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Profile of ipilimumab and its role in the treatment of metastatic melanoma

Authors Patel SP, Woodman SE

Published Date December 2011 Volume 2011:5 Pages 489—495

DOI http://dx.doi.org/10.2147/DDDT.S10945

Published 16 December 2011

Sapna P Patel, Scott E Woodman
Melanoma Medical Oncology Department, University of Texas, MD Anderson Cancer Center, Houston, TX, USA

Abstract: Melanoma is an immunogenic cancer. However, the ability of the immune system to eradicate melanoma tumors is affected by intrinsic negative regulatory mechanisms. Multiple immune-modulatory therapies are currently being developed to optimize the immune response to melanoma tumors. Two recent Phase III studies using the monoclonal antibody ipilimumab, which targets the cytotoxic T-lymphocyte antigen (CTLA-4), a negative regulator of T-cell activation, have demonstrated improvement in overall survival of metastatic melanoma patients. This review highlights the clinical trial data that supports the efficacy of ipilimumab, the immune-related response criteria used to evaluate clinical response, and side-effect profile associated with ipilimumab treatment.

Keywords: ipilimumab, melanoma, T-cells, CTLA-4

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