Back to Browse Journals » Pathology and Laboratory Medicine International » Volume 3

Fibrous dysplasia of bone: a clinicopathologic review

Authors Mohan H, Mittal P, Mundi I, Kumar S

Published Date November 2011 Volume 2011:3 Pages 31—42

DOI http://dx.doi.org/10.2147/PLMI.S24866

Published 8 November 2011

Harsh Mohan1, Preeti Mittal1, Irneet Mundi1, Sudhir Kumar2
1Department of Pathology, 2Department of Orthopedics, Government Medical College, Sector 32, Chandigarh, India

Abstract: Fibrous dysplasia of the bones is an uncommon congenital skeletal disorder that is found equally in both genders and is not inherited. Its etiology has been linked to an activating mutation of Gsα and the downstream effects of the resultant increase in cAMP. Fibrous dysplasia is categorized as either monostotic or polyostotic, and may occur as a component of McCune-Albright syndrome or the rare Mazabraud syndrome. Long bones, skull bones, and ribs are the most commonly affected bones. The radiological picture is somewhat variable, including a ground-glass appearance, expansion of the bone, and sclerosis surrounding the lesion. Histologically, fibrous dysplasia shows irregularly-shaped trabeculae of immature, woven bone in a background of variably cellular, loosely arranged fibrous stroma. It may be complicated by pathologic fracture, and rarely by malignant transformation. This review examines interesting issues surrounding the etiology of fibrous dysplasia, its clinical and laboratory manifestations, radiological picture, utility of bone biopsy, gross and microscopic pathology, complications, and its differential diagnostic considerations.

Keywords: fibrous dysplasia, McCune-Albright syndrome, monostotic form, polyostotic form

Download Article [PDF] 

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php

Readers of this article also read:

External beam radiotherapy synergizes 188Re-liposome against human esophageal cancer xenograft and modulates 188Re-liposome pharmacokinetics

Chang CH, Liu SY, Chi CW, Yu HL, Chang TJ, Tsai TH, Lee TW, Chen YJ

International Journal of Nanomedicine 2015, 10:3641-3649

Published Date: 19 May 2015

Preparation and in vitro antitumor effects of cytosine arabinoside-loaded genipin-poly-L-glutamic acid-modified bacterial magnetosomes

Liu YG, Dai QL, Wang SB, Deng QJ, Wu WG, Chen AZ

International Journal of Nanomedicine 2015, 10:1387-1397

Published Date: 17 February 2015

BMP2-loaded hollow hydroxyapatite microspheres exhibit enhanced osteoinduction and osteogenicity in large bone defects

Xiong L, Zeng J, Yao A, Tu Q, Li J, Yan L, Tang Z

International Journal of Nanomedicine 2015, 10:517-526

Published Date: 12 January 2015

Effect of hemodialysis on visual acuity, intraocular pressure, and macular thickness in patients with chronic kidney disease

Chelala E, Dirani A, Fadlallah A, Slim E, Abdelmassih Y, Fakhoury H, Baz P, Bejjani R

Clinical Ophthalmology 2015, 9:109-114

Published Date: 9 January 2015

A pilot randomized controlled trial using EEG-based brain–computer interface training for a Chinese-speaking group of healthy elderly

Lee TS, Quek SY, Goh SJA, Phillips R, Guan C, Cheung YB, Feng L, Wang CC, Chin ZY, Zhang H, Lee J, Ng TP, Krishnan KRR

Clinical Interventions in Aging 2015, 10:217-227

Published Date: 9 January 2015

Therapeutic efficiency of folated poly(ethylene glycol)-chitosan-graft-polyethylenimine-Pdcd4 complexes in H-ras12V mice with liver cancer

Kim YK, Minai-Tehrani A, Lee JH, Cho CS, Cho MH, Jiang HL

International Journal of Nanomedicine 2013, 8:1489-1498

Published Date: 16 April 2013

In vitro evaluation of the effects of graphene platelets on glioblastoma multiforme cells

Jaworski S, Sawosz E, Grodzik M, Winnicka A, Prasek M, Wierzbicki M, Chwalibog A

International Journal of Nanomedicine 2013, 8:413-420

Published Date: 24 January 2013

Supramolecular micellar nanoaggregates based on a novel chitosan/vitamin E succinate copolymer for paclitaxel selective delivery

Lian H, Sun J, Yu YP, Liu YH, Cao W, Wang YJ, Sun YH, Wang SL, He ZG

International Journal of Nanomedicine 2011, 6:3323-3334

Published Date: 12 December 2011

Erratum

Utine CA

Clinical Ophthalmology 2011, 5:1415-1416

Published Date: 28 September 2011

Mirtogenol® potentiates latanoprost in lowering intraocular pressure and improves ocular blood flow in asymptomatic subjects

Robert D Steigerwalt Jr, Gianni Belcaro, Paolo Morazzoni, et al

Clinical Ophthalmology 2010, 4:471-476

Published Date: 12 May 2010