Back to Browse Journals » Vascular Health and Risk Management » Volume 8

The prevention and regression of atherosclerotic plaques: emerging treatments

Authors Kalanuria AA, Nyquist P, Ling G

Published Date September 2012 Volume 2012:8 Pages 549—561

DOI http://dx.doi.org/10.2147/VHRM.S27764

Received 7 May 2012, Accepted 2 July 2012, Published 25 September 2012

Atul Ashok Kalanuria,1 Paul Nyquist,1 Geoffrey Ling1,2

1Division of Neuro Critical Care, Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, 2Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA

Abstract: Occlusive vascular diseases, such as sudden coronary syndromes, stroke, and peripheral arterial disease, are a huge burden on the health care systems of developed and developing countries. Tremendous advances have been made over the last few decades in the diagnosis and treatment of atherosclerotic diseases. Intravascular ultrasound has been able to provide detailed information of plaque anatomy and has been used in several studies to assess outcomes. The presence of atherosclerosis disrupts the normal protective mechanism provided by the endothelium and this mechanism has been implicated in the pathophysiology of coronary artery disease and stroke. Efforts are being put into the prevention of atherosclerosis, which has been shown to begin in childhood. This paper reviews the pathophysiology of atherosclerosis and discusses the current options available for the prevention and reversal of plaque formation.

Keywords: cardiovascular, atherosclerotic disease, endothelium, plaque, reversal, coronary artery disease, stroke

Download Article [PDF] View Full Text [HTML] 

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php

Readers of this article also read:

Lower extremity amputation in peripheral artery disease: improving patient outcomes

Swaminathan A, Vemulapalli S, Patel MR, Jones WS

Vascular Health and Risk Management 2014, 10:417-424

Published Date: 16 July 2014

Effects of Arthro-7® in relieving symptoms of osteoarthritis with mild to moderate arthralgia [Corrigendum]

Xie Q, Zhou T, Yen L, Shariff M, Nguyen T, Kami K, Gu P, Liang L, Rao J, Shi R

Nutrition and Dietary Supplements 2013, 5:7-8

Published Date: 16 May 2013

Highly biocompatible, nanocrystalline hydroxyapatite synthesized in a solvothermal process driven by high energy density microwave radiation

Smolen D, Chudoba T, Malka I, Kedzierska A, Lojkowski W, Swieszkowski W, Kurzydlowski KJ, Kolodziejczyk-Mierzynska M, Lewandowska-Szumiel M

International Journal of Nanomedicine 2013, 8:653-668

Published Date: 12 February 2013

Atrial fibrillation and thromboprophylaxis in heart failure: the need for patient-centered approaches to address adherence

Ferguson C, Inglis SC, Newton PJ, Middleton S, Macdonald PS, Davidson PM

Vascular Health and Risk Management 2013, 9:3-11

Published Date: 17 January 2013

Bimatoprost ophthalmic solution 0.03% lowered intraocular pressure of normal-tension glaucoma with minimal adverse events. [Corrigendum]

Tsumura T, Yoshikawa K, Suzumura H, Kimura T, Sasaki S, Kimura I, Takeda R

Clinical Ophthalmology 2013, 7:129-130

Published Date: 16 January 2013

Topical azithromycin or ofloxacin for endophthalmitis

Stewart MW, Stewart ML

Clinical Ophthalmology 2013, 7:35-38

Published Date: 31 December 2012

Quality of life in patients treated by organ preservation surgery for early laryngeal carcinoma

Allegra E, Franco T, Trapasso S, Aragona T, Domanico R, Garozzo A

Open Access Surgery 2012, 5:27-32

Published Date: 15 October 2012

An MRI-visible non-viral vector for targeted Bcl-2 siRNA delivery to neuroblastoma

Shen M, Gong FM, Pang PF, Zhu KS, Meng XC, Wu C, Wang J, Shan H, Shuai XT

International Journal of Nanomedicine 2012, 7:3319-3332

Published Date: 2 July 2012

HbA1c is associated with severity of obstructive sleep apnea hypopnea syndrome in nondiabetic men

Nikolaos Papanas, Paschalis Steiropoulos, Evangelia Nena, et al

Vascular Health and Risk Management 2009, 5:751-756

Published Date: 8 September 2009