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Vaginal rings for delivery of HIV microbicides

Authors Malcolm RK, Fetherston SM, McCoy CF, Boyd P, Major I

Published Date November 2012 Volume 2012:4 Pages 595—605

DOI http://dx.doi.org/10.2147/IJWH.S36282

Received 31 August 2012, Accepted 16 October 2012, Published 20 November 2012

R Karl Malcolm, Susan M Fetherston, Clare F McCoy, Peter Boyd, Ian Major

School of Pharmacy, Queen's University Belfast, Belfast, UK

Abstract: Following the successful development of long-acting steroid-releasing vaginal ring devices for the treatment of menopausal symptoms and contraception, there is now considerable interest in applying similar devices to the controlled release of microbicides against HIV. In this review article, the vaginal ring concept is first considered within the wider context of the early advances in controlled-release technology, before describing the various types of ring device available today. The remainder of the article highlights the key developments in HIV microbicide-releasing vaginal rings, with a particular focus on the dapivirine ring that is presently in late-stage clinical testing.

Keywords: controlled release, sustained release, antiretroviral, dapivirine, SILCS diaphragm, silicone elastomer, thermoplastic

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