skip to content
Dovepress - Open Access to Scientific and Medical Research
View our mobile site

8852

Firstborn microcrystallization method to prepare nanocapsules containing artesunate

Rapid Communication

(3155) Views  (623) Full article downloads

Authors: Xin-Cai Xiao, Zong-Guo Hong

Published Date July 2010 Volume 2010:5 Pages 483 - 486
DOI: http://dx.doi.org/10.2147/IJN.S10907

Xin-Cai Xiao, Zong-Guo Hong

School of Pharmacy, South-Central University for Nationalities, Wuhan, 430074, China

Abstract: We developed a novel method to prepare nanocapsules. A solute often crystallizes when its solubility alters from one solvent to another, and its firstborn crystals are used as templates to prepare nanocapsules for the first time, which is called firstborn microcrystallization method. By using this method, the maximum diameter of the nanocapsules including artesunate is about 76 nm, and wrapping state is well. One important advantage of our method is that the preparation of the nanocapsules operates easily and is a one-time process with no other cumbersome processes necessary, therefore avoiding secondary pollution. The proposed method provides a new route to prepare monodisperse nanocapsules to increase bioavailability of hydrophobic solutes.

Keywords: firstborn microcrystallization method, nanocapsules, artesunate






Readers of this article also read:

Evidence-based decision-making within the context of globalization: A “Why–What–How” for leaders and managers of health care organizations
Periosteoplasty for covering gingival recessions: Clinical results
Radiolucency below the crown of mandibular horizontal incompletely impacted third molars and acute inflammation in men with diabetes
"Globalized public health.” A transdisciplinary comprehensive framework for analyzing contemporary globalization’s influences on the field of public health
Toxic effects of iron oxide nanoparticles on human umbilical vein endothelial cells
Release profile and stability evaluation of optimized chitosan/alginate nanoparticles as EGFR antisense vector
Preparation and in vitro characterization of 9-nitrocamptothecin-loaded long circulating nanoparticles for delivery in cancer patients
Topical piroxicam in vitro release and in vivo anti-inflammatory and analgesic effects from palm oil esters-based nanocream
Comparison of two treatments for coxarthrosis: local hyperthermia versus radio electric asymmetrical brain stimulation
Radio electric asymmetric brain stimulation in the treatment of behavioral and psychiatric symptoms in Alzheimer disease