Back to Browse Journals » Nanotechnology, Science and Applications » Volume 3

Emerging use of nanostructure films containing capped gold nanoparticles in biosensors

Authors Jitendra Satija, Reshma Bharadwaj, VVR Sai, et al

Published Date December 2010 Volume 2010:3 Pages 171—188

DOI http://dx.doi.org/10.2147/NSA.S8981

Published 6 December 2010

Jitendra Satija1, Reshma Bharadwaj2, VVR Sai3, Soumyo Mukherji1,2,4
1Department of Bioscience and Bioengineering, IIT Bombay, Mumbai,Maharashtra, India; 2Centre of Excellence for Nanoelectronics, IIT Bombay, Mumbai, Maharashtra, India; 3Department of Chemistry, University of Idaho, Moscow, ID, USA; 4Centre for Research in Nanotechnology and Sciences, IIT Bombay, Mumbai, Maharashtra, India
Abstract: The localized surface plasmon resonance (LSPR) property of gold nanoparticles (GNP) has been exploited in a variety of optical sensor configurations including solution-based bioassays, paper-based colorimetric detection, surface-confined nanoparticle film/array-based sensing, etc. Amongst these, gold nanostructured films are of great interest because of their high stability, good reproducibility, robustness, and cost-effectiveness. The inherent optical characteristics of GNP, are attributed to parameters like size and shape (eg, nanospheres, nanorods, nanostars), eg, LSPR spectral location sensitivity to the local environment, composition (eg, gold–silver or silica–gold nanoshells), sensing volume, mesospacing, and multiplexing. These properties allow sensor tunability, enabling enhanced sensitivity and better performance of these biosensors. Ultrasensitive biosensor designs were realized using gold nanostructured films fabricated by bottom-up as well as top-down approaches. In this review, we describe the past, present, and future trends in the development of GNP-LSPRbased sensors, concentrating on both design (fabrication) and application. In the process, we have discussed various combinations of GNP size and shape, substrate, and application domains.
Keywords: localized surface plasmon resonance, gold nanoparticles, label-free optical biosensor

Download Article [PDF] 

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php

Readers of this article also read:

Applications of gold nanoparticles in cancer nanotechnology

Weibo Cai, Ting Gao, Hao Hong, Jiangtao Sun

Nanotechnology, Science and Applications 2008, 1:17-32

Published Date: 19 September 2008

Gold nanoparticles: From nanomedicine to nanosensing

Po C Chen, Sandra C Mwakwari, Adegboyega K Oyelere

Nanotechnology, Science and Applications 2008, 1:45-66

Published Date: 2 November 2008

Problems and barriers of pain management in the emergency department: Are we ever going to get better?

Sergey M Motov, Abu NGA Khan

Journal of Pain Research 2009, 2:5-11

Published Date: 9 December 2008

Health literacy and health seeking behavior among older men in a middle-income nation

Paul A Bourne, Chloe Morris, Christopher AD Charles, et al

Patient Related Outcome Measures 2010, 1:39-49

Published Date: 26 May 2010

Fluoroquinolone antibacterial eye drops: effects on normal human corneal epithelium, stroma, and endothelium

Ryou Watanabe, Toru Nakazawa, Shunji Yokokura, et al

Clinical Ophthalmology 2010, 4:1181-1187

Published Date: 7 October 2010

Neurotransmitter testing of the urine: a comprehensive analysis

Marty Hinz, Alvin Stein, George Trachte, et al

Research and Reports in Urology 2010, 2:177-183

Published Date: 7 October 2010

Preparation and characterization of microporous poly(D,L-lactic acid) film for tissue engineering scaffold

Shuai Shi, Xiu Hong Wang, Gang Guo, et al

International Journal of Nanomedicine 2010, 5:1049-1055

Published Date: 24 November 2010

Biosensors: the new wave in cancer diagnosis

Brian Bohunicky, Shaker A Mousa

Nanotechnology, Science and Applications 2011, 4:1-10

Published Date: 30 December 2010

Fungus-mediated biological synthesis of gold nanoparticles: potential in detection of liver cancer

Chauhan A, Zubair S, Tufail S, Sherwani A, Sajid M, Raman SC, Azam A, Owais M

International Journal of Nanomedicine 2011, 6:2305-2319

Published Date: 12 October 2011