Y, Chen Q, Qin J, Hou D, Huang S, Shao D, Gong X, Huang G, Zhang S, Zhang Z, Cui H
Drug Design, Development and Therapy 2022, 16:909-929
Published Date: 30 March 2022
Salidroside Protects Acute Kidney Injury in Septic Rats by Inhibiting Inflammation and Apoptosis
Fan H, Su B, Le J, Zhu J
Drug Design, Development and Therapy 2022, 16:899-907
Published Date: 30 March 2022
Efficacy and Prognostic Factors for Response to PD-1 Inhibitors in Advanced Cervical Carcinoma: A Retrospective Study
Cheng M, Wang H, Zhao Y, Li G
Drug Design, Development and Therapy 2022, 16:887-897
Published Date: 29 March 2022
Design, Synthesis and Biological Evaluation of 1,4-Benzenesulfonamide Derivatives as Glyoxalase I Inhibitors
Audat SA, Al-Balas QA, Al-Oudat BA, Athamneh MJ, Bryant-Friedrich A
Drug Design, Development and Therapy 2022, 16:873-885
Published Date: 28 March 2022
Clotrimazole Inhibits HCC Migration and Invasion by Modulating the ERK-p65 Signaling Pathway
Liu X, Gao J, Sun Y, Zhang F, Guo W, Zhang S
Drug Design, Development and Therapy 2022, 16:863-871
Published Date: 29 March 2022
Antidepressant-Like Effect and Mechanism of Ginsenoside Rd on Rodent Models of Depression
Li Y, Wang ML, Zhang B, Fan XX, Tang Q, Yu X, Li LN, Fan AR, Chang HS, Zhang LZ
Drug Design, Development and Therapy 2022, 16:843-861
Published Date: 28 March 2022
Use of Antivirals in SARS-CoV-2 Infection. Critical Review of the Role of Remdesivir
Moreno S, Alcázar B, Dueñas C, González del Castillo J, Olalla J, Antela A
Drug Design, Development and Therapy 2022, 16:827-841
Published Date: 25 March 2022
Co-Administration with Voriconazole Doubles the Exposure of Ruxolitinib in Patients with Hematological Malignancies
Zhao Y, Chen P, Dou L, Li F, Li M, Xu L, Chen J, Jia M, Huang S, Wang N, Luan S, Yang J, Bai N, Liu D
Drug Design, Development and Therapy 2022, 16:817-825
Published Date: 25 March 2022
cRGD Urokinase Liposomes for Thrombolysis in Rat Model of Acute Pulmonary Microthromboembolism
Liang C, Huang T, Zhang X, Rao H, Jin Z, Pan X, Li J, Mo Y, Cai Y, Wu J
Drug Design, Development and Therapy 2022, 16:801-816
Published Date: 25 March 2022
Lycium barbarum Polysaccharide Prevents Cisplatin Induced MLTC-1 Cell Apoptosis and Autophagy via Regulating Endoplasmic Reticulum Stress Pathway [Retraction]
Yang F, Wei Y, Liao B, Wei G, Qin H, Pang X, Wang J
Drug Design, Development and Therapy 2022, 16:799-800
Published Date: 25 March 2022
Comparison of Prophylactic Norepinephrine and Phenylephrine Infusions During Spinal Anaesthesia for Primary Caesarean Delivery in Twin Pregnancies: A Randomized Double-Blinded Clinical Study
Du W, Song Y, Li J, Zhou X, Xu Z, Liu Z
Drug Design, Development and Therapy 2022, 16:789-798
Published Date: 24 March 2022
Yishen Qingli Heluo Granule in the Treatment of Chronic Kidney Disease: Network Pharmacology Analysis and Experimental Validation
Sun X, Huang Y, Zhu S, Yan J, Gan K, Xu Z, Wang S, Kang X, Zhang J, Sun W
Drug Design, Development and Therapy 2022, 16:769-787
Published Date: 24 March 2022
Clinical Characteristics and Risk Factors of Lung Injury Induced by Nab-Paclitaxel
Yoshioka K, Abe M, Shiko Y, Koshikawa K, Kawasaki Y, Iwasawa S, Terada J, Tsushima K, Tatsumi K, Suzuki T
Drug Design, Development and Therapy 2022, 16:759-767
Published Date: 22 March 2022
Efficacy of Nimodipine Combined with Latanoprost in Treating Open-Angle Glaucoma and Its Influence on Ocular Hemodynamics and Visual Field Defects
