Back to Browse Journals » Open Access Surgery » Volume 1

Gamma knife radiosurgery for uveal melanoma ineligible for brachytherapy by the Collaborative Ocular Melanoma Study criteria

Authors Nicola G Ghazi, Christopher S Ketcherside, Jason Sheehan, Brian P Conway

Published Date September 2008 Volume 2008:1 Pages 21—24

DOI http://dx.doi.org/10.2147/OAS.S3654

Published 30 September 2008

Nicola G Ghazi1, Christopher S Ketcherside1, Jason Sheehan2, Brian P Conway1

1Department of Ophthalmology and 2Neurosurgery, University of Virginia Health System, Charlottesville, VA, USA

Purpose: To report outcomes of Gamma Knife radiosurgery (GKRS) in treating uveal melanoma lesions ineligible for standard brachytherapy.

Methods: A retrospective interventional case series of uveal melanoma patients treated with GKRS between 1996 and 2004 was performed. The main outcome measures were local tumor control, metastasis, and death.

Results: Four patients with uveal melanoma treated with GKS were identified. Three tumors involved the ciliary body and one was macular with its border within 2 mm of the optic disc. Adequate globe stabilization was achieved by retrobulbar anesthesia in all cases. Pretreatment mean visual acuity was 20/30. Tumor volume as determined by magnetic resonance imaging ranged from 0.05 to 0.30 cc. Ultrasonographic greatest tumor diameter and height ranged from 11 to 18 mm (mean 14.5 mm) and 2.9 to 4.5 mm (mean 3.6 mm), respectively. The peripheral dose varied from 16.5 to 30 Gray. Local tumor control was achieved in all cases over a follow up period of 6 to 96 months. Mean final visual acuity was 20/50. One eye was enucleated for neovascular glaucoma and one patient died from liver and lung metastasis.

Conclusions: GKRS for uveal melanoma appears to be safe and effective. The metastasis and mortality rates appear to be comparable to those following brachytherapy and enucleation. Moreover, local tumor control and enucleation rates are similar to those following brachytherapy. The findings in this small series suggest a role for GKRS in the treatment of selected cases of uveal melanomas.

Keywords: gamma knife radiosurgery, radiation therapy, uveal melanoma

Download Article [PDF] 

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php

Other article by this author:

Is reduction in the risk of vision loss the only benefit of photodynamic therapy in predominantly classic subfoveal choroidal neovascularization?

Nicola G Ghazi, Brian P Conway, James S Tiedeman, Steven J Yoon

Clinical Ophthalmology 2008, 2:773-780

Published Date: 18 September 2008

Readers of this article also read:

Validation of the Memorial Sloan Kettering Cancer Center nomogram for predicting non-sentinel lymph node metastasis in sentinel lymph node-positive breast-cancer patients

Bi X, Wang Y, Li M, Chen P, Zhou Z, Liu Y, Zhao T, Zhang Z, Wang C, Sun X, Qiu P

OncoTargets and Therapy 2015, 8:487-493

Published Date: 23 February 2015

Experience of insomnia, symptom attribution and treatment preferences in individuals with moderate to severe COPD: a qualitative study

Kauffman KS, Doede M, Diaz-Abad M, Scharf SM, Bell-Farrell W, Rogers VE, Geiger-Brown J

Patient Preference and Adherence 2014, 8:1699-1704

Published Date: 10 December 2014

Enhancement of radiotherapy efficacy by miR-200c-loaded gelatinase-stimuli PEG-Pep-PCL nanoparticles in gastric cancer cells

Cui FB, Liu Q, Li RT, Shen J, Wu PY, Yu LX, Hu WJ, Wu FL, Jiang CP, Yue GF, Qian XP, Jiang XQ, Liu BR

International Journal of Nanomedicine 2014, 9:2345-2358

Published Date: 13 May 2014

Efficacy of the anti-VZV (anti-HSV3) vaccine in HSV1 and HSV2 recurrent herpes simplex disease: a prospective study

Le Goaster J, Gonzalo S, Bouree P, Tangy F, Haenni AL

Open Access Journal of Clinical Trials 2012, 4:51-58

Published Date: 30 July 2012

Excessive visceral fat accumulation in advanced chronic obstructive pulmonary disease

Furutate R, Ishii T, Wakabayashi R, Motegi T, Yamada K, Gemma A, Kida K

International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:423-430

Published Date: 8 August 2011

The western diet and lifestyle and diseases of civilization

Pedro Carrera-Bastos, Maelan Fontes-Villalba, James H O’Keefe, et al

Research Reports in Clinical Cardiology 2011, 2:15-35

Published Date: 9 March 2011

Alogliptin: a new addition to the class of DPP-4 inhibitors

Radha Andukuri, Andjela Drincic, Marc Rendell

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2009, 2:117-126

Published Date: 21 July 2009

Exacerbation rate, health status and mortality in COPD – a review of potential interventions

Terence AR Seemungal, John R Hurst, Jadwiga A Wedzicha

International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:203-223

Published Date: 29 May 2009

Eggshell membrane: A possible new natural therapeutic for joint and connective tissue disorders. Results from two open-label human clinical studies

Kevin J Ruff, Dale P DeVore, Michael D Leu, Mark A Robinson

Clinical Interventions in Aging 2009, 4:235-240

Published Date: 18 May 2009