skip to content
Dovepress - Open Access to Scientific and Medical Research
View our mobile site

8852

Less harmful acidic degradation of poly(lactic-co-glycolic acid) bone tissue engineering scaffolds through titania nanoparticle addition

(3007) Views  (796) Full article downloads

Authors: Huinan Liu, Elliott B Slamovich, Thomas J Webster

Published Date February 2006 Volume 2006:1(4) Pages 541 - 545
DOI: http://dx.doi.org/10.2147/IJN.S

Huinan Liu1, Elliott B Slamovich2, Thomas J Webster1
 

1Division of Engineering, 182 Hope Street, Brown University, Providence, RI 02912, USA; 2School of Materials Engineering, 501 Northwestern Avenue, Purdue University, West Lafayette, IN 47907, USA.

Abstract: In the last 10 years, biodegradable aliphatic polyesters, such as poly(lactic-co-glycolic acid) (PLGA), have attracted increasing attention for their use as scaffold materials in bone tissue engineering because their degradation products can be removed by natural metabolic pathways. However, one main concern with the use of these specific polymers is that their degradation products reduce local pH, which in turn induces an inflammatory reaction and damages bone cell health at the implant site. Thus, the objective of the present in vitro study was to investigate the degradation behavior of PLGA when added with dispersed titania nanoparticles. The results of this study provided the first evidence that the increased dispersion of nanophase titania in PLGA decreased the harmful change in pH normal for PLGA degradation. Moreover, previous studies have demonstrated that the increased dispersion of titania nanoparticles into PLGA significantly improved osteoblast (bone-forming cell) functions (such as adhesion, collagen synthesis, alkaline phosphatase activity, and calcium-containing minerals deposition). In this manner, nanophase titania–PLGA composites may be promising scaffold materials for more effective orthopedic tissue engineering applications.

Keywords: nanocomposites, tissue engineering scaffolds, polymer/ceramic composites, nanophase titania, degradation, poly(lactic-co-glycolic acid)








Readers of this article also read:

Basic fibroblast growth factor induces matrix metalloproteinase-13 via ERK MAP kinase-altered phosphorylation and sumoylation of Elk-1 in human adult articular chondrocytes
Role of cartilage-forming cells in regenerative medicine for cartilage repair
Articular cartilage repair and the evolving role of regenerative medicine
Endostar-loaded PEG-PLGA nanoparticles: in vitro and in vivo evaluation
Potential clinical applications of adult human mesenchymal stem cell (Prochymal®) therapy
Improved drug loading and antibacterial activity of minocycline-loaded PLGA nanoparticles prepared by solid/oil/water ion pairing method
The comparison of different daidzein-PLGA nanoparticles in increasing its oral bioavailability
Physiologically based pharmacokinetic modeling of PLGA nanoparticles with varied mPEG content
Preparation, characterization, and cytotoxicity of CPT/Fe2O3-embedded PLGA ultrafine composite fibers: a synergistic approach to develop promising anticancer material
Nanofibrous poly(lactide-co-glycolide) membranes loaded with diamond nanoparticles as promising substrates for bone tissue engineering