Back to Browse Journals » Cancer Management and Research » Volume 2

Treatment of cutaneous melanoma: current approaches and future prospects

Authors Alain P Algazi, Christopher W Soon, Adil I Daud

Published Date August 2010 Volume 2010:2 Pages 197—211

DOI http://dx.doi.org/10.2147/CMAR.S6073

Published 17 August 2010

Alain P Algazi1, Christopher W Soon2, Adil I Daud1

1Department of Medicine, Division of Hematology and Oncology, 2Department of Dermatology, University of California, San Francisco San Francisco, CA, USA

Abstract: Melanoma is the most aggressive and deadly type of skin cancer. Surgical resection with or without lymph node sampling is the standard of care for primary cutaneous melanoma. Adjuvant therapy decisions may be informed by careful consideration of prognostic factors. High-dose adjuvant interferon alpha-2b increases disease-free survival and may modestly improve overall survival. Less toxic alternatives for adjuvant therapy are currently under study. External beam radiation therapy is an option for nodal beds where the risk of local recurrence is very high. In-transit melanoma metastases may be treated locally with surgery, immunotherapy, radiation, or heated limb perfusion. For metastatic melanoma, the options include chemotherapy or immunotherapy; targeted anti-BRAF and anti-KIT therapy is under active investigation. Standard chemotherapy yields objective tumor responses in approximately 10%–20% of patients, and sustained remissions are uncommon. Immunotherapy with high-dose interleukin-2 yields objective tumor responses in a minority of patients; however, some of these responses may be durable. Identification of activating mutations of BRAF, NRAS, c-KIT, and GNAQ in distinct clinical subtypes of melanoma suggest that these are molecularly distinct. Emerging data from clinical trials suggest that substantial improvements in the standard of care for melanoma may be possible.

Keywords: melanoma, resection, immune modulation, small molecule kinase inhibitors, chemotherapy, clinical trials

Download Article [PDF] 

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php

Readers of this article also read:

Fever without source in infants and young children: dilemma in diagnosis and management

Elhassanien AF, Alghaiaty HA, Alrefaee F

Risk Management and Healthcare Policy 2013, 6:7-12

Published Date: 29 April 2013

Managing myelodysplastic syndromes in very old patients: a teaching case report

Niscola P, Palombi M, Trawinska MM, Tendas A, Giovannini M, Scaramucci L, Perrotti A, de Fabritiis P

Clinical Interventions in Aging 2013, 8:391-394

Published Date: 11 April 2013

Fungus-mediated biological synthesis of gold nanoparticles: potential in detection of liver cancer

Chauhan A, Zubair S, Tufail S, Sherwani A, Sajid M, Raman SC, Azam A, Owais M

International Journal of Nanomedicine 2011, 6:2305-2319

Published Date: 12 October 2011

Diffuse infiltrating retinoblastoma invading subarachnoid space

Kase S, Yoshida K, Suzuki S, Ohshima K, Ohno S, Ishida S

Clinical Ophthalmology 2011, 5:861-863

Published Date: 23 June 2011

DataGenno: building a new tool to bridge molecular and clinical genetics

Fabricio F Costa, Luciano S Foly, Marcelo P Coutinho

The Application of Clinical Genetics 2011, 4:45-54

Published Date: 18 March 2011

Nanoparticles as biochemical sensors

Afaf El-Ansary, Layla M Faddah

Nanotechnology, Science and Applications 2010, 3:65-76

Published Date: 23 September 2010

High-efficient dye-sensitized solar cell based on novel TiO2 nanorod/nanoparticle bilayer electrode

Hoda Hafez, Zhang Lan, Qinghua Li, et al

Nanotechnology, Science and Applications 2010, 3:45-51

Published Date: 26 August 2010

Health literacy and health seeking behavior among older men in a middle-income nation

Paul A Bourne, Chloe Morris, Christopher AD Charles, et al

Patient Related Outcome Measures 2010, 1:39-49

Published Date: 26 May 2010

Prolonged rupture of membranes in term infants: should all babies be screened?

Christopher Flannigan, Martina Hogan

Clinical Audit 2010, 2:1-6

Published Date: 9 February 2010

Effects of selective serotonin reuptake inhibitors on motor neuron survival

Lily B Anderson, Phaedra B Anderson, Thea B Anderson, Amy Bishop, et al.

International Journal of General Medicine 2009, 2:109-115

Published Date: 28 May 2009