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Review

Noteworthy comment: Aging is associated with important changes in both the distribution and the composition of adipose tissue. Fat is redistributed from the subcutaneous to the visceral depot and increased inflammation participates in adipocyte dysfunction. This redistribution of adipose tissue favoring visceral fat deposition influences negatively both longevity and healthy aging as shown in numerous animal models. These modifications observed during aging are associated with leptin resistance which blunts its normal central and peripheral functions leading to a decrease in neuroendocrine function and insulin sensitivity, an imbalance in energy regulation, and disturbances in lipid metabolism. Thus, the current review is valuable in providing information about how age-related leptin resistance triggers metabolic disturbances and affects the longevity.

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Role of leptin resistance in the development of obesity in older patients

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