Back to Browse Journals » Breast Cancer: Targets and Therapy » Volume 3

Cancer biomarker HER-2/neu in breast cancer in Indian women

Authors Singhai R, Patil VW, Patil AV

Published Date March 2011 Volume 2011:3 Pages 21—26

DOI http://dx.doi.org/10.2147/BCTT.S17108

Published 29 March 2011

This paper has been retracted.
 
Rajeev Singhai1, Amit V Patil2, Vinayak W Patil1
1
Department of Biochemistry, Grant Medical College and Sir J J Group of Hospitals, Mumbai, India; 2Department of General Surgery, Government Medical College, Miraj, Maharashtra, India

Aim and objectives: In Indian women with breast cancer, the HER-2/neu gene is amplified in 30% of cases. Elevated serum HER-2/neu levels have been shown to be associated with a poor clinical prognosis and decreased survival in early stage breast cancer patients, and testing for this may help to manage the disease. The present study was therefore to estimate serum HER-2/neu levels in breast cancer patients and associate these with other prognostic factors.
Materials and methods: Serum HER-2/neu levels were studied in 207 patients with breast cancer, 15 with benign breast diseases, (BBD) and 175 age-matched healthy controls. Patients' age, menopausal status, node, and estrogen receptor (ER) and progesterone receptor (PgR) status were compared with serum HER-2/neu levels.
Results: Serum HER-2/neu overexpression was associated with age, disease stage and positive nodal status but not with menopausal status. Serum HER-2/neu levels were negatively correlated with hormone receptor positivity.
Conclusion: HER-2/neu serum tests should be done more frequently in Indian women with breast cancer, irrespective of their ER and PgR hormone receptor status. ELISA is a reliable and economical tool to assess the HER-2/neu status in tumors, when breast tissue samples are not available.

Keywords: breast cancer, serum HER-2/neu receptor assay, hormone receptor, ER, PgR

Download Article [PDF] View Full Text [HTML] 

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php

Other articles by this author:

The p53 breast cancer tissue biomarker in Indian women

Patil V, Tayade M, Pingale S, Dalvi S, Rajekar R, Deshmukh H, Patil S, Singhai R

Breast Cancer: Targets and Therapy 2011, 3:71-78

Published Date: 11 August 2011

Estrogen receptor (ER) and progesterone receptor (PgR) in breast cancer of Indian women

Patil AV, Bhamre RS, Singhai R, Tayade MB, Patil VW

Breast Cancer: Targets and Therapy 2011, 3:27-33

Published Date: 19 April 2011

Triple-negative (ER, PgR, HER-2/neu) breast cancer in Indian women

Vinayak W Patil, Rajeev Singhai, Amit V Patil, et al

Breast Cancer: Targets and Therapy 2011, 3:9-19

Published Date: 16 March 2011

Readers of this article also read:

MicroRNA-153 acts as a prognostic marker in gastric cancer and its role in cell migration and invasion

Zhang Z, Sun J, Bai Z, Li H, He S, Chen R, Che X

OncoTargets and Therapy 2015, 8:357-364

Published Date: 2 February 2015

Stem cell therapies for age-related macular degeneration: the past, present, and future

Dang Y, Zhang C, Zhu Y

Clinical Interventions in Aging 2015, 10:255-264

Published Date: 14 January 2015

Causal diagrams and the logic of matched case-control studies [Corrigendum]

Shahar E, Shahar DJ

Clinical Epidemiology 2014, 6:59-60

Published Date: 22 January 2014

Is higher body temperature beneficial in ischemic stroke patients with normal admission CT angiography of the cerebral arteries?

Kvistad CE, Khanevski A, Nacu A, Thomassen L, Waje-Andreassen U, Naess H

Vascular Health and Risk Management 2014, 10:49-54

Published Date: 21 January 2014

The p53 breast cancer tissue biomarker in Indian women

Patil V, Tayade M, Pingale S, Dalvi S, Rajekar R, Deshmukh H, Patil S, Singhai R

Breast Cancer: Targets and Therapy 2011, 3:71-78

Published Date: 11 August 2011

Corrigendum: Softec HD hydrophilic acrylic intraocular lens: biocompatibility and precision

Espandar L, Sikder S, Moshirfar M

Clinical Ophthalmology 2011, 5:159-160

Published Date: 6 February 2011