Back to Browse Journals » Vascular Health and Risk Management » Volume 4 » Issue 2

Vascular risk factors, cognitve decline, and dementia

Authors E Duron, Olivier Hanon

Published Date May 2008 Volume 2008:4(2) Pages 363—381

DOI http://dx.doi.org/10.2147/VHRM.S1839

Published 6 May 2008

E Duron, Olivier Hanon

Broca Hospital, Paris, France

Abstract: Dementia is one of the most important neurological disorders in the elderly. Aging is associated with a large increase in the prevalence and incidence of degenerative (Alzheimer’s disease) and vascular dementia, leading to a devastating loss of autonomy. In view of the increasing longevity of populations worldwide, prevention of dementia has turned into a major public health challenge. In the past decade, several vascular risk factors have been found to be associated with vascular dementia but also Alzheimer’s disease. Some longitudinal studies, have found significant associations between hypertension, diabetus mellitus, and metabolic syndrome, assessed at middle age, and dementia. Studies assessing the link between hypercholesterolemia, atrial fibrillation, smoking, and dementia have given more conflicting results. Furthermore, some studies have highlighted the possible protective effect of antihypertensive therapy on cognition and some trials are evaluating the effects of statins and treatments for insulin resistance. Vascular risk factors and their treatments are a promising avenue of research for prevention of dementia, and further long-term, placebo-controlled, randomized studies, need to be performed.

Keywords: dementia, hypertension, diabetus mellitus, hypercholesterolemia, metabolic syndrome

Download Article [PDF] 

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php

Readers of this article also read:

Disruption of human papillomavirus 16 E6 gene by clustered regularly interspaced short palindromic repeat/Cas system in human cervical cancer cells [Corrigendum]

Yu L, Wang XL, Zhu D, Ding WC, Wang LM, Zhang CL, Jiang XH, Shen H, Liao SJ, Ma D, Hu Z, Wang H

OncoTargets and Therapy 2015, 8:365-366

Published Date: 4 February 2015

An anthropometric study to evaluate the correlation between the occlusal vertical dimension and length of the thumb

Basnet BB, Parajuli PK, Singh RK, Suwal P, Shrestha P, Baral D

Clinical, Cosmetic and Investigational Dentistry 2015, 7:33-39

Published Date: 3 February 2015

Maternal and neonatal tetanus elimination: from protecting women and newborns to protecting all

Khan R, Vandelaer J, Yakubu A, Raza AA, Zulu F

International Journal of Women's Health 2015, 7:171-180

Published Date: 3 February 2015

On the antiatherogenic effects of vitamin E: the search for the Holy Grail

Francesco Galli, Dimitrios Kirmizis, Dimitrios Chatzidimitriou

Vascular Health and Risk Management 2010, 6:69-71

Published Date: 16 February 2010

Role of aliskiren in cardio-renal protection and use in hypertensives with multiple risk factors

Eduardo Pimenta, Suzanne Oparil

Vascular Health and Risk Management 2009, 5:453-463

Published Date: 19 May 2009

A review of pioglitazone HCL and glimepiride in the treatment of type 2 diabetes

Mozhgan Dorkhan, Anders Frid

Vascular Health and Risk Management 2007, 3:721-731

Published Date: 20 November 2007

Severe supraaortal atherosclerotic disease resembling Takayasu’s Arteritis

Bernhard Kis, Thomas Liebig, Peter Berlit

Vascular Health and Risk Management 2007, 3:351-354

Published Date: 15 August 2007