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Endophthalmitis: Pathogenesis, clinical presentation, management, and perspectives

Authors M Kernt, A Kampik

Published Date March 2010 Volume 2010:4 Pages 121—135

DOI http://dx.doi.org/10.2147/OPTH.S6461

Published 5 March 2010

M Kernt, A Kampik

Department of Ophthalmology, Ludwig Maximilian University, Munich, Germany

Abstract: Endophthalmitis is a rare but sight-threatening complication that can occur after ocular surgery or trauma or as a consequence of systemic infection. To optimize visual outcome, early diagnosis and treatment are essential. Over recent decades, advances in hygienic standards, improved microbiologic and surgical techniques, development of powerful antimicrobial drugs, and the introduction of intravitreal antibiotic therapy have led to a decreased incidence and improved management of endophthalmitis. However, endophthalmitis still represents a serious clinical problem. This review focuses on current principles and techniques for evaluation and treatment of endophthalmitis. In addition, it addresses recent developments regarding antimicrobial treatment and prophylaxis of infectious endophthalmitis.

Keywords: endophthalmitis, intravitreal, antibiotics, victrectomy, moxifloxacin, voriconazole, caspofungin

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