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Crizotinib as a personalized alternative for targeted anaplastic lymphoma kinase rearrangement in previously treated patients with non-small-cell lung cancer

Authors Guo L, Zhang H, Shao W, Chen B

Received 8 July 2015

Accepted for publication 14 September 2015

Published 3 October 2015 Volume 2015:9 Pages 5491—5497

DOI https://doi.org/10.2147/DDDT.S91988

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Wei Duan


Liting Guo,1,* Haijun Zhang,1,* Weiwei Shao,2 Baoan Chen1

1Department of Hematology and Oncology (Key Department of Jiangsu Medicine), The Affiliated Zhongda Hospital, Medical School of Southeast University, Nanjing, 2Department of Pathology, the First People’s Hospital of Yancheng, Yancheng, Jiangsu, People’s Republic of China

*These authors contributed equally to this work

Abstract: Crizotinib, the first clinically designed and synthesized as a tyrosine kinase inhibitor targeting mesenchymal–epithelial transition factor, indicating marked anticancer activity in patients with advanced, anaplastic lymphoma kinase-positive non-small-cell lung cancer, was approved by the US Food and Drug Administration in 2011. In this review, we focus on the efficacy of crizotinib compared with chemotherapy in advanced anaplastic lymphoma kinase-positive lung cancer and present the role of crizotinib as a personalized alternative in previously treated patients with non-small-cell lung cancer.

Keywords: crizotinib, anaplastic lymphoma kinase rearrangement, non-small-cell lung cancer
 

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