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International Journal of Nanomedicine
ISSN: 1178-2013
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Journal Articles:
- Nanoparticle Applications in Brain Disorders: Gene Therapy and Enzyme Replacement Therapy (4)
- Surfactants in Nanomedicine: Enhancing Efficacy and Potential Applications (1)
- Plant-based Nanoparticles for Advanced Medical Applications: Current Trends and Future Prospects (11)
- Nanomedicine for Cancer Immunotherapy (5)
- Design, Development, and Translational Science of Inhaled Nanomedicines for Pulmonary, Nasal, and Nose-to-Brain Delivery (2)
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Nanoparticle Applications in Brain Disorders: Gene Therapy and Enzyme Replacement Therapy
Brain disorders are one of the most challenging targets for novel therapies due to their location and the presence of numerous barriers that limit the efficacy of treatments. Nanotechnologies, such as nanoparticles and nanomedicines, are promising tools to overcome the limitations of traditional treatments thanks to their ability to protect sensitive molecules from degradation and reduce off-target drug toxicity in vivo by using targeting ligands to cross the blood brain barrier, selectively accumulate at the target site, and release their payload in the brain parenchyma. In fact, the use of complex molecules such as DNA, RNA, siRNA, mRNA, enzymes, or proteins has shown promising results in hard-to-treat pathologies such as neurodegenerative disorders and brain cancer. This Article Collection collects the most recent innovations in the field of nanoparticle-based gene and enzyme replacement therapy for brain diseases.
How Precise are Nanomedicines in Overcoming the Blood–Brain Barrier? A Comprehensive Review of the Literature
Mohapatra P, Gopikrishnan M, Doss C GP, Chandrasekaran N
International Journal of Nanomedicine 2024, 19:2441-2467
Published Date: 8 March 2024
Strategies for Improved pDNA Loading and Protection Using Cationic and Neutral LNPs with Industrial Scalability Potential Using Microfluidic Technology
Ottonelli I, Adani E, Bighinati A, Cuoghi S, Tosi G, Vandelli MA, Ruozi B, Marigo V, Duskey JT
International Journal of Nanomedicine 2024, 19:4235-4251
Published Date: 14 May 2024
Brain Targeting Nanomedicines: Pitfalls and Promise
Kakinen A, Jiang Y, Davis TP, Teesalu T, Saarma M
International Journal of Nanomedicine 2024, 19:4857-4875
Published Date: 27 May 2024
Engineered Exosomes Containing microRNA-29b-2 and Targeting the Somatostatin Receptor Reduce Presenilin 1 Expression and Decrease the β-Amyloid Accumulation in the Brains of Mice with Alzheimer’s Disease
Lin EY, Hsu SX, Wu BH, Deng YC, Wuli W, Li YS, Lee JH, Lin SZ, Harn HJ, Chiou TW
International Journal of Nanomedicine 2024, 19:4977-4994
Published Date: 29 May 2024