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Cellular response to low adhesion nanotopographies

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Authors: Matthew J Dalby

Published Date October 2007 Volume 2007:2(3) Pages 373 - 381
DOI: http://dx.doi.org/10.2147/IJN.S

Matthew J Dalby

Centre for Cell Engineering, Division of Infection and Immunity, Institute of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow, UK

Abstract: This review focuses on how cells respond to low-adhesion nanotopographies. In order to do this, fabrication techniques, how cells may locate nanofeatures through the use of filopodia and possible mechanotransductive mechanisms are discussed. From this, examples of low-adhesion topographies and sizes and arrangements that may lead to low-adhesion are discussed. Finally, it is hypothesized as to how specifically low-adhesion materials may fit into the outlined mechanotransductive mechanisms.

Keywords: nanotopography, mechanotransduction, filopodia, nanofabrication








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