Huang C, Du X, Xue L, Song L, Liu X, Chen Z, Wang X, Qin M, Sun X, Wang D, Yang J, Li D, Jiang H, Ding W, Qu Y, Zhu Z, Zhao L, Yuan J, Dong J, Wu D, Hu S, Miao L

Drug Design, Development and Therapy 2026, 20:593835

Published Date: 22 July 2026

Letter

Risk of Bone Mineral Density Loss Associated with GLP-1 Receptor Agonists in Overweight COPD Populations [Letter]

Hong Y, Liu J

Drug Design, Development and Therapy 2026, 20:640490

Published Date: 22 July 2026

Letter

Clinical Applicability of Early Hemidiaphragmatic Paralysis Monitoring After Supraclavicular Brachial Plexus Block [Letter]

Hong Y

Drug Design, Development and Therapy 2026, 20:640957

Published Date: 22 July 2026

Letter

Methodological Considerations in the Bioequivalence Assessment of Recombinant Human Serum Albumin [Letter]

Chang P, Shen D

Drug Design, Development and Therapy 2026, 20:639670

Published Date: 22 July 2026

Review

Deciphering the Multi-Target Therapeutic Mechanisms of Traditional Chinese Medicine Against Alzheimer’s Disease: A Network Pharmacology Perspective

Zhang Y, Qin G, Lian Q, Sun Y, Liu Z, Chen B, Li Z, Li N, Song R, Wang Y

Drug Design, Development and Therapy 2026, 20:597886

Published Date: 22 July 2026

Letter

Methodological Considerations on the Longitudinal Analysis of Polymyxin B‑Induced Kidney Injury [Letter]

Han C, Wang Y, Guo S

Drug Design, Development and Therapy 2026, 20:639804

Published Date: 21 July 2026

Original Research

Toward Model-Informed Precision Dosing of Imipenem: Multicenter External Validation of Population Pharmacokinetic Models in Adult Critically Ill Patients

Zhang P, Pang X, Chen H, Zhu J, Liang G, Yang Y, Zhang X, Yu Z

Drug Design, Development and Therapy 2026, 20:617895

Published Date: 21 July 2026

Clinical Trial Report

Comparison of Incidence of Respiratory Depression Between Ciprofol versus Propofol for Procedural Sedation During First-Trimester Surgical Abortion: A Randomized Controlled Trial

Chen J, Zhang T, Zhang C, Xia L, Zeng L, Zhu Y, Zhu J, Wang Y, Hua F, Liang W

Drug Design, Development and Therapy 2026, 20:604735

Published Date: 21 July 2026

Original Research

Short-Term Glycemic Outcomes Associated with Imeglimin Use Among Patients with Type 2 Diabetes Mellitus: A Prospective Observational Study

Kandasamy G, Selvaraj L, Orayj K, Almanasef M, Asiri R, Alshahrani AM, Alshulah FN, Vasudevan R, Alzaydani AA, Velmani R

Drug Design, Development and Therapy 2026, 20:601458

Published Date: 18 July 2026

Clinical Trial Report

The Effect of Food on the Pharmacokinetics and Gastrointestinal Tolerability of Bersiporocin, a Novel Oral Prolyl-tRNA-Synthetase Inhibitor

Lee S, Kwak Y, Park J, Park Y, Yu KS, Oh J

Drug Design, Development and Therapy 2026, 20:609676

Published Date: 17 July 2026

Clinical Trial Report

Comparison of the ED90 of Esketamine for Suppressing Laryngeal Mask Airway Insertion Responses During Propofol Induction with or without Intravenous Lidocaine Pretreatment: A Randomized Double-Blind Dose-Finding Trial

Zhang L, Zhang L, Wang J, Diao S, Liu Y, Shi J

Drug Design, Development and Therapy 2026, 20:609448

Published Date: 16 July 2026

Original Research

Safety of Short-T erm Low-Dose Olanzapine in Patients with Cancer and Diabetes Receiving Cisplatin-Based Chemotherapy: A Retrospective TriNetX Cohort Study

Hayashi T, Shiraishi C, Abe M, Kaneshige S, Egawa T

Drug Design, Development and Therapy 2026, 20:615968

Published Date: 16 July 2026

Clinical Trial Report

The Effect of Esketamine on Peripheral Vascular Resistance in Elderly Patients During Anesthesia Induction: A Single-Center, Double-Blind, Prospective, Randomized Controlled Study

Li J, Gao Y, Jing K, Lu H, Cao Y, Chen X, Wang H, Song X, Gan G, Tan S

Drug Design, Development and Therapy 2026, 20:607757

Published Date: 16 July 2026

Review

Bicaudal‑C1 in Cancer: Molecular Mechanisms and Therapeutic Strategies Integrating Chinese and Western Medicine