Duan HP, Liu R
Drug Design, Development and Therapy 2022, 16:749-757
Published Date: 21 March 2022
Effect of Intravenous Infusion of Lidocaine Compared with Ultrasound-Guided Transverse Abdominal Plane Block on the Quality of Postoperative Recovery in Patients Undergoing Laparoscopic Bariatric Surgery
Sun J, Wang S, Wang J, Gao X, Wang G
Drug Design, Development and Therapy 2022, 16:739-748
Published Date: 21 March 2022
Comparing Efficacy of Different Analgesic Modalities in Patients Undergoing Total Knee Arthroplasty [Response To Letter]
Xiao R, Liu LF, Luo YR, Liu C, Jin XB, Zhou W, Xu GH
Drug Design, Development and Therapy 2022, 16:737-738
Published Date: 18 March 2022
Expanding the Clinical Use of CDK4/6 Inhibitors in the Treatment of Hormone Receptor-Positive, HER2-Negative Breast Cancer from Metastatic Setting to Adjuvant Setting
Abdel-Razeq H, Sharaf B
Drug Design, Development and Therapy 2022, 16:727-735
Published Date: 16 March 2022
Changes of Optical Coherence Tomography Biomarkers in Macular Edema Secondary to Retinal Vein Occlusion After Anti-VEGF and Anti-Inflammatory Therapies
Ding X, Hu Y, Yu H, Li Q
Drug Design, Development and Therapy 2022, 16:717-725
Published Date: 15 March 2022
A Systematic Review of the Global Intervention for SARS-CoV-2 Combating: From Drugs Repurposing to Molnupiravir Approval
Ashour NA, Abo Elmaaty A, Sarhan AA, Elkaeed EB, Moussa AM, Erfan IA, Al-Karmalawy AA
Drug Design, Development and Therapy 2022, 16:685-715
Published Date: 15 March 2022
The Role of Glucagon-Like Peptide-1 Receptor Agonists (GLP-1 RA) in Diabetes-Related Neurodegenerative Diseases
Cheng D, Yang S, Zhao X, Wang G
Drug Design, Development and Therapy 2022, 16:665-684
Published Date: 14 March 2022
The Astragaloside IV Derivative LS-102 Ameliorates Obesity-Related Nephropathy
Li Z, Yang W, Yang Y, Wu J, Luo P, Liu Y
Drug Design, Development and Therapy 2022, 16:647-664
Published Date: 14 March 2022
Platelet Rich Plasma and Its Use in Hair Regrowth: A Review
Paichitrojjana A, Paichitrojjana A
Drug Design, Development and Therapy 2022, 16:635-645
Published Date: 10 March 2022
Pharmacokinetics and Pharmacodynamics of YYD601, a Dual Delayed-Release Formulation of Esomeprazole, Following Single and Multiple Doses in Healthy Adult Volunteers Under Fasting and Fed Conditions
Lee HW, Kang WY, Jung W, Gwon MR, Cho K, Yoon YR, Seong SJ
Drug Design, Development and Therapy 2022, 16:619-634
Published Date: 6 March 2022
Determination of the Dose-Response Relationship of Epidural Dexmedetomidine Combined with Ropivacaine for Labor Analgesia
Ni JX, Feng JL, Yao SJ, Ni LF, Song SB, Song CZ, Qian XW, Mei Z, Yu J
Drug Design, Development and Therapy 2022, 16:609-618
Published Date: 6 March 2022
New Series of VEGFR-2 Inhibitors and Apoptosis Enhancers: Design, Synthesis and Biological Evaluation
Abdallah AE, Mabrouk RR, Elnagar MR, Farrag AM, Kalaba MH, Sharaf MH, El-Fakharany EM, Bakhotmah DA, Elkaeed EB, Al Ward MMS
Drug Design, Development and Therapy 2022, 16:587-607
Published Date: 3 March 2022
Alleviating Aspirin-Induced Gastric Injury by Binding Aspirin to β-Lactoglobulin
Chen J, Gong M, Huang Z, Wang F, Wang Y, Hu Z, Zeng Z, Wang Y
Drug Design, Development and Therapy 2022, 16:571-586
Published Date: 1 March 2022
Matrine Exerts Pharmacological Effects Through Multiple Signaling Pathways: A Comprehensive Review
