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Drug Design, Development and Therapy
Open access peer-reviewed scientific and medical journals.
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Drug Design, Development and Therapy
(591,484) Views
Editor in Chief Daniel S Pilch, PhD
1177-8881
Original ResearchTreatment of glioblastoma multiforme cells with temozolomide-BioShuttle ligated by the inverse Diels-Alder ligation chemistry
Klaus Braun, Manfred Wiessler, Volker Ehemann, Ruediger Pipkorn, Herbert Spring, et al
Drug Design, Development and Therapy 2008, 2:289-301
04 January 2009
Review
Raltegravir in the management of HIV-infected patients
Hans-Jürgen Stellbrink
Drug Design, Development and Therapy 2008, 2:281-288
23 December 2008
Review
Ambrisentan for the treatment of pulmonary arterial hypertension
Brian Casserly, James R Klinger
Drug Design, Development and Therapy 2008, 2:265-280
04 December 2008
Review
Drug design with Cdc7 kinase: a potential novel cancer therapy target
Masaaki Sawa, Hisao Masai
Drug Design, Development and Therapy 2008, 2:255-264
18 November 2008
Review
Once-daily transdermal rivastigmine in the treatment of Alzheimer’s disease
Andreas Wentrup, Wolfgang H Oertel, Richard Dodel
Drug Design, Development and Therapy 2008, 2:245-254
11 November 2008
Review
Development and targeted use of nilotinib in chronic myeloid leukemia
Carmen Fava, Hagop Kantarjian, Jorge Cortes, Elias Jabbour
Drug Design, Development and Therapy 2008, 2:233-243
10 November 2008
Original Research
Antidiabetic Bis-Maltolato-OxoVanadium(IV): Conversion of inactive trans- to bioactive cis-BMOV for possible binding to target PTP-1B
Thomas Scior, Hans-Georg Mack, José Antonio Guevara García, Wolfhard Koch
Drug Design, Development and Therapy 2008, 2:221-231
18 November 2008
Case report
Severe toxicity of skin rash, fever and diarrhea associated with imatinib: case report and review of skin toxicities associated with tyrosine kinase inhibitors
Xuan Huang, Samir Patel, Nasir Ahmed, Karen Seiter, Delong Liu
Drug Design, Development and Therapy 2008, 2:215-219
27 October 2008
Review
Review of pramlintide as adjunctive therapy in treatment of type 1 and type 2 diabetes
Gina Ryan, Tim A Briscoe, Lynette Jobe
Drug Design, Development and Therapy 2008, 2:203-214
16 October 2008
Review
Transdermal hormone therapy in postmenopausal women: A review of metabolic effects and drug delivery technologies
Nathan W Kopper, Jennifer Gudeman
Drug Design, Development and Therapy 2008, 2:193-202
10 October 2008
Review
Next-generation anthracycline for the management of small cell lung cancer: focus on amrubicin
Michiko Yamamoto, Akira Takakura, Noriyuki Masuda
Drug Design, Development and Therapy 2008, 2:189-192
28 September 2008
Review
Polyethylenimine-mediated gene delivery to the lung and therapeutic applications
Sante Di Gioia, Massimo Conese
Drug Design, Development and Therapy 2008, 2:163-188
19 September 2008
Review
Maraviroc in the treatment of HIV infection
Neelanjana Ray
Drug Design, Development and Therapy 2008, 2:151-161
20 August 2008
Original Research
Surface activity of surfactant spiked with vitamin A
Vadim Bronshtein, Vugranam Venkatesh, Jas Aulakh, Philippe Chessex
Drug Design, Development and Therapy 2008, 2:145-150
14 August 2008
Expert Opinion
Comparative in vivo bioequivalence and in vitro dissolution of two valproic acid sustained-release formulations
Akira Fujii, Norio Yasui-Furukori, Taku Nakagami, Takenori Niioka, Manabu Saito, et al
Drug Design, Development and Therapy 2008, 2:139-144
11 August 2008
