skip to content
Dovepress - Open Access to Scientific and Medical Research
View our mobile site

8852

Importance of solid lipid nanoparticles (SLN) in various administration routes and future perspectives

(3227) Views  (3062) Full article downloads

Authors: Melike Üner, Gülgün Yener

Published Date October 2007 Volume 2007:2(3) Pages 289 - 300
DOI: http://dx.doi.org/10.2147/IJN.S

Melike Üner, Gülgün Yener

Istanbul University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Beyazit 34119 Istanbul, Turkey

Abstract: Solid lipid nanoparticles (SLN) have been reported to be an alternative system to emulsions, liposomes, microparticles and their polymeric counterparts for various application routes since the early 1990s due to their advantages. Various research groups have also increasingly focused on improving their stability in body fluids after administration by coating of particles with hydrophilic molecules such as poly(ethylene)glycol (PEG) derivatives. Altering surface characteristics by coating SLN with hydrophilic molecules improves plasma stability and biodistribution, and subsequent bioavailability of drugs entrapped. Their storage stability is also increased. This paper basicly reviews types of SLN, principles of drug loading and models of drug incorporation. The influence of PEG coating on particle size and surface characteristics is discussed followed by alteration in pharmacokinetics and bioavailability of drugs in order to target the site of action via SLN. The future direction of research and clinical implications of SLN is also considered.

Keywords: solid lipid nanoparticles, nanostructured lipid carriers, drug incorporation models, particle size, surface characteristics, PEG coating, drug release








Readers of this article also read:

Enhanced endothelial cell density on NiTi surfaces with sub-micron to nanometer roughness
Evidence-based decision-making within the context of globalization: A “Why–What–How” for leaders and managers of health care organizations
Radiolucency below the crown of mandibular horizontal incompletely impacted third molars and acute inflammation in men with diabetes
Exacerbation rate, health status and mortality in COPD – a review of potential interventions
The pathophysiology of bronchiectasis
Biomimetic nanoparticles: preparation, characterization and biomedical applications
Amino acid management of Parkinson’s disease: a case study
Evaluation of in-vitro antibiotic susceptibility of different morphological forms of Borrelia burgdorferi
Long-term treatment of bipolar disorder with a radioelectric asymmetric conveyor
Elucidation mechanism of different biological responses to multi-walled carbon nanotubes using four cell lines