Back to Browse Journals » International Journal of Nanomedicine » Volume 1 » Issue 1

Selective adhesion and mineral deposition by osteoblasts on carbon nanofiber patterns

Authors Dongwoo Khang, Michiko Sato, Rachel L Price, Alexander E Ribbe Thomas J Webster

Published Date January 2006 Volume 2006:1(1) Pages 65—72

DOI

Published 25 January 2006

Dongwoo Khang1, Michiko Sato4, Rachel L Price2, Alexander E Ribbe3
Thomas J Webster2,4

1Department of Physics, 2Weldon School of Biomedical Engineering, 3Purdue Laboratory of Chemical Nanotechnology and Departments of Chemistry, and 4School of Materials Engineering, Purdue

Abstract: In an effort to develop better orthopedic implants, osteoblast (bone-forming cells) adhesion was determined on microscale patterns (30 μm lines) of carbon nanofibers placed on polymer substrates. Patterns of carbon nanofibers (CNFs) on a model polymer (polycarbonate urethane [PCU]) were developed using an imprinting method that placed CNFs in selected regions. Results showed the selective adhesion and alignment of osteoblasts on CNF patterns placed on PCU. Results also showed greater attraction forces between fibronectin and CNF (compared with PCU) patterns using atomic force microscope force-displacement curves. Because fibronectin is a protein that mediates osteoblast adhesion, these results provide a mechanism of why osteoblast adhesion was directed towards CNF patterns. Lastly, this study showed that the directed osteoblast adhesion on CNF patterns translated to enhanced calcium phosphate mineral deposition along linear patterns of CNFs on PCU. Since CNFs are conductive materials, this study formulated substrates that through electrical stimulation could be used in future investigations to further promote osteoblasts to deposit anisotropic patterns of calcium containing mineral similar to that observed in long bones.

Keywords: carbon nanotubes, carbon nanofibers, osteoblasts, orthopedic, biomaterials, alignment

Download Article [PDF] 

Readers of this article also read:

Vincristine sulfate liposomal injection for acute lymphoblastic leukemia [Corrigendum]

Soosay Raj TA, Smith AM, Moore AS

International Journal of Nanomedicine 2013, 8:4705-4706

Published Date: 5 December 2013

Targeting nanomaterials: future drugs for cancer chemotherapy

Zhang Y, Chen T

International Journal of Nanomedicine 2012, 7:5283-5286

Published Date: 10 October 2012

Development of a nanoporous and multilayer drug-delivery platform for medical implants

Karagkiozaki V, Vavoulidis E, Karagiannidis PG, Gioti M, Fatouros DG, Vizirianakis IS, Logothetidis S

International Journal of Nanomedicine 2012, 7:5327-5338

Published Date: 8 October 2012

Corrigendum

Wu Q, Chu M

International Journal of Nanomedicine 2012, 7:4531-4532

Published Date: 15 August 2012

Blood–brain barrier: a real obstacle for therapeutics

Shiekh FA

International Journal of Nanomedicine 2012, 7:4065-4067

Published Date: 27 July 2012

Corrigendum

Jalil MA, Moongfangklang M, Innate K, Mitatha S, Ali J, Yupapin PP

International Journal of Nanomedicine 2012, 7:3279-3280

Published Date: 29 June 2012

Corrigendum

Chen ZQ, Liu Y, Zhao JH, Wang L, Feng NP

International Journal of Nanomedicine 2012, 7:1709-1710

Published Date: 30 March 2012