Back to Browse Journals » Journal of Inflammation Research » Volume 4

Vascular involvement in systemic sclerosis (scleroderma)

Authors Pattanaik D, Brown M, Postlethwaite AE

Published Date July 2011 Volume 2011:4 Pages 105—125


Published 26 July 2011

Debendra Pattanaik1, Monica Brown2, Arnold E Postlethwaite1
1Division of Connective Tissue Diseases, Department of Medicine; 2Section of Pediatric Rheumatology Department of Pediatrics, University of Tennessee Health Science Center, and Department of Veterans Affairs Medical Center, Memphis, TN, USA

Abstract: Systemic sclerosis (SSc) is an acquired multiorgan connective tissue disease with variable mortality and morbidity dictated by clinical subset type. The etiology of the basic disease and pathogenesis of the systemic autoimmunity, fibrosis, and fibroproliferative vasculopathy are unknown and debated. In this review, the spectrum of vascular abnormalities and the options currently available to treat the vascular manifestations of SSc are discussed. Also discussed is how the hallmark pathologies (ie, how autoimmunity, vasculopathy, and fibrosis of the disease) might be effected and interconnected with modulatory input from lysophospholipids, sphingosine 1-phosphate, and lysophosphatidic acid.

Keywords: fibrosis, autoimmunity, vasculopathy, S1P, LPA

Download Article [PDF] View Full Text [HTML] 

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at:

Readers of this article also read:

Knockout of the c-Jun N-terminal Kinase 2 aggravates the development of mild chronic dextran sulfate sodium colitis independently of expression of intestinal cytokines TNFα, TGFB1, and IL-6

Kersting S, Reinecke K, Hilgert C, Janot MS, Haarmann E, Albrecht M, Müller AM, Herdegen T, Mittelkötter U, Uhl W, Chromik AM

Journal of Inflammation Research 2013, 6:13-23

Published Date: 12 February 2013

Anemia associated with chronic heart failure: current concepts

Shah R, Agarwal AK

Clinical Interventions in Aging 2013, 8:111-122

Published Date: 4 February 2013

Case of invasive nontypable Haemophilus influenzae respiratory tract infection with a large quantity of neutrophil extracellular traps in sputum

Hamaguchi S, Seki M, Yamamoto N, Hirose T, Matsumoto N, Irisawa T, Takegawa R, Shimazu T, Tomono K

Journal of Inflammation Research 2012, 5:137-140

Published Date: 18 December 2012

Morphine treatment alters nucleotidase activities in rat blood serum

Rozisky JR, Nonose Y, Laste G, dos Santos VS, de Macedo IC, Battastini AM, Caumo W, Torres IL

Journal of Experimental Pharmacology 2012, 4:187-193

Published Date: 17 December 2012

Alteration of complement hemolytic activity in different trauma and sepsis models

Ehrnthaller C, Amara U, Weckbach S, Kalbitz M, Huber-Lang M, Bahrami S

Journal of Inflammation Research 2012, 5:59-66

Published Date: 27 July 2012

The effect of smoking on the symptoms and progression of multiple sclerosis: a review

Afsaneh Shirani, Helen Tremlett

Journal of Inflammation Research 2010, 3:115-126

Published Date: 1 September 2010

Immune response profiles after caterpillar exposure: a case report

Tamar A Smith-Norowitz, Kevin B Norowitz, Stephan Kohlhoff, et al

Journal of Inflammation Research 2010, 3:45-51

Published Date: 16 July 2010

Rheumatoid arthritis: Disease or syndrome?

Jessica A Stanich, John D Carter, Judith Whittum-Hudson, et al

Open Access Rheumatology: Research and Reviews 2009, 1:179-192

Published Date: 9 December 2009

Role of aliskiren in cardio-renal protection and use in hypertensives with multiple risk factors

Eduardo Pimenta, Suzanne Oparil

Vascular Health and Risk Management 2009, 5:453-463

Published Date: 19 May 2009