Cellular response to low adhesion nanotopographies

Matthew J Dalby

Centre for Cell Engineering, Division of Infection and Immunity, Institute of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow, UK

Abstract: This review focuses on how cells respond to low-adhesion nanotopographies. In order to do this, fabrication techniques, how cells may locate nanofeatures through the use of filopodia and possible mechanotransductive mechanisms are discussed. From this, examples of low-adhesion topographies and sizes and arrangements that may lead to low-adhesion are discussed. Finally, it is hypothesized as to how specifically low-adhesion materials may fit into the outlined mechanotransductive mechanisms.

Keywords: nanotopography, mechanotransduction, filopodia, nanofabrication