Lin Y, He F, Wu L, Xu Y, Du Q
Drug Design, Development and Therapy 2022, 16:533-569
Published Date: 1 March 2022
Analysis of Acrylamide and Glycidamide in Dried Blood Spot of Smokers Using Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry
Harahap Y, Lahilla AA, Jautan AS, Hafidz A, Sunarsih S
Drug Design, Development and Therapy 2022, 16:521-531
Published Date: 28 February 2022
α-Mangostin Treats Early-Stage Adjuvant-Induced Arthritis of Rat by Regulating the CAP-SIRT1 Pathway in Macrophages
Chen WG, Zhang SS, Pan S, Wang ZF, Xu JY, Sheng XH, Yin Q, Wu YJ
Drug Design, Development and Therapy 2022, 16:509-520
Published Date: 27 February 2022
The Effect of Naringin on the Apoptosis of Degenerative Nucleus Pulposus Cells: A Study on the Function and Mechanism
Yuan Z, Yang Z
Drug Design, Development and Therapy 2022, 16:499-508
Published Date: 26 February 2022
Safety, Pharmacokinetics and Pharmacodynamics of the Selective Glucocorticoid Receptor Modulator Velsecorat (AZD7594) Following Inhalation in Healthy Volunteers
Prothon S, Aurivillius M, Tehler U, Eriksson UG, Aggarwal A, Chen Y
Drug Design, Development and Therapy 2022, 16:485-497
Published Date: 23 February 2022
Noncanonical Wnt5a Signaling Suppresses Hippo/TAZ-Mediated Osteogenesis Partly Through the Canonical Wnt Pathway in SCAPs
Fu Y, Ma D, Fan F, Sun T, Han R, Yang Y, Zhang J
Drug Design, Development and Therapy 2022, 16:469-483
Published Date: 22 February 2022
Comparing Efficacy of Analgesic Modalities in Patients Undergoing Total Knee Arthroplasty [Letter]
Gao Y, Xue FS, Li CW
Drug Design, Development and Therapy 2022, 16:467-468
Published Date: 22 February 2022
Network Pharmacology and Molecular Docking Study of the Chinese Miao Medicine Sidaxue in the Treatment of Rheumatoid Arthritis
Wu N, Yuan T, Yin Z, Yuan X, Sun J, Wu Z, Zhang Q, Redshaw C, Yang S, Dai X
Drug Design, Development and Therapy 2022, 16:435-466
Published Date: 19 February 2022
Pharmacokinetic Drug Interaction Between Amlodipine and Tadalafil: An Open-Label, Randomized, Multiple-Dose Crossover Study in Healthy Male Volunteers
Kim H, Lee SH, Jung J, Hong S, Lim HS
Drug Design, Development and Therapy 2022, 16:425-433
Published Date: 19 February 2022
Protective Effects of Remimazolam on Cerebral Ischemia/Reperfusion Injury in Rats by Inhibiting of NLRP3 Inflammasome-Dependent Pyroptosis
Shi M, Chen J, Liu T, Dai W, Zhou Z, Chen L, Xie Y
Drug Design, Development and Therapy 2022, 16:413-423
Published Date: 18 February 2022
Nintedanib Treatment After Ovulation is an Effective Therapeutic Strategy for the Alleviation of Ovarian Hyperstimulation Syndrome (OHSS) in a Mouse Model
Jiang S, Li W, Zhao X, Chen L, Kuang Y
Drug Design, Development and Therapy 2022, 16:397-411
Published Date: 18 February 2022
Network Pharmacology and Experimental Verification to Explore the Potential Mechanism of Yin-Huo-Tang for Lung Adenocarcinoma Recurrence
Liu D, Lin S, Li Y, Zhou T, Hu K, Li Q
Drug Design, Development and Therapy 2022, 16:375-395
Published Date: 17 February 2022
Evaluating the Therapeutic Potential of Ritlecitinib for the Treatment of Alopecia Areata
Ramírez-Marín HA, Tosti A
Drug Design, Development and Therapy 2022, 16:363-374
Published Date: 17 February 2022
Spray with Nitric Oxide Donor Accelerates Wound Healing: Potential Off-the-Shelf Solution for Therapy?