Jiang X, Qi Y, Yan J, Liu Y, Huang X, Li Y, Li Y, Song Z, Zhang L, Zhang Z

Drug Design, Development and Therapy 2026, 20:606851

Published Date: 15 July 2026

Original Research

Obinutuzumab as a Rescue and Maintenance Strategy in Children with Difficult-to-Treat Nephrotic Syndrome After Rituximab-Based Treatment Failure or Intolerance: A Preliminary Single-Center Real-World Retrospective Study

Sun H, Guo L, Shao P, Liang W, Ma X, He Y, Qiu L

Drug Design, Development and Therapy 2026, 20:619807

Published Date: 15 July 2026

Original Research

Early Detection and Temporal Progression of Hemidiaphragmatic Paralysis After Supraclavicular Brachial Plexus Block with 20 mL vs 30 mL Ropivacaine: A Randomized Controlled Trial

Bao X, He Z, Ma Y, Xu S, Hu B, Ma Y, Fang Y, Zhu W, Kang X

Drug Design, Development and Therapy 2026, 20:598288

Published Date: 15 July 2026

Original Research

Comparative Risk of Psoriatic Arthritis in Type 2 Diabetes: An Emulated Target Trial of SGLT2 Inhibitors vs. GLP-1 Receptor Agonists

Yen FS, Wang SI, Hwu CM, Chen KY, Hsu CC, Wei JCC

Drug Design, Development and Therapy 2026, 20:614222

Published Date: 15 July 2026

Letter

Methodological Concerns Regarding ED95 Estimation and Outcome Interpretation in the Remimazolam Dose-Finding Study for HIFU Ablation [Letter]

Yu S, Meng J, Li J

Drug Design, Development and Therapy 2026, 20:637737

Published Date: 14 July 2026

Original Research

Real-World Comparative Weight Loss of GLP-1 Receptor Agonists in the All of Us Research Program: A Retrospective Cohort Study

Hwang I, Lee SW, Kim Y

Drug Design, Development and Therapy 2026, 20:604247

Published Date: 14 July 2026

Review

Targeting Bruton’s Tyrosine Kinase (BTK) in Autoimmunity: Achievements, Opportunities and Challenges

Torke S, Dybowski S, Weber MS

Drug Design, Development and Therapy 2026, 20:568214

Published Date: 14 July 2026

Clinical Trial Report

Effect of Oliceridine on the Acute Postoperative Pain Management After Elective Cesarean Delivery: A Randomized Non-Inferiority Trial

Jiang J, Yuan G, Shi Y, Zhou Z, Wang X, Sang X, Zhang X

Drug Design, Development and Therapy 2026, 20:603352

Published Date: 14 July 2026

Review

Tumor Assembloids as Three-Dimensional Platforms for Modeling Drug Delivery Barriers: Construction Strategies, Applications, and Translational Challenges

Zhang J, Luo X, Sun Z, Jin B, Zhao Y

Drug Design, Development and Therapy 2026, 20:618870

Published Date: 14 July 2026

Original Research

Oliceridine versus Sufentanil on Postoperative Nausea and Vomiting in Women Undergoing Gynecological Laparoscopic Surgery: A Randomized Double‑Blind Controlled Trial

Liu F, Liu N, Wang X, Liu Z, Tao Z, Yuan Q, Zhang Y, Guan Z, Shen W, Tang B, Liu Z, Yang L

Drug Design, Development and Therapy 2026, 20:621409

Published Date: 14 July 2026

Clinical Trial Report

Perioperative Butorphanol for the Prevention of Postoperative Pulmonary Complications After Thoracoscopic Lung Resection: A Randomized, Double-Blind, Placebo-Controlled Trial

Wang X, Zhang Y, Wu Y, Yin T, Xia J, Zhao L, Zeng S, Wu K, Sun J, Liu S

Drug Design, Development and Therapy 2026, 20:621698

Published Date: 14 July 2026

Clinical Trial Report

Dexamethasone Alone versus Combined with Droperidol for Preventing Postoperative Nausea and Vomiting in Gynecological Day Surgery Under Ciprofol-Alfentanil Anesthesia: A Randomized Double-Blind Controlled Trial

Sun X, Xiao H, Li M, Yin B, Yu S, Ji F, Shan J

Drug Design, Development and Therapy 2026, 20:625824

Published Date: 14 July 2026

Original Research

The MEC90 of Ropivacaine for Ultrasound-Guided Pectoral Nerve Block Type II for Modified Radical Mastectomy: A Biased-Coin Up-and-Down Sequential Trial

Du Y, Liu W, Wu Y, Ma L, Tang Y, Wang J

Drug Design, Development and Therapy 2026, 20:612421

Published Date: 13 July 2026

Original Research