Back to Browse Journals » Journal of Blood Medicine » Volume 4

Biomarkers for the differentiation of anemia and their clinical usefulness

Authors Northrop-Clewes CA, Thurnham DI

Published Date March 2013 Volume 2013:4 Pages 11—22


Received 17 October 2012, Accepted 13 December 2012, Published 20 March 2013

Christine A Northrop-Clewes,1 David I Thurnham2

1Nutrition Consultant, Cambridge, UK; 2Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, Coleraine, UK

Abstract: The World Health Organization defines anemia as the point at which the amount of hemoglobin in the circulation falls below World Health Organization cutoffs for specific age and sex groups. Anemia is a worldwide problem of complex etiology and is associated with many factors. The purpose of this review was to describe the biomarkers used to identify the nature of anemia in patients and in the community. The important biomarkers are the automated red cell counts, tests for nutritional deficiencies, hemoglobinopathies, and inflammation. Diseases are important potential initiators of anemia, but biomarkers of specific diseases are not included in this review, only the underlying feature common to all disease – namely, inflammation.

Keywords: iron deficiency, biological markers, blood cell count, inflammation, avitaminosis, hemoglobinopathies

Download Article [PDF] View Full Text [HTML] 

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at:

Readers of this article also read:

Serum ferritin levels in adults with sickle cell disease in Lagos, Nigeria

Akinbami AA, Dosunmu AO, Adediran AA, Oshinaike OO, Osunkalu VO, Ajibola SO, Arogundade OM

Journal of Blood Medicine 2013, 4:59-63

Published Date: 22 May 2013

Lipid profile of regular blood donors

Uche EI, Adediran A, Damulak OD, Adeyemo TA, Akinbami AA, Akanmu AS

Journal of Blood Medicine 2013, 4:39-42

Published Date: 10 May 2013

Beta-amyloidolysis and glutathione in Alzheimer's disease

Lasierra-Cirujeda J, Coronel P, Aza MJ, Gimeno M

Journal of Blood Medicine 2013, 4:31-38

Published Date: 15 April 2013

Randomized double blind trial of ciprofloxacin prophylaxis during induction treatment in childhood acute lymphoblastic leukemia in the WK-ALL protocol in Indonesia

Widjajanto PH, Sumadiono S, Cloos J, Purwanto I, Sutaryo S, Veerman AJP

Journal of Blood Medicine 2013, 4:1-9

Published Date: 1 February 2013

First-line treatment of chronic myeloid leukemia with nilotinib: critical evaluation

Piccaluga PP, Paolini S, Bertuzzi C, De Leo A, Rosti G

Journal of Blood Medicine 2012, 3:151-156

Published Date: 29 November 2012

Optimal management of pernicious anemia

Andres E, Serraj K

Journal of Blood Medicine 2012, 3:97-103

Published Date: 10 September 2012