skip to content
Dovepress - Open Access to Scientific and Medical Research
View our mobile site

8852

Tachykinins and neurokinin receptors in bone marrow functions: neural-hematopoietic link

Review

(2724) Views  (703) Full article downloads

Authors: Tilman E Klassert, Shyam A Patel, Pranela Rameshwar

Published Date April 2010 Volume 2010:3 Pages 51 - 61
DOI: http://dx.doi.org/10.2147/JRLCR.S6509

Tilman E Klassert1,2, Shyam A Patel1,3, Pranela Rameshwar1

1Department of Medicine – Division of Hematology/Oncology, New Jersey Medical School, 3Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA; 2Instituto de Enfermedades Tropicales y Salud Pública, University of La Laguna, Canary Islands, Spain

Abstract: After many decades of neuropeptide research, advances in the field of tachykinins have considerably increased and revealed their implications in several physiological processes. In this review we focus on the role of the tachykinins in the regulation of hematopoietic functions. Evidence has shown that neural control of this process is emerging as a significant category in hematopoietic modulation. In the context of this regulation, we discuss the existence of a complex network involving the neurokinin receptors, tachykinins and cytokines. This network is tightly regulated by each of its components.

Keywords: hematopoiesis, tachykinins, neurokinin receptor, crosstalk, regulation






 

Other articles by Professor Pranela Rameshwar



Readers of this article also read:

Radiolucency below the crown of mandibular horizontal incompletely impacted third molars and acute inflammation in men with diabetes
Berberine: metabolic and cardiovascular effects in preclinical and clinical trials
Potential renovascular hypertension, space missions, and the role of magnesium
Critical appraisal of the role of glucosamine and chondroitin in the management of osteoarthritis of the knee
Ego mechanisms of defense are associated with patients’ preference of treatment modality independent of psychological distress in end-stage renal disease
Can a gentamicin-specific chart reduce neonatal medication errors?
Nephroprotective action of glycosaminoglycans: why the pharmacological properties of sulodexide might be reconsidered
Dashboards in neonatology
Everolimus-eluting stents: update on current clinical studies
Radio electric asymmetric brain stimulation in the treatment of behavioral and psychiatric symptoms in Alzheimer disease