Back to Journals » International Journal of General Medicine » Volume 2
Anti-inflammatory effects of hyaluronan in arthritis therapy: Not just for viscosity
Authors Masuko K , Murata M, Yudoh K, Kato T, Nakamura H
Published 30 April 2009 Volume 2009:2 Pages 77—81
DOI https://doi.org/10.2147/IJGM.S5495
Review by Single anonymous peer review
Peer reviewer comments 2
Kayo Masuko1, Minako Murata2, Kazuo Yudoh2, Tomohiro Kato1, Hiroshi Nakamura3
1Department of Biochemistry; 2Institute of Medical Science, St. Marianna University School of Medicine, Kawasaki-shi, Kanagawa, Japan; 3Department of Joint Disease and Rheumatism, Nippon Medical School, Bunkyo-ku, Tokyo, Japan
Abstract: Hyaluronic acid (HA) has been widely used for viscosupplementation of diseased or aged articular joints. However, recent investigations have revealed the active anti-inflammatory or chondroprotective effect of HA, suggesting its potential role in attenuation of joint damage. In particular, interactions between HA and other inflammatory mediators are attracting interest. This review summarizes several aspects of recent investigations of the anti-inflammatory effects of HA in arthritis.
Keywords: hyaluronan, inflammation, chondroprotection
© 2009 The Author(s). This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.