Potential clinical applications of quantum dots

Review

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Authors: Igor L Medintz, Hedi Mattoussi, Aaron R Clapp

Published Date June 2008 Volume 2008:3(2) Pages 151 - 167

DOI: http://dx.doi.org/10.2147/IJN.S614

Igor L Medintz¹, Hedi Mattoussi², Aaron R Clapp³

¹Center for Bio/Molecular Science and Engineering, Code 6900, US Naval Research Laboratory, Washington, DC, USA; ²Optical Sciences Division, Code 5611, US Naval Research Laboratory, Washington, DC, USA; ³Department of Chemical and Biological Engineering, Iowa State University, Ames, IA, USA

Abstract: The use of luminescent colloidal quantum dots in biological investigations has increased dramatically over the past several years due to their unique size-dependent optical properties and recent advances in biofunctionalization. In this review, we describe the methods for generating high-quality nanocrystals and report on current and potential uses of these versatile materials. Numerous examples are provided in several key areas including cell labeling, biosensing, in vivo imaging, bimodal magnetic-luminescent imaging, and diagnostics. We also explore toxicity issues surrounding these materials and speculate about the future uses of quantum dots in a clinical setting.

Keywords: quantum dot, nanoparticle, biosensor, fluorescence, imaging, immunoassay, toxicity, FRET