Back to Browse Journals » International Journal of Nanomedicine » Volume 1 » Issue 1

Selective adhesion and mineral deposition by osteoblasts on carbon nanofiber patterns

Authors Dongwoo Khang, Michiko Sato, Rachel L Price, Alexander E Ribbe Thomas J Webster

Published Date January 2006 Volume 2006:1(1) Pages 65—72

DOI http://dx.doi.org/

Published 25 January 2006

Dongwoo Khang1, Michiko Sato4, Rachel L Price2, Alexander E Ribbe3
Thomas J Webster2,4

1Department of Physics, 2Weldon School of Biomedical Engineering, 3Purdue Laboratory of Chemical Nanotechnology and Departments of Chemistry, and 4School of Materials Engineering, Purdue

Abstract: In an effort to develop better orthopedic implants, osteoblast (bone-forming cells) adhesion was determined on microscale patterns (30 μm lines) of carbon nanofibers placed on polymer substrates. Patterns of carbon nanofibers (CNFs) on a model polymer (polycarbonate urethane [PCU]) were developed using an imprinting method that placed CNFs in selected regions. Results showed the selective adhesion and alignment of osteoblasts on CNF patterns placed on PCU. Results also showed greater attraction forces between fibronectin and CNF (compared with PCU) patterns using atomic force microscope force-displacement curves. Because fibronectin is a protein that mediates osteoblast adhesion, these results provide a mechanism of why osteoblast adhesion was directed towards CNF patterns. Lastly, this study showed that the directed osteoblast adhesion on CNF patterns translated to enhanced calcium phosphate mineral deposition along linear patterns of CNFs on PCU. Since CNFs are conductive materials, this study formulated substrates that through electrical stimulation could be used in future investigations to further promote osteoblasts to deposit anisotropic patterns of calcium containing mineral similar to that observed in long bones.

Keywords: carbon nanotubes, carbon nanofibers, osteoblasts, orthopedic, biomaterials, alignment

Download Article [PDF] 

Readers of this article also read:

Effect of low-addition soft contact lenses with decentered optical design on myopia progression in children: a pilot study

Fujikado T, Ninomiya S, Kobayashi T, Suzaki A, Nakada M, Nishida K

Clinical Ophthalmology 2014, 8:1947-1956

Published Date: 23 September 2014

Baseline characteristics of depressive disorders in Thai outpatients: findings from the Thai Study of Affective Disorders

Wongpakaran T, Wongpakaran N, Pinyopornpanish M, Srisutasanavong U, Lueboonthavatchai P, Nivataphand R, Apisiridej N, Petchsuwan D, Saisavoey N, Wannarit K, Ruktrakul R, Srichan T, Satthapisit S, Nakawiro D, Hiranyatheb T, Temboonkiat A, Tubtimtong N, Rakkhajeekul S, Wongtanoi B, Tanchakvaranont S, Bookkamana P

Neuropsychiatric Disease and Treatment 2014, 10:217-223

Published Date: 31 January 2014

Interaction between nanoparticles generated by zinc chloride treatment and oxidative responses in rat liver

Azzouz I, Trabelsi H, Hanini A, Ferchichi S, Tebourbi O, Sakly M, Abdelmelek H

International Journal of Nanomedicine 2014, 9:223-229

Published Date: 27 December 2013

Assessment of vitreous drug concentration in the porcine eye following intracameral injection or irrigation with moxifloxacin

Matsuura K, Inoue Y, Sasaki S, Hata Y, Ohmura N, Gotou T

Clinical Ophthalmology 2013, 7:1397-1402

Published Date: 9 July 2013

In vitro evaluation of the effects of graphene platelets on glioblastoma multiforme cells

Jaworski S, Sawosz E, Grodzik M, Winnicka A, Prasek M, Wierzbicki M, Chwalibog A

International Journal of Nanomedicine 2013, 8:413-420

Published Date: 24 January 2013

A new approach to the treatment of recurrent aphthous stomatitis with bioadhesive gels containing cyclosporine A solid lipid nanoparticles: in vivo/in vitro examinations

Karavana SY, Gökçe EH, Rençber S, Özbal S, Pekçetin Ç, Güneri P, Ertan G

International Journal of Nanomedicine 2012, 7:5693-5704

Published Date: 9 November 2012

Self-assembled supramolecular nano vesicles for safe and highly efficient gene delivery to solid tumors

Li W, Li H, Li J, Wang H, Zhao H, Zhang L, Xia Y, Ye Z, Gao J, Dai J, Wang H, Guo Y

International Journal of Nanomedicine 2012, 7:4661-4677

Published Date: 22 August 2012

Fabrication and characterization of a rapid prototyped tissue engineering scaffold with embedded multicomponent matrix for controlled drug release

Chen M, Le DQ, Hein S, Li P, Nygaard JV, Kassem M, Kjems J, Besenbacher F, Bünger C

International Journal of Nanomedicine 2012, 7:4285-4297

Published Date: 3 August 2012