Back to Browse Journals » International Journal of Nanomedicine » Volume 7

Design and application of chitosan microspheres as oral and nasal vaccine carriers: an updated review

Authors Islam MA, Firdous J, Choi YJ, Yun CH, Cho CS

Published Date December 2012 Volume 2012:7 Pages 6077—6093

DOI http://dx.doi.org/10.2147/IJN.S38330

Received 20 September 2012, Accepted 27 October 2012, Published 13 December 2012

Mohammad Ariful Islam,1–3,* Jannatul Firdous,1–3,* Yun-Jaie Choi,1 Cheol-Heui Yun,1–4 Chong-Su Cho1,2

1Department of Agricultural Biotechnology, 2Research Institute for Agriculture and Life Sciences, 3Center for Food and Bioconvergence, 4World Class University Biomodulation Program, Seoul National University, Seoul, South Korea

*These authors contributed equally to this work

Abstract: Chitosan, a natural biodegradable polymer, is of great interest in biomedical research due to its excellent properties including bioavailability, nontoxicity, high charge density, and mucoadhesivity, which creates immense potential for various pharmaceutical applications. It has gelling properties when it interacts with counterions such as sulfates or polyphosphates and when it crosslinks with glutaraldehyde. This characteristic facilitates its usefulness in the coating or entrapment of biochemicals, drugs, antigenic molecules as a vaccine candidate, and microorganisms. Therefore, chitosan together with the advance of nanotechnology can be effectively applied as a carrier system for vaccine delivery. In fact, chitosan microspheres have been studied as a promising carrier system for mucosal vaccination, especially via the oral and nasal route to induce enhanced immune responses. Moreover, the thiolated form of chitosan is of considerable interest due to its improved mucoadhesivity, permeability, stability, and controlled/extended release profile. This review describes the various methods used to design and synthesize chitosan microspheres and recent updates on their potential applications for oral and nasal delivery of vaccines. The potential use of thiolated chitosan microspheres as next-generation mucosal vaccine carriers is also discussed.

Keywords: chitosan microspheres, oral, nasal, vaccine delivery, mucosal and systemic immune responses

Download Article [PDF] View Full Text [HTML] 

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php

Readers of this article also read:

Chitosan-coated boron nitride nanospheres enhance delivery of CpG oligodeoxynucleotides and induction of cytokines

Zhang H, Chen S, Zhi C, Yamazaki T, Hanagata N

International Journal of Nanomedicine 2013, 8:1783-1793

Published Date: 6 May 2013

Enhanced oral absorption of 20(S)-protopanaxadiol by self-assembled liquid crystalline nanoparticles containing piperine: in vitro and in vivo studies

Jin X, Zhang ZH, Sun E, Tan XB, Li SL, Cheng XD, You M, Jia XB

International Journal of Nanomedicine 2013, 8:641-652

Published Date: 12 February 2013

A novel drug–phospholipid complex enriched with micelles: preparation and evaluation in vitro and in vivo

Xia HJ, Zhang ZH, Jin X, Hu Q, Chen XY, Jia XB

International Journal of Nanomedicine 2013, 8:545-554

Published Date: 4 February 2013

Oxidative stress-mediated antibacterial activity of graphene oxide and reduced graphene oxide in Pseudomonas aeruginosa

Gurunathan S, Han JW, Dayem AA, Eppakayala V, Kim JH

International Journal of Nanomedicine 2012, 7:5901-5914

Published Date: 30 November 2012

Polyacrylonitrile nanofibers coated with silver nanoparticles using a modified coaxial electrospinning process

Yu DG, Zhou J, Chatterton NP, Li Y, Huang J, Wang X

International Journal of Nanomedicine 2012, 7:5725-5732

Published Date: 12 November 2012

New chitosan nanobubbles for ultrasound-mediated gene delivery: preparation and in vitro characterization

Cavalli R, Bisazza A, Trotta M, Argenziano M, Civra A, Donalisio M, Lembo D

International Journal of Nanomedicine 2012, 7:3309-3318

Published Date: 29 June 2012

Biocompatibility of Fe3O4@Au composite magnetic nanoparticles in vitro and in vivo

Li Y, Liu J, Zhong Y, Zhang J, Wang Z, Wang L, An Y, Lin M, Gao Z, Zhang D

International Journal of Nanomedicine 2011, 6:2805-2819

Published Date: 9 November 2011

Targeted delivery of doxorubicin-utilizing chitosan nanoparticles surface-functionalized with anti-Her2 trastuzumab

Yousefpour P, Atyabi F, Vasheghani-Farahani E, Mousavi Movahedi AA, Dinarvand R

International Journal of Nanomedicine 2011, 6:1977-1990

Published Date: 14 September 2011