Ligneous conjunctivitis in a patient with Crohn′s disease
Graciana Fuentes-Páez1, José M Herreras1, M del C Méndez2, MA Saorni1,2
1Ocular Immunology and Uveitis Unit, Institute of Ophthalmobiology (IOBA), University of Valladolid, Valladolid, Spain and Hospital Universitario de Valladolid, Spain; 2Ocular Pathology and Lab Registry “Miguel N. Burnier”, Institute of Ophthalmobiology (IOBA), University of Valladolid, Valladolid, Spain
Objective: Report the case of a patient with Crohn´s disease and ligneous conjunctivitis.
Methods: Interventional case report of a 27-year old female patient, with a 4-year history of Crohn´s disease, was seen for right eye conjunctival ulcer after resolved chemical trauma. Conjunctival biopsy was performed for histopathology, immunofluorescence microscopy, and immunohistochemistry testing.
Results: Microbiology tests were negative for bacteria and fungi. PCR was negative for atypical mycobacteria and Herpes. Ocular Crohn´s disease, Whipple disease, and amyloidosis were ruled out. Immunofluorescence microscopy revealed characteristic IgG κ and λ light chain deposits, and fibrin deposition was confirmed through Lendrum´s Martius, Scarlet, and Blue technique. Endogenous plasminogen levels were normal. Recurrent ulcers did not resolve after treatment with infliximab, but only after four surgeries, topical steroids, 1% cyclosporine, heparin (5000 units/ml), and hyaluronidase (1.5 mg/ml). After 9 months of follow-up, nasal symblepharon was observed as sequela.
Conclusions: We report the case of a patient with unilateral ligneous conjunctivitis, triggered by chemical injury, and Crohn´s disease.
Keywords: Crohn´s disease, immunofluorescence microscopy, ligneous conjunctivitis, plasminogen, ulcerative conjunctivitis
This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php
Readers of this article also read:
Xie TS, Wu NP
Published Date: 19 November 2013
Hudoklin S, Zupančič D, Makovec D, Kreft ME, Romih R
Published Date: 14 October 2013
England CG, Priest T, Zhang G, Sun X, Patel DN, McNally LR, van Berkel V, Gobin AM, Frieboes HB
Published Date: 1 October 2013
Multinucleation and cell dysfunction induced by amorphous silica nanoparticles in an L-02 human hepatic cell line
Wang W, Li Y, Liu X, Jin M, Du H, Liu Y, Huang P, Zhou X, Yuan L, Sun Z
Published Date: 19 September 2013
Bitzer J, von Stenglin A, Bannemerschult R
Published Date: 26 April 2013
Tsasis P, Evans JM, Forrest D, Jones RK
Published Date: 14 March 2013
Mansour AM, Shahin M, Kofoed PK, Parodi MB, Shami M, Schwartz SG
Published Date: 6 March 2012
Iancu C, Mocan L
Published Date: 21 October 2011
Effects of a moderate low-carbohydrate diet on preferential abdominal fat loss and cardiovascular risk factors in patients with type 2 diabetes
Sasakabe T, Haimoto H, Umegaki H, Wakai K
Published Date: 29 April 2011
L Au, K Guduru, G Lipscomb, SP Kelly
Published Date: 11 January 2007