Back to Browse Journals » Nutrition and Dietary Supplements » Volume 3

Efficacy of a novel, biologically active food supplement in type 2 diabetes mellitus: a patient-blinded, prospective, clinical trial

Authors Podichetty VK, Weshler M, Schlosser J

Published Date April 2011 Volume 2011:3 Pages 59—66

DOI http://dx.doi.org/10.2147/NDS.S18097

Published 11 April 2011

Vinod K Podichetty1, Mishel Weshler2, John Schlosser3
1
Research Practice Partners Inc., Miramar, Florida, USA; 2Weshler and Weshler Clinic, Nazareth Illit, Israel; 3Rockland Endocrine and Diabetic Services, Suffern, New York, USA

Abstract: Despite significant achievements in the prevention and management of diabetes, its prevalence has risen exponentially, creating a paramount need for alternative therapies. The purpose of the study was to investigate the safety and efficacy of two novel, biologically active supplements (fenugreek, fennel, sage, olive, and cinnamon and other ingredients) in decreasing blood glucose levels (BGLs) in type 2 diabetes mellitus (T2DM). Between June 2008 and July 2009, 154 patients were screened for T2DM and inadequate glycemic control. Fifty-one subjects meeting inclusion/exclusion criteria were enrolled in a prospective clinical study. All patients (n = 51) were studied for 24 weeks (6 months), the first 3 weeks being the placebo phase, followed by 14 weeks of active supplement use and observation for 3 weeks. Patients returned to active supplement use for an additional 3 weeks. All participants were tested for fasting BGL once every week during a 22-week period. The average age of the subjects was 52.6 years (23 male; 28 female), and average reference BGL (on day 1) was 265.7 mg/dL. During the first 3-week placebo period, patients showed no detectable change in BGL. At week 10 (after 7 weeks of supplement use), BGL was reduced by 47% compared with baseline (mean + standard deviation, day1 vs week 10, 265.7 + 86.2 vs 131.6 + 31.7; paired t-test = -11.8, P < 0.001), and at week 17, BGL decreased by 59% (P < 0.001). Between weeks 18 and 20, during which no participant received placebo or supplements, BGL did not decrease. The glucose-lowering effect of the supplement was stable and prolonged to maintain BGL at a constant level. Patients reported satisfaction on a Likert scale, and no side effects were reported during the course of the study. The current study indicates that the new biologically active dietary supplements were effective in decreasing BGL in T2DM patients with no side effects and has therapeutic promise in regulating BGL.

Keywords: blood glucose, cinnamon, fenugreek, glucose metabolism, olive, sage, type 2 diabetes mellitus

Download Article [PDF] 

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php

Readers of this article also read:

Effects of Arthro-7® in relieving symptoms of osteoarthritis with mild to moderate arthralgia

Xie Q, Zhou T, Yen L, Shariff M, Nguyen T, Kami K, Gu P, Liang L, Rao J, Shi R

Nutrition and Dietary Supplements 2013, 5:1-6

Published Date: 28 March 2013

High doses of vitamin A impair iron absorption

Gabriel FR, Suen VM, Marchini JS, Dutra de Oliveira JE

Nutrition and Dietary Supplements 2012, 4:61-65

Published Date: 1 October 2012

Dietary recommendations for patients with rheumatoid arthritis: a review

Vitetta L, Coulson S, Schloss J, Beck SL, Allen R, Sali A

Nutrition and Dietary Supplements 2012, 4:1-15

Published Date: 19 June 2012

Vitamin D deficiency in HIV-infected patients: a systematic review

Giusti A, Penco G, Pioli G

Nutrition and Dietary Supplements 2011, 3:101-111

Published Date: 29 November 2011

Role of n-3 series polyunsaturated fatty acids in cardiovascular disease prevention

Lee AH, Hiramatsu N

Nutrition and Dietary Supplements 2011, 3:93-100

Published Date: 15 September 2011

Use of dietary supplements among US adults with asthma

Jun Ma, Lan Xiao

Nutrition and Dietary Supplements 2011, 3:9-18

Published Date: 12 January 2011

The beneficial effects of spirulina focusing on its immunomodulatory and antioxidant properties

Maddaly Ravi, Sai Lata De, Syed Azharuddin, et al

Nutrition and Dietary Supplements 2010, 2:73-83

Published Date: 30 July 2010

Nutritional benefits of flavocoxid in patients with osteoarthritis: efficacy and safety

Robert M Levy, Lakshmi Pillai, Bruce P Burnett

Nutrition and Dietary Supplements 2010, 2:27-38

Published Date: 19 May 2010

Polyphenols as dietary supplements: A double-edged sword

Keith R Martin, Christy L Appel

Nutrition and Dietary Supplements 2010, 2:1-12

Published Date: 16 December 2009