Back to Browse Journals » Cancer Management and Research » Volume 4

Inherited variation in pattern recognition receptors and cancer: dangerous liaisons?

Authors Kutikhin AG, Yuzhalin AE

Published Date February 2012 Volume 2012:4 Pages 31—38

DOI http://dx.doi.org/10.2147/CMAR.S28688

Received 30 November 2011, Accepted 28 December 2011, Published 16 February 2012

Anton G Kutikhin, Arseniy E Yuzhalin

Department of Epidemiology, Kemerovo State Medical Academy, Kemerovo, Russian Federation

Abstract: The group of pattern recognition receptors includes families of Toll-like receptors, NOD-like receptors, C-type lectin receptors, and RIG-I-like receptors. They are key sensors for a number of infectious agents, some of which are carcinogenic, and they launch an immune response against them. Inherited structural variation in genes encoding these receptors and proteins of their signaling pathways may affect their function, modulating cancer risk and features of cancer progression. Relevant malignancies, valuable gene polymorphisms, prime questions about future directions, and answers to these questions are analyzed in this review. It is possible to suggest that polymorphisms of genes encoding pattern recognition receptors and proteins of their signaling pathways may be associated with almost all cancer types, particularly with those in which carcinogenic infectious agents are responsible for the substantial share of cases (namely gastric cancer, colorectal cancer, liver cancer, cervical cancer, and nasopharyngeal carcinoma). The concept of selection of polymorphisms for further oncogenomic investigation, based on a combination of results from basic and epidemiological studies, is proposed.

Keywords:
pattern recognition receptors, Toll-like receptors, NOD-like receptors, C-type lectin receptors, cancer, gene polymorphisms

Download Article [PDF] View Full Text [HTML] 

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php

Other articles by this author:

The role of calcifying nanoparticles in biology and medicine

Kutikhin AG, Brusina EB, Yuzhalin AE

International Journal of Nanomedicine 2012, 7:339-350

Published Date: 19 January 2012

C-type lectin receptors and RIG-I-like receptors: new points on the oncogenomics map

Kutikhin AG, Yuzhalin AE

Cancer Management and Research 2012, 4:39-53

Published Date: 24 February 2012

Readers of this article also read:

Preparation and characterization of gelatin sponge millispheres injectable through microcatheters

Noboru Yamashita, Katsumi Saitou, Akira Takagi, Atsushi Maruyama

Medical Devices: Evidence and Research 2009, 2:19-25

Published Date: 21 January 2009

Role of aliskiren in cardio-renal protection and use in hypertensives with multiple risk factors

Eduardo Pimenta, Suzanne Oparil

Vascular Health and Risk Management 2009, 5:453-463

Published Date: 19 May 2009

Ultrasonic synthetic technique to manufacture a pHEMA nanopolymeric-based vaccine against the H6N2 avian influenza virus: a preliminary investigation

Poinern GEJ, Thi Le X, Shan S, Ellis T, Fenwick S, Edwards J, Fawcett D

International Journal of Nanomedicine 2011, 6:2167-2174

Published Date: 28 September 2011

C-type lectin receptors and RIG-I-like receptors: new points on the oncogenomics map

Kutikhin AG, Yuzhalin AE

Cancer Management and Research 2012, 4:39-53

Published Date: 24 February 2012

Critical appraisal of the use of regorafenib in the management of colorectal cancer

Festino L, Fabozzi A, Manzo A, Gambardella V, Martinelli E, Troiani T, De Vita F, Orditura M, Ciardiello F, Morgillo F

Cancer Management and Research 2013, 5:49-55

Published Date: 12 April 2013

Advanced medullary thyroid cancer: pathophysiology and management

Ferreira CV, Siqueira DR, Ceolin L, Maia AL

Cancer Management and Research 2013, 5:57-66

Published Date: 8 May 2013

Clinical outcome of incidentally discovered small renal cell carcinoma after delayed surgery

Sugimoto K, Shimizu N, Oki T, Nose K, Nishioka T, Adomi S, Ohzeki T, Esa A, Uemura H

Cancer Management and Research 2013, 5:85-89

Published Date: 24 May 2013