Igrunkova A, Fayzullin A, Churbanov S, Shevchenko P, Serejnikova N, Chepelova N, Pahomov D, Blinova E, Mikaelyan K, Zaborova V, Gurevich K, Urakov A, Vanin A, Timashev P, Shekhter A
Drug Design, Development and Therapy 2022, 16:349-362
Published Date: 16 February 2022
Emodin-Induced Autophagy Against Cell Apoptosis Through the PI3K/AKT/mTOR Pathway in Human Hepatocytes [Corrigendum]
Zheng X, Yang S, Zhang R, Wang S, Li G, Zhou S
Drug Design, Development and Therapy 2022, 16:345-347
Published Date: 16 February 2022
Curcumin Protects Against Myocardial Infarction-Induced Cardiac Fibrosis via SIRT1 Activation in vivo and in vitro [Corrigendum]
Xiao J, Sheng X, Zhang X, Guo M, Ji X
Drug Design, Development and Therapy 2022, 16:343-344
Published Date: 14 February 2022
Uncovering the Potential Mechanisms of Coptis chinensis Franch. for Serious Mental Illness by Network Pharmacology and Pharmacology-Based Analysis
Qi Y, Ni S, Heng X, Qu S, Ge P, Zhao X, Yao Z, Guo R, Yang N, Zhang Q, Zhu H
Drug Design, Development and Therapy 2022, 16:325-342
Published Date: 9 February 2022
Determining the Minimum Effective Concentration of Ropivacaine in Epidural Anesthesia for Tolerable Pain in Transforaminal Percutaneous Endoscopic Lumbar Discectomy to Avoid Nerve Injury: A Double-Blind Study Using a Biased-Coin Design
Hu B, Li L, Wang H, Ma T, Fu Z, Kang X, Feng Z
Drug Design, Development and Therapy 2022, 16:315-323
Published Date: 9 February 2022
The Role of Progesterone Receptors in Breast Cancer
Li Z, Wei H, Li S, Wu P, Mao X
Drug Design, Development and Therapy 2022, 16:305-314
Published Date: 26 January 2022
Efficacy and Safety Profile of Fostemsavir for the Treatment of People with Human Immunodeficiency Virus-1 (HIV-1): Current Evidence and Place in Therapy
Muccini C, Canetti D, Castagna A, Spagnuolo V
Drug Design, Development and Therapy 2022, 16:297-304
Published Date: 25 January 2022
Feasibility of Catalpol Intranasal Administration and Its Protective Effect on Acute Cerebral Ischemia in Rats via Anti-Oxidative and Anti-Apoptotic Mechanisms
Wang J, Zhang Y, Zhang M, Sun S, Zhong Y, Han L, Xu Y, Wan D, Zhang J, Zhu H
Drug Design, Development and Therapy 2022, 16:279-296
Published Date: 25 January 2022
Discovery of Biomarkers and Potential Mechanisms of Agarwood Incense Smoke Intervention by Untargeted Metabolomics and Network Pharmacology
Dong M, Du H, Li X, Zhang L, Wang X, Wang Z, Jiang H
Drug Design, Development and Therapy 2022, 16:265-278
Published Date: 26 January 2022
Less Well-Known Consequences of the Long-Term Use of Opioid Analgesics: A Comprehensive Literature Review
Kotlińska-Lemieszek A, Żylicz Z
Drug Design, Development and Therapy 2022, 16:251-264
Published Date: 18 January 2022
Inhibition of JNK Phosphorylation by Curcumin Analog C66 Protects LPS-Induced Acute Lung Injury [Corrigendum]
Xiao Z, Xu F, Zhu X, Bai B, Guo L, Liang G, Shan X, Zhang Y, Zhao Y, Zhang B
Drug Design, Development and Therapy 2022, 16:249-250
Published Date: 19 January 2022
Wnt/β-Catenin Participates in the Repair of Acute Respiratory Distress Syndrome-Associated Early Pulmonary Fibrosis via Mesenchymal Stem Cell Microvesicles
Zhang X, Ye L, Tang W, Ji Y, Zheng L, Chen Y, Ge Q, Huang C
Drug Design, Development and Therapy 2022, 16:237-247
Published Date: 19 January 2022
Advances in Engineered Three-Dimensional (3D) Body Articulation Unit Models
Chen Y, Wang Y, Luo SC, Zheng X, Kankala RK, Wang SB, Chen AZ
Drug Design, Development and Therapy 2022, 16:213-235
Published Date: 18 January 2022
Research Progress in the Pharmacological Activities, Toxicities, and Pharmacokinetics of Sophoridine and Its Derivatives
Tang Q, Liu Y, Peng X, Wang B, Luan F, Zeng N
Drug Design, Development and Therapy 2022, 16:191-212
