Back to Browse Journals » Vascular Health and Risk Management » Volume 4 » Issue 3

Antiplatelet drugs in cardiological practice: Established strategies and new developments

Authors Florian Krötz, Hae-Young Sohn, Volker Klauss

Published Date June 2008 Volume 2008:4(3) Pages 637—645

DOI http://dx.doi.org/10.2147/VHRM.S2691

Published 30 June 2008

Florian Krötz, Hae-Young Sohn, Volker Klauss

Cardiology, Medical Policlinic, Ludwig-Maximilians-Universität, Ziemssenstr. 1, 80336 München

Abstract: A common pathophysiological course in vascular diseases is an overwhelming activation and aggregation of blood platelets, which results in atherothrombosis. By causing the last decisive step of cerebral, coronary, or peripheral arterial ischemia thrombotic complications of atherosclerotic disease represent a major player in death cause statistics of most western countries. The development of novel therapies against platelet-dependent thrombosis and the concurrent improvement of existing therapeutic strategies thus is a paramount focus of pharmaceutical research. Currently, efficiency, dosing and indications of established antiplatelet substances are being re-evaluated, whilst new, so far unrecognized molecular targets for inhibition of platelet activity come up front. This not only allows for interesting new therapeutical options, but also widens our insight into the role platelets play in atherosclerosis in general. This article summarizes the relevant pathophysiology of platelet activation, presents current concepts in antiplatelet drug therapy, and highlights the role of platelets in vascular diseases apart from atherothrombosis.

Keywords: atherothrombosis, antiplatelet drug therapy, pathophysiology, platelet activation

Download Article [PDF] 

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php

Readers of this article also read:

A novel chemosynthetic peptide with ß-sheet motif efficiently kills Klebsiella pneumoniae in a mouse model

Tan S, Gan C, Li R, Ye Y, Zhang S, Wu X, Yang YY, Fan W, Wu M

International Journal of Nanomedicine 2015, 10:1045-1059

Published Date: 9 February 2015

Disruption of human papillomavirus 16 E6 gene by clustered regularly interspaced short palindromic repeat/Cas system in human cervical cancer cells [Corrigendum]

Yu L, Wang XL, Zhu D, Ding WC, Wang LM, Zhang CL, Jiang XH, Shen H, Liao SJ, Ma D, Hu Z, Wang H

OncoTargets and Therapy 2015, 8:365-366

Published Date: 4 February 2015

Association between vitamin D insufficiency and adverse pregnancy outcome: global comparisons

Bener A, Al-Hamaq AO, Saleh NM

International Journal of Women's Health 2013, 5:523-531

Published Date: 4 September 2013

Aggressive behavior, cognitive impairment, and depressive symptoms in elderly subjects

Margari F, Sicolo M, Spinelli L, Mastroianni F, Pastore A, Craig F, Petruzzelli MG

Neuropsychiatric Disease and Treatment 2012, 8:347-353

Published Date: 1 August 2012

Managing hypercholesterolemia and its correlation with carotid plaque morphology in patients undergoing carotid endarterectomy

Kittipan Rerkasem, Patrick J Gallagher, Robert F Grimble, Philip C Calder, Clifford P Shearman

Vascular Health and Risk Management 2008, 4:1259-1264

Published Date: 12 September 2008

The influence of polymorbidity, revascularization, and wound therapy on the healing of arterial ulceration

Joerg Tautenhahn, Ralf Lobmann, Brigitte Koenig, Zuhir Halloul, Hans Lippert, Thomas Buerger

Vascular Health and Risk Management 2008, 4:683-689

Published Date: 30 June 2008

Are pleiotropic effects of statins real?

Alberto Corsini, Nicola Ferri, Michele Cortellaro

Vascular Health and Risk Management 2007, 3:611-613

Published Date: 20 November 2007

Erratum

Vascular Health and Risk Management 2006, 2:515-515

Published Date: 13 May 2006

ISVH – October Newsletter

Prof. Roland Asmar, David Oldfield

Vascular Health and Risk Management 2008, 4:1145-1146

Published Date: 30 November 1999