Back to Browse Journals » International Journal of Nanomedicine » Volume 2 » Issue 1

Bioconjugated nanoparticle detection of respiratory syncytial virus infection

Authors Ralph A Tripp, Rene Alvarez, Blake Anderson, Les Jones, Craig Weeks, Wei Chen

Published Date May 2007 Volume 2007:2(1) Pages 117—124

DOI http://dx.doi.org/

Published 22 May 2007

Ralph A Tripp1, Rene Alvarez1, Blake Anderson1, Les Jones1, Craig Weeks1, Wei Chen2

1College of Veterinary Medicine, Department of Infectious Diseases, Center for Disease Intervention, University of Georgia, Athens, GA, USA; 2Department of Physics, University of Texas at Arlington, Arlington, TX, USA

Abstract: The integration of nanotechnology with biology has produced major advances in molecular diagnostics, therapeutics, and bioengineering. Recent advances have led to the development of functionalized nanoparticles (NPs) that are covalently linked to biological molecules such as antibodies, peptides, proteins, and nucleic acids. These functionalized NPs allow for development of novel diagnostic tools and methods, particularly for pathogens, as rapid and sensitive diagnostics are essential for defining the emergence of infection, determining the period that preventive measures should be applied, for evaluating drug and vaccine efficacy, and for controlling epidemics. In this study, we show that functionalized NPs conjugated to monoclonal antibodies can be used to rapidly and specifically detect respiratory syncytial virus in vitro and in vivo. These results suggest that functionalized NPs can provide direct, rapid, and sensitive detection of viruses and thereby bridge the gap between current cumbersome virus detection assays and the burgeoning need for more rapid and sensitive detection of viral agents.

Keywords: RSV, virus, nanoparticle, bioconjugated, functionalized

Download Article [PDF] 

Readers of this article also read:

Vincristine sulfate liposomal injection for acute lymphoblastic leukemia

Soosay Raj TA, Smith AM, Moore AS

International Journal of Nanomedicine 2013, 8:4361-4369

Published Date: 6 November 2013

Fibrin glue for Gundersen flap surgery

Chung HW, Mehta JS

Clinical Ophthalmology 2013, 7:479-484

Published Date: 6 March 2013

Bimatoprost ophthalmic solution 0.03% lowered intraocular pressure of normal-tension glaucoma with minimal adverse events. [Corrigendum]

Tsumura T, Yoshikawa K, Suzumura H, Kimura T, Sasaki S, Kimura I, Takeda R

Clinical Ophthalmology 2013, 7:129-130

Published Date: 16 January 2013

Topical azithromycin or ofloxacin for endophthalmitis

Stewart MW, Stewart ML

Clinical Ophthalmology 2013, 7:35-38

Published Date: 31 December 2012

Corrigendum

Sakai T, Kohzaki K, Watanabe A, Tsuneoka H, Shimadzu M

Clinical Ophthalmology 2012, 6:1035-1036

Published Date: 5 July 2012

Corrigendum

Chen ZQ, Liu Y, Zhao JH, Wang L, Feng NP

International Journal of Nanomedicine 2012, 7:1709-1710

Published Date: 30 March 2012

Dapoxetine: an evidence-based review of its effectiveness in treatment of premature ejaculation

McCarty EJ, Dinsmore WW

Core Evidence 2012, 7:1-14

Published Date: 19 January 2012

Oral fondaparinux: use of lipid nanocapsules as nanocarriers and in vivo pharmacokinetic study

Ramadan A, Lagarce F, Tessier-Marteau A, Thomas O, Legras P, Macchi L, Saulnier P, Benoit JP

International Journal of Nanomedicine 2011, 6:2941-2951

Published Date: 21 November 2011

Difluprednate ophthalmic emulsion 0.05% (Durezol®) administered two times daily for managing ocular inflammation and pain following cataract surgery

Stephen Smith, Douglas Lorenz, James Peace, et al.

Clinical Ophthalmology 2010, 4:983-991

Published Date: 30 August 2010

Comparing techniques for pterygium surgery

Atilla Alpay, Suat Hayri Ugurbas, Berktug Erdogan

Clinical Ophthalmology 2009, 3:69-74

Published Date: 17 September 2008