Published Date: 18 January 2022
Current Perspectives in the Treatment of Locally Advanced Basal Cell Carcinoma
Gupta N, Ruiz ES
Drug Design, Development and Therapy 2022, 16:183-190
Published Date: 14 January 2022
Chrysin Attenuates High Glucose-Induced BMSC Dysfunction via the Activation of the PI3K/AKT/Nrf2 Signaling Pathway
Li Y, Wang X
Drug Design, Development and Therapy 2022, 16:165-182
Published Date: 13 January 2022
Dexmedetomidine Combined with Femoral Nerve Block Provides Effective Analgesia Similar to Femoral Nerve Combined with Sciatic Nerve Block in Patients Undergoing Total Knee Arthroplasty: A Randomized Controlled Study
Xiao R, Liu LF, Luo YR, Liu C, Jin XB, Zhou W, Xu GH
Drug Design, Development and Therapy 2022, 16:155-164
Published Date: 13 January 2022
Clinical Utility of Elosulfase Alfa in the Treatment of Morquio A Syndrome
Lee CL, Chuang CK, Chiu HC, Tu RY, Lo YT, Chang YH, Lin SP, Lin HY
Drug Design, Development and Therapy 2022, 16:143-154
Published Date: 10 January 2022
Berbamine Suppresses the Growth of Gastric Cancer Cells by Inactivating the BRD4/c-MYC Signaling Pathway
Li H, Luo K, Yang Z, Chen M, Yang X, Wang J, Ying Y, Wu D, Wang Q
Drug Design, Development and Therapy 2022, 16:129-141
Published Date: 11 January 2022
Comparison of Metaraminol, Phenylephrine, and Norepinephrine Infusion for Prevention of Hypotension During Combined Spinal-Epidural Anaesthesia for Elective Caesarean Section: A Three-Arm, Randomized, Double-Blind, Non-Inferiority Trial
Zhou Y, Yu Y, Chu M, Zhang Y, Yu X, Chen G
Drug Design, Development and Therapy 2022, 16:117-127
Published Date: 7 January 2022
Intramuscular Corticosteroid Therapy in the Treatment of Alopecia Areata: A Time-to-Event Analysis
Chanprapaph K, Pomsoong C, Kositkuljorn C, Suchonwanit P
Drug Design, Development and Therapy 2022, 16:107-116
Published Date: 7 January 2022
Ultrasound-Assisted Extraction of Total Saponins from Aralia taibaiensis: Process Optimization, Phytochemical Characterization, and Mechanism of α-Glucosidase Inhibition
Li H, Zhai B, Sun J, Fan Y, Zou J, Cheng J, Zhang X, Shi Y, Guo D
Drug Design, Development and Therapy 2022, 16:83-105
Published Date: 6 January 2022
Inhibition of CXCR4 in Spinal Cord and DRG with AMD3100 Attenuates Colon-Bladder Cross-Organ Sensitization
Zhang H, Dong X, Yang Z, Zhao J, Lu Q, Zhu J, Li L, Yi S, Xu J
Drug Design, Development and Therapy 2022, 16:67-81
Published Date: 6 January 2022
Promising Natural Products in New Drug Design, Development, and Therapy for Skin Disorders: An Overview of Scientific Evidence and Understanding Their Mechanism of Action
Mohd Zaid NA, Sekar M, Bonam SR, Gan SH, Lum PT, Begum MY, Mat Rani NNI, Vaijanathappa J, Wu YS, Subramaniyan V, Fuloria NK, Fuloria S
Drug Design, Development and Therapy 2022, 16:23-66
Published Date: 6 January 2022
Population Pharmacokinetics and Dosing Optimization of Gentamicin in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy
He S, Cheng Z, Xie F
Drug Design, Development and Therapy 2022, 16:13-22
Published Date: 6 January 2022
Open-Label, Phase I, Pharmacokinetic Studies in Healthy Chinese Subjects to Evaluate the Bioequivalence and Food Effect of a Novel Formulation of Abiraterone Acetate Tablets
Feng Z, Liu Y, Kuang Y, Yang S, Li J, Ye L, Huang J, Pei Q, Huang Y, Yang G
Drug Design, Development and Therapy 2022, 16:3-12
Published Date: 3 January 2022
Fatostatin in Combination with Tamoxifen Induces Synergistic Inhibition in ER-Positive Breast Cancer [Corrigendum]
Liu Y, Zhang N, Zhang H, Wang L, Duan Y, Wang X, Chen T, Liang Y, Li Y, Song X, Li C, Han D, Chen B, Zhao W, Yang Q
Drug Design, Development and Therapy 2022, 16:1-2
Published Date: 5 January 2022