Bone regeneration: molecular and cellular interactions with calcium phosphate ceramics

Florence Barrère, Clemens A van Blitterswijk, Klaas de Groot Biomedical Technological institute (BMTi), University of Twente, Enschede, The Netherlands

Abstract: Calcium phosphate bioceramics are widely used in orthopedic and dental applications and porous scaffolds made of them are serious candidates in the field of bone tissue engineering. They have superior properties for the stimulation of bone formation and bone bonding, both related to the specific interactions of their surface with the extracellular fluids and cells, ie, ionic exchanges, superficial molecular rearrangement and cellular activity.  

Keywords: calcium phosphate, biomaterials, tissue engineering, osteoprogenitor cells, osteoconduction, osteoinduction