Review
Submucosal injection solution for gastrointestinal tract endoscopic mucosal resection and endoscopic submucosal dissection
Toshio Uraoka, Yutaka Saito, Kazuhide Yamamoto, Takahiro Fujii
Drug Design, Development and Therapy 2008, 2:131-138
11 August 2008
Original Research
Structure-based design of anticancer prodrug PABA/NO
Xinhua Ji, Ajai Pal, Ravi Kalathur, Xun Hu, Yijun Gu, et al
Drug Design, Development and Therapy 2008, 2:123-130
11 August 2008
Review
Gene medicine for cancer treatment: Commercially available medicine and accumulated clinical data in China
Guangyu Ma, Hideaki Shimada, Kenzo Hiroshima, Yuji Tada, Nobuo Suzuki, Masatoshi Tagawa
Drug Design, Development and Therapy 2008, 2:115-122
11 August 2008
Original Research
A phase I clinical study of VB4-845: Weekly intratumoral administration of an anti-EpCAM recombinant fusion protein in patients with squamous cell carcinoma of the head and neck
Glen C MacDonald, Michèle Rasamoelisolo, Joycelyn Entwistle, Jeannick Cizeau, Denis Bosc, et al
Drug Design, Development and Therapy 2008, 2:105-114
25 June 2008
Pharmacological control of neutrophil-mediated inflammation: Strategies targeting calcium handling by activated polymorphonuclear leukocytes
Gregory R Tintinger, Helen C Steel, Annette J Theron, Ronald Anderson
Drug Design, Development and Therapy 2008, 2:95-104
21 May 2008
Changes in CD4+ T-cells and HIV RNA resulting from combination of anti-TB therapy with Dzherelo in TB/HIV dually infected patients
Lyudmila G Nikolaeva, Tatyana V Maystat, Lilia A Masyuk, Volodymyr S Pylypchuk, Yuri L Volyanskii, Galyna A Kutsyna
Drug Design, Development and Therapy 2008, 2:87-93
01 May 2008
Review
Modafinil in the treatment of excessive sleepiness
Jonathan RL Schwartz
Drug Design, Development and Therapy 2008, 2:71-85
20 May 2008
Induction of cytotoxicity, apoptosis and cell cycle arrest by 1-t-butyl carbamoyl, 7-methyl-indole-3-ethyl isothiocyanate (NB7M) in nervous system cancer cells
Laurent Brard, Rakesh K Singh, Kyu Kwang Kim, Thilo S Lange, Giselle L Saulier Sholler
Drug Design, Development and Therapy 2008, 2:61-69
09 April 2008
Review
Discovery, development, and clinical application of sugammadex sodium, a selective relaxant binding agent
Mark Welliver, John McDonough, Nicholas Kalynych, Robert Redfern
Drug Design, Development and Therapy 2008, 2:49-59
25 February 2008
Optimization of experimental parameters for the production of LMWH-loaded polymeric microspheres
Nusrat Motlekar, Bi-Botti Youan
Drug Design, Development and Therapy 2008, 2:39-47
08 January 2008
Outcome of anthroposophic medication therapy in chronic disease: A 12-month prospective cohort study
Harald J Hamre, Claudia M Witt, Anja Glockmann, Renatus Ziegler, Gunver S Kienle et al
Drug Design, Development and Therapy 2008, 2:25-37
08 January 2008
A safety-modified SV40 Tag developed for human cancer immunotherapy
Stephanie S Tseng-Rogenski, Mohamed S Arredouani, June F Escara-Wilke, Yilin C Neeley, Michael J Imperiale et al
Drug Design, Development and Therapy 2008, 2:17-24
08 January 2008
Pharmaco-management of inhalation injuries for burn survivors
Anthony C Bartley, Dale W Edgar, Fiona M Wood
Drug Design, Development and Therapy 2008, 2:9-16
08 January 2008
Aerosol delivery by an ultrasonic nebulizer during different mechanical ventilation settings in a lung model – a pilot study
Michael Winterhalter, Michael Bund, Nawid Khaladj, Christian Hagl, Andre Simon, et al
Drug Design, Development and Therapy 2008, 2:1-7
08 January 2008
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