skip to content
Dovepress - Open Access to Scientific and Medical Research
View our mobile site

15319

Prevalence and risk factors associated with peripheral artery disease in elderly patients undergoing peritoneal dialysis



Original Research

(2389) Total Article Views


Authors: Kuang DW, Li CL, Kuok UI, Cheung K, Lio WI, Xin J

Published Date October 2012 Volume 2012:8 Pages 581 - 586
DOI: http://dx.doi.org/10.2147/VHRM.S37008

Ding-Wei Kuang,1,2,* Chiu-Leong Li,1,* Un-I Kuok,1 Kin Cheung,1 Weng-In Lio,1 Jing Xin1,2

1
Department of Nephrology, Centro Hospitalar Conde de São Januário, Macao, China; 2Department of Nephrology, Huashan Hospital, Shanghai, China

*These authors contributed equally to this work

Background: Rapid growth of the elderly peritoneal dialysis (PD) population is posing a special challenge for renal teams. Peripheral artery disease (PAD) has been reported to be an independent predictor of cardiovascular and all-cause mortality in hemodialysis patients. However, the prevalence and associated risk factors for PAD in elderly PD patients have not yet been fully investigated.
Methods: A total of 69 elderly PD patients were included in the present study. PAD was defined as either an ankle-brachial index < 0.9 or a history of intermittent claudication, lower-limb amputation, foot ulcers, or gangrene. On enrollment, clinical and biochemical characteristics were collected.
Results: The overall prevalence of PAD was 31.9%. Compared with non-PAD patients, PAD patients were significantly older and more likely to be female and have longer PD duration and lower diastolic blood pressure (P < 0.001, = 0.002, 0.018, and 0.007, respectively). Serum albumin level (P < 0.001) and residual renal Kt/V value (P < 0.001) were significantly lower, but the serum C-reactive protein level (P = 0.005) was significantly higher, in PAD patients compared with non-PAD patients. Logistic regression analysis showed that serum albumin level (odds ratio = 1.485, P = 0.040) and residual renal Kt/V value (odds ratio = 1.725, P = 0.016) were independently associated with PAD.
Conclusion: A high prevalence of PAD appeared among elderly PD patients in Macao. Serum albumin level and residual renal Kt/V value were independently related to PAD.

Keywords: ankle-brachial index, atherosclerosis, elderly, peripheral artery disease, peritoneal dialysis




Post to:
Cannotea Citeulike Del.icio.us Facebook LinkedIn Twitter


Readers of this article also read: