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Effect of Contact Lens Solutions in Stabilizing the Activity of Tear Lysozyme [Letter]
Authors Chaurasiya SK , Khurana A, Soni T
Received 23 January 2024
Accepted for publication 9 February 2024
Published 20 February 2024 Volume 2024:16 Pages 53—54
DOI https://doi.org/10.2147/OPTO.S460908
Checked for plagiarism Yes
Editor who approved publication: Mr Simon Berry
Suraj Kumar Chaurasiya,1,2 Ashi Khurana,3 Tanvi Soni3
1Department of Optometry and Vision Science, CL Gupta Eye Institute, Moradabad, Uttar Pradesh, India; 2Department of Contact Lens and Anterior Segment, CL Gupta Eye Institute, Moradabad, Uttar Pradesh, India; 3Department of Ophthalmology, Anterior Segment and Refractive Services, CL Gupta Eye Institute, Moradabad, Uttar Pradesh, India
Correspondence: Suraj Kumar Chaurasiya, Assistant Professor and Consultant Optometrist, C L Gupta Eye Institute, Ram Ganga Vihar Phase II (Extn), Moradabad, Uttar Pradesh, 244001, India, Tel +91-8809893186, Email [email protected]
View the original paper by Ms Scheuer and colleagues
A Response to Letter has been published for this article.
Dear editor
We are writing to express our thoughts and observations regarding a recently published article “Effect of Contact Lens Solutions in Stabilizing the Activity of Tear Lysozyme” by Scheuer CA et al.1 We would like to congratulate all the authors for their excellent paper. While the study explores the stabilization of lysozyme in daily disposable contact lens package solutions, there are several aspects that need careful consideration and scrutiny.
The study emphasizes the positive outcome for the kalifilcon A contact lens solution, indicating a statistically significant improvement in lysozyme stabilization compared to phosphate buffered saline (PBS) and other daily disposable contact lens solutions and the statistical significance does not necessarily translate to clinical relevance.2,3
The study design raises concerns about its clinical applicability. The in vitro nature of the investigation, using an enzymatic assay based on lysozyme’s activity against Micrococcus luteus, may not fully represent the complex interactions occurring in the human eye during contact lens wear. Real-world conditions involve dynamic factors such as blinking, tear flow, and ocular surface movements that are absent in the in vitro setting.4
Moreover, the study primarily focuses on lysozyme, neglecting the broader spectrum of tear proteins. Tear film comprises various proteins, enzymes, lipids, and metabolites, all contributing to ocular surface homeostasis. Narrowing the investigation to lysozyme alone may oversimplify the intricate dynamics of the tear film and the potential effects of contact lens solutions on overall protein stability.4
Additionally, we would like to understand the author’s views on the potential limitations of the study as highlighting the constraints and uncertainties of the research.
In conclusion, while the study presents intriguing findings on lysozyme stabilization in the kalifilcon A contact lens solution, it is crucial to approach these results with caution. Further research, considering a broader spectrum of tear components in clinically relevants models is warranted to validate the practical significance of these findings.
Funding
There is no funding to report.
Disclosure
The authors report no conflicts of interest in this communication.
References
1. Scheuer CA, Barniak VL, Phatak NR, Rah MJ, Reindel W. Effect of contact lens solutions in stabilizing the activity of tear lysozyme. Clin Optom. 2023;31:119–127. doi:10.2147/OPTO.S404261
2. Morgan PB, Efron N. In vivo dehydration of silicone hydrogel contact lenses. Eye Contact Lens. 2003;29(3):173–176. doi:10.1097/01.ICL.0000072825.23491.59
3. Efron N. Contact Lens Complications E-Book. Elsevier Health Sciences; 2018.
4. Willcox MD. Characterization of the normal microbiota of the ocular surface. Exp Eye Res. 2013;1(117):99–105. doi:10.1016/j.exer.2013.06.003
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