skip to content
Dovepress - Open Access to Scientific and Medical Research
View our mobile site

8838

An overview of urinary proteomics applications in human diseases

Review

(1157) Views  (541) Full article downloads

Authors: Gayathri Gopalan, Veena S Rao, Vijay V Kakkar

Published Date November 2010 Volume 2010:1 Pages 183 - 192
DOI: http://dx.doi.org/10.2147/IJHTS.S13129

Gayathri Gopalan1, Veena S Rao1, Vijay V Kakkar2
1Tata Proteomics and Coagulation Unit, Thrombosis Research Institute, Bangalore, India; 2Thrombosis Research Institute, London, United Kingdom

Abstract: A major challenge in clinical proteomics is the identification of reliable biomarkers that help early diagnosis of disease, which will not only assist the clinician but also contribute to the development of personalized medicine. Urinary proteomic studies provide information on urine composition along with insight into renal physiology, kidney disease states, and other associated diseases. In the past decade, technical advances in the design of highly sensitive mass spectrometers and accurate protein quantitation technologies have led to the application of urinary proteomics in diverse research areas, including basic biomedical and clinical sciences. Of specific interest is the identification of biomarkers by virtue of improvements in instrumentation, bioinformatics, and database development. Here, we review recent discoveries in urinary proteomics with respect to identifying novel biomarker, its current challenges, and potential for future research.

Keywords: urinary proteomics, biomarker, mass spectrometry




 

Other articles by Dr Veena Rao



Readers of this article also read:

Role of aliskiren in cardio-renal protection and use in hypertensives with multiple risk factors
Overview of the pathogenesis and treatment of chronic inflammatory demyelinating polyneuropathy with intravenous immunoglobulins
Endothelial vascular smooth muscle cell coculture assay for high throughput screening assays to identify antiangiogenic and other therapeutic molecules
Gaucher disease: clinical profile and therapeutic developments
The relationship between deliberate self-harm behavior, body dissatisfaction, and suicide in adolescents: current concepts
Zinc oxide nanoparticles as selective killers of proliferating cells
Drug discovery in Parkinson's disease: update and developments in the use of cellular models
Cumulative clinical experience from over a decade of use of levofloxacin in community-acquired pneumonia: critical appraisal and role in therapy
Stem cell-mediated osteogenesis: therapeutic potential for bone tissue engineering
Natural killer cells: role in local tumor growth and metastasis
  • Testimonials

    "You do a tremendous job!!" Ruben Restrepo, The University of Texas Health Science Center at San Antonio