skip to content
Dovepress - Open Access to Scientific and Medical Research
View our mobile site

8847

Cytokines and sympathy: the control of regulatory T cells

Review

(1838) Views  (932) Full article downloads

Authors: Robert E Cone, Sourojit Bhowmick

Published Date April 2010 Volume 2010:2 Pages 41 - 47
DOI: http://dx.doi.org/10.2147/IJICMR.S6758

Robert E Cone, Sourojit Bhowmick

Department of Immunology, Connecticut Lions Vascular Vision Center, University of Connecticut Health Center, Farmington, CT, USA

Abstract: To ensure protection from external invaders, mitigate collateral damage from immune reactions, and prevent immune system responses against self, the immune response is highly regulated by the sympathetic nervous system, cytokines, together with both adaptive and innate regulatory T cells. Moreover, the generation and function of adaptive and innate regulatory T cells is also under strong regulation by the sympathetic nervous system. Here we consider modulation of regulatory T cells by the sympathetic nervous system and cytokines that could lead to strategies for the enhancement of an immune response, or the prevention or mitigation of autoimmune diseases.

Keywords: immunoregulation, regulatory T cells, cytokines, sympathetic nervous system








Readers of this article also read:

Role of aliskiren in cardio-renal protection and use in hypertensives with multiple risk factors
Information technology in pharmacovigilance: Benefits, challenges, and future directions from industry perspectives
Endotoxin-induced IL-6 promoter activation in skeletal muscle requires an NF-κB site
Role of cytokines in the pathogenesis of acute and chronic kidney disease, glomerulonephritis, and end-stage kidney disease
Gestational diabetes: risks, management, and treatment options
Dendritic cells in infectious disease, hypersensitivity, and autoimmunity
Rh isoimmunization in Sub-Saharan Africa indicates need for universal access to anti-RhD immunoglobulin and effective management of D-negative pregnancies
Solid self-nanoemulsifying cyclosporin A pellets prepared by fluid-bed coating: preparation, characterization and in vitro redispersibility
Cumulative clinical experience from over a decade of use of levofloxacin in community-acquired pneumonia: critical appraisal and role in therapy
The role of tumor necrosis factor-receptors in pregnancy with normal and adverse outcome